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872 results
  • Enhancing Hepatitis C Virus pseudoparticles infectivity through p7NS2 cellular expression. [Journal Article]
    J Virol Methods 2019; :113714Soares HR, Ferreira-Fernandes M, … Coroadinha AS
  • Hepatitis C pseudoparticles (HCVpp) are used to evaluate HCV cell entry while screening for neutralizing antibodies induced upon vaccination or while screening for new antiviral drugs. In this work we explore the stable production of HCVpp aiming to reduce the variability associated with transient productions. The performance of stably produced HCVpp was assessed by evaluating the influence of Hu…
  • Optical Resolution of Rimantadine. [Journal Article]
    Molecules 2019; 24(9)Han J, Takeda R, … Soloshonok VA
  • This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medic…
  • Computational Study of HCV p7 Channel: Insight into a New Strategy for HCV Inhibitor Design. [Journal Article]
    Interdiscip Sci 2019; 11(2):292-299Ying B, Pang S, … Wang J
  • HCV p7 protein is a cation-selective ion channel, playing an essential role during the life cycle of HCV viruses. To understand the cation-selective mechanism, we constructed a hexameric model in lipid bilayers of HCV p7 protein for HCB JFH-1 strain, genotype 2a. In this structural model, His9 and Val6 were key factors for the HCV cation-selective ion channel. The histidine residues at position 9…
  • Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. [Journal Article]
    J Am Chem Soc 2018; 140(45):15219-15226Thomaston JL, Polizzi NF, … DeGrado WF
  • Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar functionality, a small-molecule approach is often viewed as insufficient to achieve high affinity and specificity. Here we show that small molecules can enable potent inhibition by targeting key waters. The M2 proton channel of influenza A is the target of the antiviral drugs amantadine and rimantadine.…
  • Alkyl-imino sugars inhibit the pro-oncogenic ion channel function of human papillomavirus (HPV) E5. [Journal Article]
    Antiviral Res 2018; 158:113-121Wetherill LF, Wasson CW, … Macdonald A
  • Despite the availability of prophylactic vaccines the burden of human papillomavirus (HPV) associated malignancy remains high and there is a need to develop additional therapeutic strategies to complement vaccination. We have previously shown that the poorly characterised E5 oncoprotein forms a virus-coded ion channel or viroporin that was sensitive to the amantadine derivative rimantadine. We no…
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