- [Recurrent profuse hemorrhage in gastric angiodysplasia]. [Case Reports]
- KKhirurgiia (Mosk) 1999; (9):4-8
- Dieulafoy's disease--i.e. arteriovenous malformation--is a rare cause of gastric bleedings, which makes up 1.5-3% of all sources of hemorrhage. All the armory of diagnostic modalities may require to …
Dieulafoy's disease--i.e. arteriovenous malformation--is a rare cause of gastric bleedings, which makes up 1.5-3% of all sources of hemorrhage. All the armory of diagnostic modalities may require to reveal arteriovenous malformations. Angiography of the stomach appeared to be the most informative method for diagnosis of this disease in 2 patients. Radical treatment of patients with Dieulafoy's disease implies resection of the proximal part of the stomach or gastrectomy. Endoscopic hemostasis (with the use of coagulation and injections of sclerogenous preparations around the diseased area) results in temporary effect.
- Age-dependent changes of the kidneys: pharmacological implications. [Review]
- GGerontology 1999 Sep-Oct; 45(5):243-53
- About 40% of the intoxications after drug administration occur in the elderly. A significant proportion of the disease states in elderly patients is related to adverse reactions to prescribed drugs. …
About 40% of the intoxications after drug administration occur in the elderly. A significant proportion of the disease states in elderly patients is related to adverse reactions to prescribed drugs. Declining renal function, a reduction in both renal blood flow and glomerular filtration rate, is a major contributor to drug toxicity in the elderly. Therefore, a review (based on newer papers from Medline) of age-dependent changes of the kidneys and their consequences for drug therapy in geriatric patients is presented. Renal changes that occur with aging are: a decrease of renal weight, a thickening of the intrarenal vascular intima, sclerogenous changes of the glomeruli, and infiltration of chronic inflammatory cells and fibrosis in the stroma. Altered renal tubular function, including impaired handling of water, sodium, acid, and glucose, is also frequently present in old age. Impaired 'endocrinologic' functioning manifested by changes of the renin-angiotensin system, vitamin D metabolism, and antidiuretic hormone responsiveness has been reported. The aging kidney is constantly exposed to the effects of a variety of potential toxic processes, i.e., drugs and chronic illnesses including hypertension, diabetes, and atherosclerotic disease. Renal changes that occur with aging also consist of impairment in the ability to concentrate urine and to conserve sodium and water. These physiological changes increase the risks of volume depletion and prerenal type of acute renal failure. A frequent cause of acute renal failure in the elderly is drug-induced nephropathy. Nonsteroidal anti-inflammatory drugs, antibiotics, and diuretics are most often involved. Due to the age-dependent decline of renal function, the pharmacokinetics of many drugs are altered in elderly patients. Therefore, the most important renal function to monitor with aging is the creatinine clearance. Changes in pharmacokinetics of many drugs and most decisions on drug dosage can be based on this information alone, as tubular functions of the kidney decrease at rates paralleling the age-dependent decrease in glomerular filtration rate (which is approximately measured by the creatinine clearance). As a conclusion, age-dependent changes of renal function are not only responsible for changes in pharmacokinetics and pharmacodynamics. In many cases, the kidneys are the target organ of adverse drug reactions too.
- [Age-related changes in morphological studies in rat and human kidney]. [Journal Article]
- NJNihon Jinzo Gakkai Shi 1996; 38(12):555-62
- There have been many reports on changes in renal morphology with aging. In this study, morphological comparisons were made on the influence of aging in humans and rats. Kidneys were obtained from 63 …
There have been many reports on changes in renal morphology with aging. In this study, morphological comparisons were made on the influence of aging in humans and rats. Kidneys were obtained from 63 autopsies (except those from cases of tumor, severe cicatrization, and cysts 10 mm or more in diameter) performed on humans aged from 0 to 92 years, including 7 cases with a past history of hypertension; the findings were compared with those from 201 Wistar male rats aged three to 115 weeks. First, changes in renal weight and renal cortex width were investigated. Next, changes in renal morphology were examined by microscopy. Finally, after performing alcian-blue-PAS staining, the ratio of the intima/outer diameter (I/OD ratio) of renal blood vessel was measured under a microscope with an image analyzer, and the results compared. A decrease in renal weight was observed in humans from about 50 years of age, but there was no decrease in weight with aging among rats. While significant thickening in the vascular intima was observed with aging in humans, there was no such thickening among rats. Furthermore, the presence of hypertension caused renal cortex width to be significantly decreased in humans (p < 0.04). Findings of sclerogenous changes of the glomeruli, infiltration of chronic inflammatory cells and fibrosis in the stroma, and tubular casts were observed with aging in both humans and rats. In conclusion, arteriosclerosis apparently develops with aging in humans, suggesting that arteriosclerosis greatly influences the reduction of human renal weight.
- Conservative management of posttraumatic cervical intersegmental hypermobility and anterior subluxation. [Case Reports]
- JMJ Manipulative Physiol Ther 1995; 18(5):315-21
- CONCLUSIONS: Conservative chiropractic management of hyperflexion injuries may be useful in reducing clinical symptoms, cervical hypolordosis, anterior subluxation and intersegmental hypermobility, as seen in follow-up radiographs. Chiropractic sports physicians have the diagnostic and therapeutic expertise to manage these types of athletic injuries.
- Lichen sclerosus et atrophicus causing phimosis in boys: a prospective study with 5-year followup after complete circumcision. [Journal Article]
- JUJ Urol 1994; 152(3):987-9
- We prospectively investigated 100 pediatric patients suffering from phimosis and found a 10% incidence of lichen sclerosus et atrophicus. This condition usually can be diagnosed preoperatively becaus…
We prospectively investigated 100 pediatric patients suffering from phimosis and found a 10% incidence of lichen sclerosus et atrophicus. This condition usually can be diagnosed preoperatively because of its classic manifestation of severe phimosis due to a sclerotic, whitish ring at the tip of the prepuce, which in our cases was accompanied by sclerogenous glanular lesions. To our knowledge our study represents the first evidence that the development of secondary phimosis with no apparent reason in school-age boys is highly suggestive for lichen sclerosus et atrophicus. Complete circumcision is the therapy of choice because it completely removes all affected tissue and it allows spontaneous regression or resolution of glanular lesions. There has been no recurrence after 5 years of followup.
- [The morphological characteristics of the cardiac lymphatic bed in chronic coronary failure]. [Journal Article]
- VDVrach Delo 1990; (7):45-7
- A study is presented of the morphological changes of the lymphatic circulation in chronic ischemic heart disease (IHD). Examinations were carried out on clinical material: intraoperative cardiac biop…
A study is presented of the morphological changes of the lymphatic circulation in chronic ischemic heart disease (IHD). Examinations were carried out on clinical material: intraoperative cardiac biopsies and on hearts of patients who died of this disease at the age of 36-59 years. Transmission electron microscopy was used. A clinical comparison was realized of changes of intramyocardial and subepicardial regions of the heart lymph circulation and morphological equivalents of disorders of outflow of lymph from the heart in chronic IHD were evaluated. The obtained data indicate the lymph stasis possessing cardiotoxic and sclerogenous properties is an essential pathogenetic factor of myocardial fibrotization in chronic coronary insufficiency.
- Research on viral hepatitis performed in the "Stefan S. Nicolau" Institute of Virology. [Review]
- VVirologie 1979 Oct-Dec; 30(4):257-66
- The first phase of research on viral hepatitis (VH) performed in the Institute of Virology (1949--1967) consisted of etiopathogenic, clinico-epidemiological and histopathological investigations which…
The first phase of research on viral hepatitis (VH) performed in the Institute of Virology (1949--1967) consisted of etiopathogenic, clinico-epidemiological and histopathological investigations which outlined the concepts of VH plurietiology, of infravirus, as well as the characteristic symptomatic triad, the "age group" phenomenon, the clinico-morphological characteristics of sclerogenous hepatitis. The 2nd research phase was mainly devoted to the study of the distribution, properties and clinico-epidemiological correlations of HBsAg. The application of a modern methodology confirmed many of the previously obtained results.
- [Sclerogenous peritonitis: an unusual complication in the treatment of chronic conditions with practolol (author's transl)]. [Journal Article]
- ACAnn Cardiol Angeiol (Paris) 1976 Mar-Apr; 25(2):137-9
- [Biopsy of the pericardium. Diagnostic value in subacute and chronic pericarditis, apropos of 70 cases]. [Journal Article]
- AMArch Mal Coeur Vaiss 1975; 68(1):11-7
- The aetiology of pericarditis is often difficult to assess. To try to clear up this problem, a pericardial biopsy through a left lateral thoracotomy was performed in 70 cases in which the cause could…
The aetiology of pericarditis is often difficult to assess. To try to clear up this problem, a pericardial biopsy through a left lateral thoracotomy was performed in 70 cases in which the cause could not be established by the usual means (including pericardial paracenthesis in 32 cases). They included either subacute pericarditis, dry or with effusion (biopsy being undertaken as an average 45 days after the clinical onset), or chronic pericarditis with effusion. Tuberculosis was thus demonstrated in 14 cases (8 of which were aged more than 60 years), inaugural pericardial tumours in 8 and suppuration in 3 cases. Microscopical examination gave support to pathogenic hypotheses concerning cholesterol pericarditis (5 cases) and multi-recurrent pericartitides (6 cases). By elimination with a high probability) of tuberculosis and tumours, it demonstrated definitely the diagnosis of post-radiotherapy pericarditis with effusion (4 cases) pericarditis with normal serous membrane (4 cases) and "idiopathic" forms (23 cases of common sclerogenous subacute inflammation). The inocuity of this method, its more accurate results than those obtained by cytological and bacteriological examination of the pericardial fluid obtained by paracenthesis, should induce to consider this procedure more often in the cases of pericarditis when the aetiology remains doubtful; not to mention the benefit derived from surgical drainage which results in a quicker and more complete cure than repeated paracentheses of chronic and subacute pericardial effusions.
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- [Sclerogenous cholostatic hepatitis]. [Journal Article]
- MMMaroc Med 1959; 38:1081-5