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324,350 results
  • UDP-glycosyltransferases contribute to spirotetramat resistance in Aphis gossypii Glover. [Review]
    Pestic Biochem Physiol. 2020 Jun; 166:104565.Pan Y, Wen S, … Shang Q
  • Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze the conjugation of small lipophilic endogenous and exogenous compounds with sugars to produce water-soluble glycosides, playing an important role in insect endobiotic regulation and xenobiotic detoxification. In this study, two UGT-inhibitors, sulfinpyrazone and 5-nitrouracil, significantly increased spirotetramat toxicity against thi…
  • The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin. [Journal Article]
    Sci Rep. 2020 May 22; 10(1):8536.Kopel J, Higuchi K, … Ganapathy V
  • Metformin is the first-line treatment for type 2 diabetes. Inhibition of hepatic gluconeogenesis is the primary contributor to its anti-diabetic effect. Metformin inhibits complex I and α-glycerophosphate shuttle, and the resultant increase in cytoplasmic NADH/NAD+ ratio diverts glucose precursors away from gluconeogenesis. These actions depend on metformin-mediated activation of AMP kinase (AMPK…
  • Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis. [Journal Article]
    Kidney Int. 2020 Feb 17 [Online ahead of print]Scindia Y, Wlazlo E, … Swaminathan S
  • Lupus nephritis is the end organ manifestation of systemic lupus erythematosus. Iron metabolism and its master regulator, hepcidin, are known to regulate cell proliferation and inflammation, but their direct role in the pathophysiology of lupus nephritis remains under-investigated. Exogenous hepcidin reduced the severity of lupus nephritis in MRL/lpr mice, a preclinical model of spontaneous syste…
  • Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex. [Journal Article]
    J Biol Chem. 2020 May 21 [Online ahead of print]Doigneaux C, Pedley AM, … Tavassoli A
  • The purinosome is a dynamic metabolic complex composed of enzymes responsible for de novo purine biosynthesis, whose formation has been associated with elevated purine demand. However, the physiological conditions that govern purinosome formation in cells remain unknown. Here, we report that purinosome formation is up-regulated in cells in response to a low-oxygen microenvironment (hypoxia). We d…
  • Sofosbuvir as a potential option for the treatment of COVID-19. [Letter]
    Acta Biomed. 2020 May 11; 91(2):236-238.Nourian A, Khalili H
  • Sofosbuvir may be a potential option in the treatment of COVID-19 based on the similarity between the replication mechanisms of the HCV and the coronavirus. According the limited experimental evidences, it is hypothesized that sofosbuvir might be a potential option to improve care of patients with COVID-19 especially at the start of the disease and before invasion of the virus into the lung paren…
  • [Chloroquine as a possible treatment for COVID-19]. [Journal Article]
    Ned Tijdschr Geneeskd. 2020 Mar 11; 164Coumou J, de Vries PJ
  • Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdes…
  • Ribonucleotide reductase small subunit M2 is a master driver of aggressive prostate cancer. [Journal Article]
    Mol Oncol. 2020 May 08 [Online ahead of print]Mazzu YZ, Armenia J, … Kantoff PW
  • Although there are molecularly distinct subtypes of prostate cancer, no molecular classification system is used clinically. The ribonucleotide reductase small subunit M2 (RRM2) gene plays an oncogenic role in many cancers. Our previous study elucidated comprehensive molecular mechanisms of RRM2 in prostate cancer (PC). Given the potent functions of RRM2, we set out to determine whether the RRM2 s…
  • Light-powered Escherichia coli cell division for chemical production. [Journal Article]
    Nat Commun. 2020 May 08; 11(1):2262.Ding Q, Ma D, … Chen X
  • Cell division can perturb the metabolic performance of industrial microbes. The C period of cell division starts from the initiation to the termination of DNA replication, whereas the D period is the bacterial division process. Here, we first shorten the C and D periods of E. coli by controlling the expression of the ribonucleotide reductase NrdAB and division proteins FtsZA through blue light an…
  • Novel coronavirus 2019 (COVID-19): A case report and review of treatments. [Case Reports]
    Medicine (Baltimore). 2020 May; 99(19):e20207.Douedi S, Miskoff J
  • CONCLUSIONS: With a rapidly growing death rate and more than 200,000 confirmed cases worldwide, COVID-19 has become a global pandemic and major hit to our healthcare systems. While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. The alarming increase in cases per day adds additional pressure to find a cure and decrease the global health burden and mortality rate.
  • Rapid review for the anti-coronavirus effect of remdesivir. [Review]
    Drug Discov Ther. 2020; 14(2):73-76.Li Z, Wang X, … Li G
  • The outbreak of SARS-CoV-2 rapidly spread across China and worldwide. Remdesivir had been proposed as a promising option for treating coronavirus disease 2019 (COVID-19). We provided a rapid review to critically assess the potential anti-coronavirus effect of remdesivir on COVID-19 and other coronaviruses based on the most up-to-date evidence. Even though remdesivir was proposed as a promising op…
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