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407 results
  • The epidemiology of osteoporosis. [Journal Article]
    Br Med Bull. 2020 May 15; 133(1):105-117.Clynes MA, Harvey NC, … Cooper C
  • CONCLUSIONS: As with all new interventions, we await the results of long-term use of osteoporosis screening algorithms and how these can be refined and incorporated into clinical practice.Despite advances in osteoporosis screening, a minority of men and women at high fracture risk worldwide receive treatment. The economic and societal burden caused by osteoporosis is a clear motivation for improving the screening and management of osteoporosis worldwide.
  • A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor. [Journal Article]
    Elife. 2020 Mar 13; 9Sagert L, Hennig F, … Tampé R
  • Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR. An important catalytic role has been ascribed to a structural feature in TAPBPR called the scoop loop, but the exact function of the scoop loop remains…
  • The Effect of Topical Anaesthesia on the Cortisol Responses of Calves Undergoing Dehorning. [Journal Article]
    Animals (Basel). 2020 Feb 17; 10(2)Espinoza C, Lomax S, Windsor P
  • Dehorning causes pain and distress to cattle, and there is a need to provide effective and practical analgesia to improve animal welfare. We conducted an experiment to determine the effect of a modified post-operative topical wound management formulation containing two local anaesthetics (TA) on the plasma cortisol concentration (PCC) of scoop-dehorned calves. Two months old Holstein-Friesian hei…
  • Framing climate change and health: New Zealand's online news media. [Journal Article]
    Health Promot Int. 2020 Jan 31 [Online ahead of print]Harrison S, Macmillan A, Rudd C
  • Climate change is a major threat to public health worldwide. Conversely, well-designed action to mitigate climate change offers numerous opportunities to improve health and equity. Despite this, comprehensive climate action has not been forthcoming within New Zealand. The media plays an important role in shaping public opinion and support for policy change. Previous literature has suggested that …
  • The scoop on brain health dietary supplement products containing huperzine A. [Journal Article]
    Clin Toxicol (Phila). 2020 Jan 28 [Online ahead of print]Crawford C, Wang YH, … Deuster PA
  • CONCLUSIONS: In a study of dietary supplements claiming to contain huperzine A, we found products that had at least one ingredient claimed on the supplement facts label not detected through analysis. Moreover, some ingredients not on the label could be dangerous and likely do not meet the definition of a dietary supplement ingredient according to the FDA. Quantitative analysis of huperzine A showed the amount detected was not in line with what appeared on the product label. Consumers should be aware of deceptive label claims and warned not to purchase products containing potentially dangerous ingredients.
  • Prehospital trauma care evolution, practice and controversies: need for a review. [Journal Article]
    Int J Inj Contr Saf Promot. 2020 Mar; 27(1):69-82.Varghese M
  • Modern medicine and surgery is historically very recent, and most interventions that are so commonly done in a hospital now are only 60 to 70 years old. Understanding of emergency care of the injured is more recent; however, for the sake of temporal convenience trauma care has become compartmentalized into phases: first aid, bystander care, prehospital care, emergency care, definitive levels of c…
  • Child feces management practices and fecal contamination: A cross-sectional study in rural Odisha, India. [Journal Article]
    Sci Total Environ. 2020 Mar 20; 709:136169.Bauza V, Majorin F, … Clasen T
  • Safe child feces management (CFM) is likely critical for reducing exposure to fecal pathogens in and around the home, but the effectiveness of different CFM practices in reducing fecal contamination is not well understood. We conducted a cross-sectional study of households with children <6 years in rural Odisha, India, using household surveys (188 households), environmental sample analysis (373 s…
  • Fracture prevention by screening for high fracture risk: a systematic review and meta-analysis. [Review]
    Osteoporos Int. 2020 Feb; 31(2):251-257.Merlijn T, Swart KMA, … Elders PJM
  • This systematic review and meta-analysis showed a significant reduction of (major) osteoporotic fractures and hip fractures after screening using fracture risk assessment and bone densitometry compared with usual care. The results indicate that screening is effective for fracture risk reduction, especially hip fractures. To perform a systematic review and meta-analysis of population screening for…
  • An Unusual Extender Unit Is Incorporated into the Modular Polyketide Synthase of Scopranones Biosynthesis. [Journal Article]
    Biochemistry. 2019 12 17; 58(50):5066-5073.Demachi A, Uchida R, … Ikeda H
  • Scopranones, produced by Streptomyces sp. BYK-11038, are the novel bone morphogenetic protein inhibitors characterized by atypical two scoop-like moieties and a 3-furanone moiety. Two scoop-like moieties connected to a 3-furanone have not previously been reported in natural products, and their biosynthesis must occur via a unique pathway. Feeding experiments using 13C-labeled precursors indicated…
  • Owner and Cat-Related Risk Factors for Feline Overweight or Obesity. [Journal Article]
    Front Vet Sci. 2019; 6:266.Wall M, Cave NJ, Vallee E
  • Feline obesity is a highly prevalent disease that poses an urgent and serious challenge. Attempted treatment by weight reduction is often unsuccessful; a new preventative approach that focuses on the role of the owner may be helpful. This study used data collected from an international survey of cat owners designed to assess owner personality and self-control, owner-pet attachment, feeding practi…
  • Dog owner's accuracy measuring different volumes of dry dog food using three different measuring devices. [Journal Article]
    Vet Rec. 2019 11 16; 185(19):599.Coe JB, Rankovic A, … Parr JM
  • Prior research demonstrates significant inaccuracy when repeatedly measuring the same amount of dry dog food using a dry-food measuring cup, bringing into question the accuracy of measuring devices. This study aimed to determine dog owners' accuracy when measuring different volumes of dry dog food using different types of measuring devices. One hundred dog owners, randomly assigned one of three m…
  • Design and Evaluation of a Novel Hybrid Soft Surgical Gripper for Safe Digital Nerve Manipulation. [Journal Article]
    Micromachines (Basel). 2019 Mar 15; 10(3)Guo J, Low JH, … Yeow CH
  • Forceps are essential tools for digital nerve manipulation during digital nerve repair surgery. However, surgeons have to operate forceps with extreme caution to prevent detrimental post-operative complications caused by over-gripping force. Their intrinsically safe characteristics have led to the increasing adoption of soft robotics in various biomedical applications. In this paper, a miniaturiz…
  • Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin. [Journal Article]
    Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5055-5060.Hafstrand I, Sayitoglu EC, … Achour A
  • MHC-I epitope presentation to CD8+ T cells is directly dependent on peptide loading and selection during antigen processing. However, the exact molecular bases underlying peptide selection and binding by MHC-I remain largely unknown. Within the peptide-loading complex, the peptide editor tapasin is key to the selection of MHC-I-bound peptides. Here, we have determined an ensemble of crystal struc…
  • Bili-Uéré: A Chimpanzee Behavioural Realm in Northern Democratic Republic of Congo. [Journal Article]
    Folia Primatol (Basel). 2019; 90(1):3-64.Hicks TC, Kühl HS, … Roessingh P
  • To improve our understanding of the evolutionary origins of culture and technology in humans, it is vital that we document the full extent of behavioural diversity in our great ape relatives. About half of the world's remaining chimpanzees (Pan spp.) live in the Democratic Republic of Congo (DRC), yet until now we have known almost nothing about their behaviour. Here we describe the insect-relate…
  • Philip Henry Mules (1843-1905) and his innovations in ocular surgery. [Historical Article]
    Acta Chir Belg. 2019 Jun; 119(3):198-200.Laios K, Charalampakis A, … Moschos MM
  • CONCLUSIONS: Philip Henry Mules (1843-1905) was a respectable English ophthalmologist, who despite his short life, only 62-years-old, his innovations in ocular surgery were considered a breakthrough in the late nineteenth century, because in almost every textbook of ophthalmology they were cited and deserved a great merit.
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