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588 results
  • Time To Revise COPD Treatment Algorithm. [Journal Article]
    Int J Chron Obstruct Pulmon Dis 2019; 14:2229-2234Matsunaga K, Oishi K, … Anzueto A
  • In 2017, a new two-step algorithm for the treatment of COPD was proposed. This algorithm was based on the severity of symptoms and phenotypes or treatable traits, and patient-specialised assessment targeting eosinophilic inflammation, chronic bronchitis, and frequent infections is recommended after exacerbation occurs despite maximal bronchodilation therapy. However, recent studies have revealed …
  • Phosphodiesterase inhibitors say NO to Alzheimer's disease. [Review]
    Food Chem Toxicol 2019; 134:110822Nabavi SM, Talarek S, … Farzaei MH
  • Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40 isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), the second messengers in cell functions. PDE inhibitors (PDEIs) have been attractive therapeutic targets due to their involvement in diverse medical conditions, e.g. cardiovascular diseases, autoimmune dise…
  • Optimizing Drug Therapies in Patients with COPD in the US Nursing Home Setting. [Review]
    Drugs Aging 2019; 36(8):733-745Pleasants RA, Radlowski PA, Davidson HE
  • Chronic obstructive pulmonary disease (COPD) can be a disabling disease, and the impact on older adults is particularly evident in the nursing home setting. Chronic obstructive pulmonary disease is present in about 20% of nursing home residents, most often in women, and accounts for significant healthcare utilization including acute care visits for exacerbations and pneumonia, as well as worsenin…
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