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571 results
  • Autoimmune thrombocytopenia: Current treatment options in adults with a focus on novel drugs. [Review]
    Eur J Haematol 2019Witkowski M, Witkowska M, Robak T
  • Immune thrombocytopenia (ITP) is an autoimmune disease characterized by platelet destruction and reduced platelet production resulting in decreased platelet level and an increased risk of bleeding. Based on the immunologic mechanism of ITP, front-line standard therapy consists of corticosteroids and intravenous immunoglobulins (IVIG). If patients do not respond to the first-line treatment, or if …
  • A Review of Growth Factor Support in Bloodless Autologous Hematopoietic Stem Cell Transplant. [Review]
    Biol Blood Marrow Transplant 2019; 25(10):e305-e309Zhao JC, Arnall JR, … Ford P
  • Bloodless autologous hematopoietic cell transplantation is associated with risks of severe bleeding and profound anemia. RBC or platelet transfusions are often used to prevent these hematologic complications. However, in patients such as Jehovah's Witnesses who refuse major blood components, the lack of transfusion support is not an absolute contraindication to an autologous hematopoietic cell tr…
  • Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage. [Case Reports]
    Case Rep Hematol 2019; 2019:5170282Nagaharu K, Masuya M, … Katayama N
  • Immune thrombocytopenic purpura (ITP) typically presents with bleeding due to immunologic thrombocytopenia. Severe hemorrhage due to ITP is sometimes lethal, and the urgent recovery of platelets is necessary. In addition to conventional therapeutic strategies, romiplostim shows promising efficacy for chronic ITP. However, there is little evidence for the utilization of this treatment for acute IT…
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