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320,501 results
  • Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression. [Journal Article]
    Cell Host Microbe 2019; 26(2):217-227.e6Courtney DG, Tsai K, … Cullen BR
  • How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue has been the difficulty of quantifying these modifications. Using purified HIV-1 genomic RNA, we show that this RNA bears more epitranscriptomic modifications than the average cellular mRNA, with 5-methylcytosine (m5C) and 2'O-methyl modifications being pa…
  • Biomarker Identification Through Integrating fMRI and Epigenetics. [Journal Article]
    IEEE Trans Biomed Eng 2019Bai Y, Zille P, … Wang YP
  • CONCLUSIONS: This imaging epigenetics study has identified both brain regions and genes that are associated with neuron development and memory processing. These biomarkers contribute to a good understanding of the mechanism underlying SZ but are overlooked by previous imaging genetics studies.Our study sheds light on the understanding and diagnosis of SZ with a imaging epigenetics approach, which is demonstrated to be effective in extracting novel biomarkers associated with SZ.
  • Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats. [Journal Article]
    PLoS Genet 2019; 15(8):e1008136Li X, Jin X, … Lou H
  • The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels of replication threats remains elusive. Here, we have identified that a conserved GSK-3 kinase Mck1 cooperates with Dun1 in regulating this process. Deleting MCK1 sensitizes dun1Δ to hydroxyurea (HU) …
  • Ribonucleotide reductase from Fusarium oxysporum does not Respond to DNA replication stress. [Journal Article]
    DNA Repair (Amst) 2019; :102674Cohen R, Milo S, … Covo S
  • Ribonucleotide reductase (RNR) catalyzes the rate limiting step in dNTP biosynthesis and is tightly regulated at the transcription and activity levels. One of the best characterized responses of yeast to DNA damage is up-regulation of RNR transcription and activity and consequently, elevation of the dNTP pools. Hydroxyurea is a universal inhibitor of RNR that causes S phase arrest. It is used in …
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