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(root cause)
10,647 results
  • The world’s longest human tooth extracted [Journal Article]
    Swiss Dent J 2019; 129(10):817-820Lukas M, Ehlers V, Becker T
  • A patient with an abscess of the canine fossa starting from the tooth 13 turned up at the dental office. Such an abscess requires immediate and consistent surgical intervention to avoid potential lethal complications for the patient. The highlying swelling reaching the infraorbital area was quite impressive in this case. The panoramic radiograph that was taken (Fig. 1) revealed a canine of consid…
  • Growth parameters of Liberibacter crescens suggest ammonium and phosphate as essential molecules in the Liberibacter-plant host interface. [Journal Article]
    BMC Microbiol 2019; 19(1):222Cruz-Munoz M, Munoz-Beristain A, … Triplett EW
  • CONCLUSIONS: L. crescens and the Ca. Liberibacter pathogens are metabolically similar and grow in similar environments-the phloem and the gut of their insect vectors. The evaluation of the growth parameters of L. crescens reveals the lifestyle of Liberibacter, elucidating ammonium and phosphate as essential molecules for colonization within the hosts. Ammonium is the main driver of pH modulation by active deamination of amino acids in the L. crescens amino acid rich media. In plants, excess ammonium induces ionic imbalances, oxidative stress, and pH disturbances across cell membranes, causing stunted root and shoot growth and chlorosis-the common symptoms of HLB-disease. Phosphate, which is also present in Ca. L. asiaticus hosts, is the preferred buffer for the growth of L. crescens. The interplay between ammonium, sucrose, potassium (K+), phosphate, nitrate (NO3-), light and other photosynthates might lead to develop better strategies for disease management.
  • Acute commissural rupture in a giant aortic root aneurysm. [Journal Article]
    Ann Thorac Surg 2019Zhang J, Ma W, Kong Y
  • Idiopathic rupture of aortic valve commissure is an extremely rare cause of acute aortic regurgitation. Here, we reported one case of commissural rupture in the presence of a giant root aneurysm and a history of chronic aortic regurgitation, which emphasized the diagnostic value of high-quality 3-dimensional reconstructions of multimodality imaging in assessing the cause of abruptly deteriorating…
  • Genotoxic endpoints in a Pb-accumulating pea cultivar: insights into Pb2+ contamination limits. [Journal Article]
    Environ Sci Pollut Res Int 2019Rodriguez E, Sousa M, … Santos C
  • Lead (Pb) persists among the most hazardous contaminant metals. Pb-induced genotoxic effects remain a matter of debate as they are a major cause of plant growth impairment, but assessing Pb genotoxicity requires the selection of Pb-sensitive genotoxic biomarkers. Seedlings of the ecotoxicological model species Pisum sativum L. were exposed to Pb2+ (≤ 2000 mg L-1). Flow cytometry (FCM) revealed th…
  • Getting the most from after action reviews to improve global health security. [Review]
    Global Health 2019; 15(1):58Stoto MA, Nelson C, … Chungong S
  • CONCLUSIONS: Employing these practices requires a PHEP system that facilitates the preparation of insightful AARs, and more generally rewards learning. The barriers to AARs fall into two categories: concerns about the cultural sensitivity and context, liability, the political response, and national security; and constraints on staff time and the lack of experience and the requisite analytical skills. Ensuring that AARs fulfill their promise as tools of system improvement will require ongoing investment and a change in mindset. The first step should be to clarify that the goal of AARs is organizational learning, not placing blame or punishing poor performance. Based on experience in other fields, the buy-in of agency and political leadership is critical in this regard. National public health systems also need support in the form of toolkits, guides, and training, as well as research on AAR methods. An AAR registry could support organizational improvement through careful post-event analysis of systems' own events, facilitate identification and sharing of best practices across jurisdictions, and enable cross-case analyses.
  • Clinical experiences with the use of oxytocin injection by healthcare providers in a southwestern state of Nigeria: A cross-sectional study. [Journal Article]
    PLoS One 2019; 14(10):e0208367Ejekam CS, Okafor IP, … Nwokike J
  • CONCLUSIONS: The inappropriate and inconsistent use of oxytocin, especially overdosing, likely led to the high perception of medicine effectiveness among respondents. This is coupled with lack of suspicion of medicine ineffectiveness by clinicians as a possible root cause of poor treatment response or disease progression. Poor knowledge of oxytocin storage and consequent poor storage practices could have contributed to the ineffectiveness reported by some respondents. It is necessary to establish a unified protocol for oxytocin use that is strictly complied with. Continuous training of healthcare providers in medicine safety monitoring is advocated.
  • Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics. [Journal Article]
    Biometals 2019Shanmugavel KP, Kumar R, … Wittung-Stafshede P
  • Wilson disease (WD) is caused by mutations in the gene for ATP7B, a copper transport protein that regulates copper levels in cells. A large number of missense mutations have been reported to cause WD but genotype-phenotype correlations are not yet established. Since genetic screening for WD may become reality in the future, it is important to know how individual mutations affect ATP7B function, w…
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