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209 results
  • Rare cases of primary central nervous system anaplastic variant of diffuse large B-cell lymphoma. [Journal Article]
    Diagn Pathol 2019; 14(1):45Xu T, Jia Q, … Wang Z
  • CONCLUSIONS: These cases shed light on the unique genetic alterations and biological features of primary CNS A-DLBCL. Patients with primary CNS A-DLBCL may often have a MYC/BCL2 double-expressor and concurrent MYC and BCL2 and/or BCL6 genetic abnormalities, as well as constitutive activation of the NF-κB pathway. Primary CNS A-DLBCL follows a very aggressive disease course and poor prognosis. In the future, a large number of cases should be analyzed, and the evaluation of molecular genetic characteristics could help with practical and therapeutic implications for primary CNS A-DLBCL.
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