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196 results
  • Inhaled GM-CSF for Pulmonary Alveolar Proteinosis. [Randomized Controlled Trial]
    N Engl J Med 2019; 381(10):923-932Tazawa R, Ueda T, … Nakata K
  • CONCLUSIONS: In this randomized, controlled trial, inhaled recombinant human GM-CSF was associated with a modest salutary effect on the laboratory outcome of arterial oxygen tension, and no clinical benefits were noted. (Funded by the Japan Agency for Medical Research and Development and the Ministry of Health, Labor, and Welfare of Japan; PAGE number, NCT02835742; Japan Medical Association Center for Clinical Trials number, JMA-IIA00205.).
  • Boosting Abscopal Response to Radiotherapy with Sargramostim: A Review of Data and Ongoing Studies. [Review]
    Cureus 2019; 11(3):e4276Leary R, Gardner RB, … Roychowdhury DF
  • Drug development in oncology today routinely focuses on approaches that utilize the patients' immune system to destroy the malignancy. Combinatorial approaches of antineoplastic agents, both new and old, are being incorporated in the armamentarium of cancer treatments. The overarching goal of therapy remains the achievement of a complete and durable response with long term remission or cure. One …
  • Monocytopenia in clozapine-induced agranulocytosis: insights into pathophysiology and treatment. [Case Reports]
    BMJ Case Rep 2019; 12(1)Patel R, Lima A, … Hoffman M
  • A 26-year-old man with history of schizophrenia was admitted for neutropaenia. He was started on clozapine 3 months prior to admission. As a result he had weekly monitoring of his blood counts and on day of admission was noted to have an absolute neutrophil count (ANC) of 450 cells/μL. He was admitted for clozapine-induced agranulocytosis. Clozapine was held and the patient was started on granulo…
  • An update on sargramostim for treatment of acute radiation syndrome. [Review]
    Drugs Today (Barc) 2018; 54(11):679-693Singh VK, Seed TM
  • The potential use by terrorists of an improvised nuclear device, a radiological dispersal device, or an unintended nuclear/radiological accident in heavily populated areas is a national security threat of major consequences. Although this type of security threat is considered to be low-risk, it would have a devastating impact. Health issues would be a major concern; medical care would be necessar…
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