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58,989 results
  • Quantitative modeling of transcription and translation of an all-E. coli cell-free system. [Journal Article]
    Sci Rep 2019; 9(1):11980Marshall R, Noireaux V
  • Cell-free transcription-translation (TXTL) is expanding as a polyvalent experimental platform to engineer biological systems outside living organisms. As the number of TXTL applications and users is rapidly growing, some aspects of this technology could be better characterized to provide a broader description of its basic working mechanisms. In particular, developing simple quantitative biophysic…
  • Conformational adaptation of UNCG loops upon crowding. [Journal Article]
    RNA 2019Meyer M, Walbott H, … Masquida B
  • If the A-form helix is the major structural motif found in RNA, the loops that cap them constitute the second most important family of motifs. Among those, two are over-represented, the GNRA and the UNCG tetraloops. Although one might think that these consensus sequences imply distinct and specific architectures, such is not the case. Recent surveys of RNA structures deposited in the PDB show tha…
  • Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport. [Review]
    Int J Mol Sci 2019; 20(16)Jiménez-González V, Ogalla-García E, … García-Quintanilla A
  • The Glutamate Receptor Ionotropic NMDA-Associated Protein 1 (GRINA) belongs to the Lifeguard family and is involved in calcium homeostasis, which governs key processes, such as cell survival or the release of neurotransmitters. GRINA is mainly associated with membranes of the endoplasmic reticulum, Golgi, endosome, and the cell surface, but its presence in the nucleus has not been explained yet. …
  • StatPearls: Histology, Basophilic Stippling [BOOK]
    StatPearls Publishing: Treasure Island (FL) Sanchez John R. JR Uniformed Services University Lynch David T. DT SAMMC BOOK
  • Basophilic stippling is one example of several clinically significant erythrocyte inclusions identified on peripheral blood smears. The presence of basophilic stippling is attributed to aggregates of ribosomes or fragments of ribosomal RNA precipitated throughout the cytoplasm of circulating erythrocytes. This finding is associated with acquired and heritable hematologic disorders affecting eryth…
  • Residue conservation elucidates the evolution of r-proteins in ribosomal assembly and function. [Journal Article]
    Int J Biol Macromol 2019Pilla SP, Bahadur RP
  • Ribosomes are the translational machineries having two unequal subunits, small subunit (SSU) and large subunit (LSU) across all the domains of life. Origin and evolution of ribosome are encoded in its structure, and the core of the ribosome is highly conserved. Here, we have used Shannon entropy to analyze the evolution of ribosomal proteins (r-proteins) across the three domains of life. Moreover…
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