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172,044 results
  • Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. [Journal Article]
    Nat Commun 2019; 10(1):4317Garikipati VNS, Verma SK, … Kishore R
  • Circular RNAs are generated from many protein-coding genes, but their role in cardiovascular health and disease states remains unknown. Here we report identification of circRNA transcripts that are differentially expressed in post myocardial infarction (MI) mouse hearts including circFndc3b which is significantly down-regulated in the post-MI hearts. Notably, the human circFndc3b ortholog is also…
  • [Use of nanoparticles as radiosensitizing agents in radiotherapy: State of play]. [Journal Article]
    Cancer Radiother 2019Verry C, Porcel E, … Balosso J
  • Nanomedicine has undergone significant development since the 2000s and it is only very recently that two metallic nanoparticles have emerged in clinical trials. The mechanism of these radiosensitizing agents is based on the presence of atoms with a high atomic number (Z) allowing a higher dose deposition into the tumor during irradiation. The first nanoparticle used in humans is NBTXR3, composed …
  • Bilateral Thyroid Carcinosarcoma in a Cat. [Journal Article]
    J Comp Pathol 2019; 171:24-29Rich AF, Piviani M, … Blundell R
  • A neutered female domestic shorthaired cat was presented for a rapidly growing left cervical mass and a 6-month history of primary hyperthyroidism. Cytological examination of the mass was consistent with a sarcoma. Due to poor clinical response the cat was humanely destroyed and a post-mortem examination was performed. This revealed a markedly enlarged, irregularly shaped left thyroid gland with …
  • BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives. [Review]
    Cancers (Basel) 2019; 11(9)Crispo F, Notarangelo T, … Landriscina M
  • The Kirsten rat sarcoma viral oncogene homolog (RAS)/v-raf-1 murine leukemia viral oncogene homolog 1 (RAF)/mitogen-activated protein kinase 1 (MAPK) signaling cascade is the most important oncogenic pathway in human cancers. Tumors leading mutations in the gene encoding for v-raf murine sarcoma viral oncogene homolog B (BRAF) serine-threonine kinase are reliant on the MAPK signaling pathway for …
  • The treatment of Kaposi's sarcoma: present and future options, a review of the literature. [Journal Article]
    Eur Rev Med Pharmacol Sci 2019; 23(17):7488-7497Ceccarelli M, Facciolà A, … Venanzi Rullo E
  • Kaposi's Sarcoma (KS) is an angiogenic tumor involving skin, mucosa and splanchnic organs. It is caused by Human Herpes Virus 8 (HHV8), when in the presence of other cofactors, such as an immune dysregulation. KS is particularly frequent in HIV-infected individuals. The major goals of treatment are to prevent disease progression, to reduce tumor and edema, to avoid organ compromise, and to reliev…
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