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(saquinavir)
2,088 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Protease Inhibitors (HIV) [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The human immunodeficiency virus (HIV) protease inhibitors are a broad class of agents that are widely used in the therapy and prevention of HIV infection and the acquired immunodeficiency syndrome (AIDS). All of the currently available protease inhibitors have been associated with transient and usually asymptomatic elevations in serum aminotransferase levels, and several (atazanavir, indinavir) …
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Saquinavir [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Saquinavir is an antiretroviral protease inhibitor that is used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Saquinavir can cause transient and usually asymptomatic elevations in serum aminotransferase levels and, rarely, can lead to clinically apparent acute liver injury. In HBV or HCV coinfected patients, highly…
  • StatPearls: Ritonavir [BOOK]
    StatPearls Publishing: Treasure Island (FL) Talha Bilal B Upstate University Dhamoon Amit S. AS SUNY Upstate Medical University BOOK
  • In the United States, the Food and Drug Administration (FDA) approved ritonavir in 1996 for the treatment of HIV. After saquinavir, it was the second approved protease inhibitor in the United States. Although ritonavir was initially designed to inhibit HIV protease, studies have found that it also inhibits cytochrome P450-3A4 (CYP450-3A4), which is its chief mechanism of action. It is currently u…
  • Application of agent-based modelling to assess single-molecule transport across the cell envelope of E. coli. [Journal Article]
    Comput Biol Med 2019; 107:218-226Maia P, Pérez-Rodríguez G, … Azevedo NF
  • CONCLUSIONS: This work presented a novel agent-based model to study the effect of the initial concentration of low molecular weight molecules on cellular noise. Cellular noise during molecule diffusion was found to be concentration-dependent and size-independent. The new model holds considerable potential for future, more complex analyses, when emerging experimental data may enable modelling of membrane transport mechanisms.
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