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2,189 results
  • Natural Host-Induced Gene Silencing Offers New Opportunities to Engineer Disease Resistance. [Review]
    Trends Microbiol 2019Hou Y, Ma W
  • RNA silencing is an essential gene-regulation mechanism in eukaryotic organisms. Guided by small RNAs (sRNAs) of 20-25 nt in length, RNA silencing broadly governs a wide range of biological processes. In addition to regulating endogenous gene expression and inhibiting viral infection, accumulating evidence suggests that sRNAs can also function as antimicrobial agents against nonviral pathogens an…
  • One Small RNA of Fusarium graminearum Targets and Silences CEBiP Gene in Common Wheat. [Journal Article]
    Microorganisms 2019; 7(10)Jian J, Liang X
  • The pathogenic fungus Fusarium graminearum (F. graminearum), causing Fusarium head blight (FHB) or scab, is one of the most important cereal killers worldwide, exerting great economic and agronomic losses on global grain production. To repress pathogen invasion, plants have evolved a sophisticated innate immunity system for pathogen recognition and defense activation. Simultaneously, pathogens co…
  • Identification of the general stress stimulon related to colonization in Enterococcus faecalis. [Journal Article]
    Arch Microbiol 2019Salze M, Giard JC, … Muller C
  • Enterococcus faecalis has to cope with major stress conditions during colonization. To understand the effects of stress encountered during infection, the present study assessed the transcriptomic response of the bacteria facing exposure to serum, urine, bile salts, acid pH, or oxidative stress. Compared to non-stressed culture, 30% of the E. faecalis genes were differentially expressed. The trans…
  • SEAweb: the small RNA Expression Atlas web application. [Journal Article]
    Nucleic Acids Res 2019Rahman RU, Liebhoff AM, … Bonn S
  • We present the Small RNA Expression Atlas (SEAweb), a web application that allows for the interactive querying, visualization and analysis of known and novel small RNAs across 10 organisms. It contains sRNA and pathogen expression information for over 4200 published samples with standardized search terms and ontologies. In addition, SEAweb allows for the interactive visualization and re-analysis …
  • A rhlI 5' UTR-Derived sRNA Regulates RhlR-Dependent Quorum Sensing in Pseudomonas aeruginosa. [Journal Article]
    MBio 2019; 10(5)Thomason MK, Voichek M, … Greenberg EP
  • N-Acyl homoserine lactone (AHL) quorum sensing (QS) controls expression of over 200 genes in Pseudomonas aeruginosa There are two AHL regulatory systems: the LasR-LasI circuit and the RhlR-RhlI system. We mapped transcription termination sites affected by AHL QS in P. aeruginosa, and in doing so we identified AHL-regulated small RNAs (sRNAs). Of interest, we noted that one particular sRNA was loc…
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