- Benzofuran-2-Acetic Esters as a New Class of Natural-Like Herbicides. [Journal Article]
- PMPest Manag Sci 2019 Jun 22
- CONCLUSIONS: Readily synthesizable benzofuran-2-acetic esters possessing the benzofuran ring as "bio-inspired" core, show significant herbicidal activity making them very efficient even at low concentrations. They can be sprayed in liquid form, and the addition of adjuvants can improve penetration through the leaf cuticle. These results confirm the importance of these molecules as models for the development of new natural-like herbicides. This article is protected by copyright. All rights reserved.
- Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling. [Journal Article]
- PlosPLoS One 2019; 14(6):e0218811
- Missense mutations in the human TUBB3 gene cause a variety of neurological disorders associated with defects in axon guidance and neuronal migration, but the underlying molecular mechanisms are not w…
Missense mutations in the human TUBB3 gene cause a variety of neurological disorders associated with defects in axon guidance and neuronal migration, but the underlying molecular mechanisms are not well understood. Recent studies have shown that direct coupling of dynamic TUBB3 in microtubules with netrin receptors is required for netrin-1-mediated axon guidance, and the interaction of netrin-1 repulsive receptor UNC5C with TUBB3 is involved in netrin-1 mediated axonal repulsion. Here, we report that TUBB3 mutations perturb netrin-1/UNC5C repulsive signaling in the developing nervous system. Among twelve mutants reported in previous studies, five of them show significantly reduced interaction with UNC5C in comparison to the wild-type TUBB3. TUBB3 mutants R262C and R62Q exhibit decreased subcellular colocalization with UNC5C in the peripheral area of the growth cone of primary mouse neurons. Netrin-1 reduces the colocalization of UNC5C with wild-type TUBB3, but not TUBB3 mutants R262C or R62Q, in the growth cone. Results from the in vitro cosedimentation assay indicate that netrin-1 inhibits cosedimentation of UNC5C with polymerized microtubules in primary mouse neurons expressing the wild-type TUBB3, but not R262C or R62Q. Expression of either R262C or R62Q not only blocks netrin-1-induced growth cone collapse and axonal repulsion of primary EGL cells in vitro, but also results in axon projections defects of chicken dorsal root ganglion neurons in ovo. Our study reveals that human TUBB3 mutations specifically perturb netrin-1/UNC5C-mediated repulsion.
- A worm in the cytology laboratory: A root cause analysis case study. [Journal Article]
- DCDiagn Cytopathol 2019 Jun 21
- In the spring of 2018, nematode-like organisms were first noted at the time of microscopic diagnosis on gynecologic (GYN) and anal pap specimens in our institution's cytopathology department. Due to …
In the spring of 2018, nematode-like organisms were first noted at the time of microscopic diagnosis on gynecologic (GYN) and anal pap specimens in our institution's cytopathology department. Due to their morphology and specimen source, we considered a diagnosis of pinworm. However, after identifying at least 30 more cases over 3 months from patients living in variable locations, we started favoring a contaminant. This report studies the steps that were initiated to figure the source of pap smear-preparation contamination and the molecular investigation to identify the nature of the contaminant.
- Fungal endophyte Phomopsis liquidambari biodegrades soil resveratrol: a potential allelochemical in peanut monocropping systems. [Journal Article]
- JSJ Sci Food Agric 2019 Jun 21
- CONCLUSIONS: Our results indicate that the practical application of the fungal endophyte P. liquidambari has a strong potential for biodegrading soil resveratrol, which can cause allelopathy in peanut continuous cropping systems. This article is protected by copyright. All rights reserved.
- Percutaneous Transforaminal Endoscopic Radiofrequency Ablation of the Sinuvertebral Nerve in an Olympian with a Left L5 Pedicle/Pars Interarticularis Fracture-Associated Left L5-S1 Disk Desiccation. [Case Reports]
- WNWorld Neurosurg X 2019; 3:100032
- CONCLUSIONS: It is important for clinicians to remember that back-associated leg pain can be caused by somatic referred pain because of irritation of the sinuvertebral nerve. Endoscopic radiofrequency of this nerve can be beneficial in pain control, but further randomized prospective trials are needed to study these techniques further.
- Molecular Docking Interaction Between Carotenoids and Curcumin and RAGE Receptor Prevents Diabetic Retinopathy Progression (P06-044-19). [Journal Article]
- CDCurr Dev Nutr 2019; 3(Suppl 1)
- CONCLUSIONS: RAGE may be of importance in the prevention and management of diabetes complications, and by instituting carotenoids and curcumin as a treatment, this may potentially decrease the progression of diabetes complications.
- Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease. [Review]
- CSClin Sci (Lond) 2019 Jun 28; 133(12):1321-1339
- Diabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in developed countries, with no defin…
Diabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in developed countries, with no definitive therapy yet available. It is imperative to decipher the exact mechanisms underlying DKD and identify novel therapeutic targets. Burgeoning evidence indicates that long non-coding RNAs (lncRNAs) are essential for diverse biological processes. However, their roles and the mechanisms of action remain to be defined in disease conditions like diabetes and DKD. The pathogenesis of DKD is twofold, so is the principle of treatments. As the underlying disease, diabetes per se is the root cause of DKD and thus a primary focus of therapy. Meanwhile, aberrant molecular signaling in kidney parenchymal cells and inflammatory cells may directly contribute to DKD. Evidence suggests that a number of lncRNAs are centrally involved in development and progression of DKD either via direct pathogenic roles or as indirect mediators of some nephropathic pathways, like TGF-β1, NF-κB, STAT3 and GSK-3β signaling. Some lncRNAs are thus likely to serve as biomarkers for early diagnosis or prognosis of DKD or as therapeutic targets for slowing progression or even inducing regression of established DKD. Here, we elaborated the latest evidence in support of lncRNAs as a key player in DKD. In an attempt to strengthen our understanding of the pathogenesis of DKD, and to envisage novel therapeutic strategies based on targeting lncRNAs, we also delineated the potential mechanisms of action as well as the efficacy of targeting lncRNA in preclinical models of DKD.
- Immobilization of Pb, Cu and Zn in contaminated soil using ball milling technique. [Journal Article]
- JCJ Contam Hydrol 2019 Jun 04; 225:103514
- Soil contamination caused by heavy metals has gained widespread attention from both government and public. In the present research, ball milling was utilized to remediate soil contaminated by Pb, Cu,…
Soil contamination caused by heavy metals has gained widespread attention from both government and public. In the present research, ball milling was utilized to remediate soil contaminated by Pb, Cu, and Zn and the influence of milling time on immobilization effectiveness was also investigated. The effectiveness of immobilization was evaluated by analyzing the leachable fraction of heavy metals from the ball-milled soil. When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg·L-1, 2.83 mg·L-1, and 114.42 mg·L-1 to 0.027 mg·L-1, 0.59 mg·L-1, and 0.16 mg·L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment. Furthermore, the leaching characteristics of Pb, Cu, and Zn were investigated through pH-dependent tests and those results indicated that mechanical treatment improved the anti-acid ability of soil. In addition, the BCR sequential extraction procedure revealed that speciation shiftsof heavy metals are the root cause for the reduction of leaching concentrations; after ball milling of 4 h, the primary components of Pb, Cu and Zn in the soil were relatively stable (F2 + F3) and residual fraction (F4), which accounted for 76.75%, 67.06% and 48.05% of total Pb, Cu and Zn, respectively.
- Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium. [Journal Article]
- SCStem Cells Dev 2019 Jun 19
- Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of to…
Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical loading. Severe periodontitis induces the destruction of periodontium and results in a significant cause of tooth loss among adults. Unfortunately, conventional therapies such as scaling and root planning are often only palliative. Therefore, the ultimate goal of the treatment for periodontitis is to restore disrupted periodontium to its original shape and function. Tissue engineering refers to the process of combining cells, scaffolds, and signaling molecules for the production of functional tissues to restore, maintain, and improve damaged organs. The discovery of PDL stem cells (PDLSCs) highlighted the possibility for development of tissue engineering technology-based therapeutics for disrupted periodontium. PDLSCs are a kind of somatic stem cells that show a potential to differentiate into multiple cell types and undergo robust clonal self-renewal. Therefore, PDLSCs are considered as a highly promising stem cell population for regenerative therapy in periodontium, however their rarity prevents the progression of basic and clinical researches. In this review, we summarize recent research advancement and accumulated information regarding the self-renewal capacity, multipotency, and immunomoduratory effect of PDLSCs, as well as their contribution to repair and regeneration of periodontium and other tissues. We also discuss the possibility of PDLSCs for clinical application of regenerative medicine and provide an outline of the genetic approaches to overcome the issue about the rarity of PDLSCs.
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- The role of globalization, real income, tourism in environmental sustainability target. Evidence from Turkey. [Journal Article]
- STSci Total Environ 2019 Jun 11; 687:423-432
- In this study, we examine the role of real income, globalization and tourism on environmental sustainability target by applying Autoregressive Distributed Lag (ARDL) bounds testing approach that cont…
In this study, we examine the role of real income, globalization and tourism on environmental sustainability target by applying Autoregressive Distributed Lag (ARDL) bounds testing approach that controls for structural breaks and Vector Error Correction Model (VECM) Granger causality approach that produces robust, efficient and reliable short-run and long-run estimates in the case of Turkey over the periods 1970-2014. To achieve our research objective, we examine stationarity properties of the series via unit root test after which we applied Bayer-Hanck combined cointegration technique to evaluate the presence of a long-run cointegration relationship among the series. The empirical results show that a 1% increase in real income level and international tourists' arrivals led to 0.625% and 0.129% increase in metric ton per capita CO2 emissions in the short-run and 0.345% and 0.071% increase in metric tons per capita CO2 emissions in the long-run, while globalization has non-significant negative impacts on CO2 emissions. The causality analysis suggest that tourism Granger causes CO2 emissions both in the short- and long-run, while real income and globalization only Granger cause CO2 emissions in the long-run. Findings also show that a one standard deviation shock to CO2 emissions has a noticeable positive and persistent impact on tourism, globalization and economic growth in the long-run.