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28,447 results
  • Investigation of singular ordinary differential equations by a neuroevolutionary approach. [Journal Article]
    PLoS One. 2020; 15(7):e0235829.Waseem W, Sulaiman M, … Islam S
  • In this research, we have investigated doubly singular ordinary differential equations and a real application problem of studying the temperature profile in a porous fin model. We have suggested a novel soft computing strategy for the training of unknown weights involved in the feed-forward artificial neural networks (ANNs). Our neuroevolutionary approach is used to suggest approximate solutions …
  • Stable individual differences in strategies within, but not between, visual search tasks. [Journal Article]
    Q J Exp Psychol (Hove). 2020 Jul 09 [Online ahead of print]Clarke AD, Irons JL, … Hunt AR
  • A striking range of individual differences has recently been reported in three different visual search tasks. These differences in performance can be attributed to strategy, that is, the efficiency with which participants control their search to complete the task quickly and accurately. Here, we ask whether an individual's strategy and performance in one search task is correlated with how they pe…
  • A mobile robotic chemist. [Journal Article]
    Nature. 2020 Jul; 583(7815):237-241.Burger B, Maffettone PM, … Cooper AI
  • Technologies such as batteries, biomaterials and heterogeneous catalysts have functions that are defined by mixtures of molecular and mesoscale components. As yet, this multi-length-scale complexity cannot be fully captured by atomistic simulations, and the design of such materials from first principles is still rare1-5. Likewise, experimental complexity scales exponentially with the number of va…
  • Provision of medical assistance in dying: a scoping review. [Journal Article]
    BMJ Open. 2020 Jul 08; 10(7):e036054.Zworth M, Saleh C, … Oczkowski S
  • CONCLUSIONS: We identified several trends in MAID provision including common medications and doses for oral and parenteral administration, roles of healthcare professionals and families, and complications that may cause patient, family and provider distress. Future research should aim to identify the medications, dosages, and administration techniques and procedures that produce the most predictable outcomes and mitigate distress for those involved.
  • Inclusion of surgical antibiotic regimens in pediatric urology publications: A systematic review. [Journal Article]
    J Pediatr Urol. 2020 Jun 09 [Online ahead of print]Snyder E, Mohan C, … Ross S
  • CONCLUSIONS: Surgical antibiotic regimens and infection outcomes are infrequently included in pediatric urology studies, limiting the data available for development of evidence-based guidelines. Routine incorporation of antibiotic regimens, infection outcomes and adverse events in the pediatric urology literature will increase our ability to identify indications for antibiotics. Reporting of perioperative antibiotic outcomes in pediatric urology procedures will allow the eventual development of strong evidence-based guidelines.
  • The Effect of Hearing Loss and Hearing Device Fitting on Fatigue in Adults: A Systematic Review. [Journal Article]
    Ear Hear. 2020 Jul 02 [Online ahead of print]Holman JA, Drummond A, Naylor G
  • CONCLUSIONS: As the studies were too heterogeneous to support a meta-analysis, it was not possible to provide statistically significant evidence to support the hypotheses that hearing loss results in increased fatigue (H1) or that hearing device fitting results in decreased fatigue (H2). Despite this, the comparative volume of positive results and the lack of any negative findings are promising for future research (particularly in respect of Q1). There was a very small number of studies deemed eligible for the review, and there was large variability between studies in terms of population, and quantification of hearing loss and fatigue. The review highlights the need for consistency when measuring fatigue, particularly when using self-report questionnaires, where the majority of the current evidence was generated.
  • Patients with asthma have a higher risk of systemic lupus erythematosus: a systematic review and meta-analysis. [Journal Article]
    Clin Rheumatol. 2020 Jul 07 [Online ahead of print]Charoenngam N, Ponvilawan B, … Ungprasert P
  • CONCLUSIONS: The current study found a significant association between asthma and increased risk of SLE. Key Points • Studies have suggested an elevated risk of systemic lupus erythematosus among patients with asthma; however, the results from existing studies are inconsistent. • This meta-analysis included data from three cohort studies and seven case--control studies. • A significant association between asthma and elevated risk of systemic lupus erythematosus was observed, with the pooled odds ratio of 1.37 (95% CI 1.14-1.65; I267%).
  • Management of skin adverse reactions in oncology. [Journal Article]
    J Oncol Pharm Pract. 2020 Jul 07 [Online ahead of print]Silva D, Gomes A, … Almeida IF
  • Chemo and targeted anticancer therapies present significant skin adverse reactions, which impair the patients' quality of life. Cutaneous toxicities lead to poor treatment adherence, drug cessation, and psychosocial distress. This review aims to summarize the current knowledge concerning the prevention and management of skin toxicity arising from these therapies. A systematic literature search on…
  • Application of Artificial Intelligence in COVID-19 drug repurposing. [Review]
    Diabetes Metab Syndr. 2020 Jul 03; 14(5):1027-1031.Mohanty S, Harun Ai Rashid M, … Swayamsiddha S
  • CONCLUSIONS: Thus, there are chances that the application of the AI approach in drug discovery is feasible. With prior usage experiences in patients, few of the old drugs, if shown active against SARS-CoV-2, can be readily applied to treat the COVID-19 patients. With the collaboration of AI with pharmacology, the efficiency of drug repurposing can improve significantly.
  • Multidisciplinary approaches to the management of malignant pleural effusions: a guide for the clinician. [Journal Article]
    Expert Rev Respir Med. 2020 Jul 07 [Online ahead of print]Banka R, George V, Rahman NM
  • Malignant pleural effusion (MPE) is a complication of advanced cancer, associated with significant mortality and morbidity. This entity is commonly treated by respiratory physicians, oncologists and thoracic surgeons. There have been various randomised clinical trials assessing the relative merits of chest drain pleurodesis, indwelling pleural catheters, treatment of septated MPEs, the use of tho…
  • Hydration for health hypothesis: a narrative review of supporting evidence. [Review]
    Eur J Nutr. 2020 Jul 06 [Online ahead of print]Perrier ET, Armstrong LE, … Péronnet F
  • CONCLUSIONS: In order to ensure optimal hydration, it is proposed that optimal total water intake should approach 2.5 to 3.5 L day-1 to allow for the daily excretion of 2 to 3 L of dilute (< 500 mOsm kg-1) urine. Simple urinary markers of hydration such as urine color or void frequency may be used to monitor and adjust intake.
  • Diversity-guided Lamarckian random drift particle swarm optimization for flexible ligand docking. [Journal Article]
    BMC Bioinformatics. 2020 Jul 06; 21(1):286.Li C, Sun J, Palade V
  • CONCLUSIONS: The DGLRDPSO algorithm has good search performance and a high possibility of finding a conformation with both a low binding free energy and a small RMSD. Among all the tested algorithms, DGLRDPSO has the best robustness in solving both holo- and apo-structure docking problems with different numbers of torsions, which indicates that the proposed algorithm is a reliable choice for the flexible ligand docking in Autodock software.
  • Guipi decoction for insomnia: Systematic review and meta-analysis. [Journal Article]
    Medicine (Baltimore). 2020 Jul 02; 99(27):e21031.Li M, Lan R, … Yang D
  • CONCLUSIONS: The conclusion of this systematic review will provide evidence to judge whether Guipi Decoction is an effective therapeutic intervention for patient with insomnia. Maybe these results could potentially be helpful for improving the therapeutic strategy of patients with insomnia.
  • Monodisperse and polydisperse PEGylation of peptides and proteins: a comparative study. [Journal Article]
    Biomacromolecules. 2020 Jul 06 [Online ahead of print]Wang J, Deng T, … Jiang ZX
  • Although PEGylation is widely used in biomedicine with great success, it suffers many drawbacks, such as polydispersity, non-biodegradability, and loss of precursor potency. Recently, the search for polyethylene glycols (PEGs) substitutes has attracted considerable attention. Some of the substitutes partially address the drawbacks of PEGs, but sacrifice the "stealth" effect of PEGs and bring in n…
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