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(ribosyl)
5,281 results
  • The Role of PARPs in Inflammation-and Metabolic-Related Diseases: Molecular Mechanisms and Beyond. [Review]
    Cells 2019; 8(9)Ke Y, Wang C, … Ba X
  • Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family. PARP1 plays a crucial role in multiple biological processes and PARP1 activation contributes to the development of various inflammatory and malignant disorders, includin…
  • Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation. [Journal Article]
    Mol Cell 2019Benabdallah NS, Williamson I, … Bickmore WA
  • Enhancers can regulate the promoters of their target genes over very large genomic distances. It is widely assumed that mechanisms of enhancer action involve the reorganization of three-dimensional chromatin architecture, but this is poorly understood. The predominant model involves physical enhancer-promoter interaction by looping out the intervening chromatin. However, studying the enhancer-dri…
  • c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes. [Journal Article]
    J Immunol 2019; 203(6):1521-1531Bohio AA, Sattout A, … Ba X
  • Poly(ADP-ribosyl)ation is a rapid and transient posttranslational protein modification mostly catalyzed by poly(ADP-ribose) polymerase-1 (PARP1). Fundamental roles of activated PARP1 in DNA damage repair and cellular response pathways are well established; however, the precise mechanisms by which PARP1 is activated independent of DNA damage, and thereby playing a role in expression of inflammator…
  • Poly-ADP ribosylation in DNA damage response and cancer therapy. [Review]
    Mutat Res 2019 Apr - Jun; 780:82-91Hou WH, Chen SH, Yu X
  • Poly(ADP-ribosyl)ation (aka PARylation) is a unique protein post-translational modification (PTM) first described over 50 years ago. PARylation regulates a number of biological processes including chromatin remodeling, the DNA damage response (DDR), transcription, apoptosis, and mitosis. The subsequent discovery of poly(ADP-ribose) polymerase-1 (PARP-1) catalyzing DNA-dependent PARylation spearhe…
  • Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation. [Journal Article]
    Acta Pharm Sin B 2019; 9(4):782-793Lu J, Li J, … Liu P
  • The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes. However, the effects of CHR׳s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this …
  • Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. [Journal Article]
    Nature 2019; 572(7769):382-386Bhogaraju S, Bonn F, … Dikic I
  • The family of bacterial SidE enzymes catalyses phosphoribosyl-linked serine ubiquitination and promotes infectivity of Legionella pneumophila, a pathogenic bacteria that causes Legionnaires' disease1-3. SidE enzymes share the genetic locus with the Legionella effector SidJ that spatiotemporally opposes the toxicity of these enzymes in yeast and mammalian cells, through a mechanism that is current…
  • Overview of the mammalian ADP-ribosyl-transferases clostridia toxin-like (ARTCs) family. [Journal Article]
    Biochem Pharmacol 2019; 167:86-96Di Girolamo M, Fabrizio G
  • Mono-ADP-ribosylation is a reversible post-translational protein modification that modulates the function of proteins involved in different cellular processes, including signal transduction, protein transport, transcription, cell cycle regulation, DNA repair and apoptosis. In mammals, mono-ADP-ribosylation is mainly catalyzed by members of two different classes of enzymes: ARTCs and ARTDs. The hu…
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