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1,317 results
  • Histo-blood group antigens and rotavirus vaccine shedding in Nicaraguan infants. [Journal Article]
    Sci Rep 2019; 9(1):10764Bucardo F, Reyes Y, … Nordgren J
  • ABO, Lewis and secretor histo-blood group antigens (HBGA) are susceptibility factors for rotavirus in a P-genotype dependent manner and can influence IgA seroconversion rates following rotavirus vaccination. To investigate the association between HBGA phenotypes and rotavirus vaccine shedding fecal samples (n = 304) from a total of 141 infants vaccinated with Rotarix (n = 71) and RotaTeq (n = 70)…
  • The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition. [Review]
    Pediatr Gastroenterol Hepatol Nutr 2019; 22(4):330-340Hegar B, Wibowo Y, … Vandenplas Y
  • Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulatio…
  • Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens. [Journal Article]
    PLoS Pathog 2019; 15(6):e1007865Gozalbo-Rovira R, Ciges-Tomas JR, … Rodríguez-Díaz J
  • Rotavirus is the leading agent causing acute gastroenteritis in young children, with the P[8] genotype accounting for more than 80% of infections in humans. The molecular bases for binding of the VP8* domain from P[8] VP4 spike protein to its cellular receptor, the secretory H type-1 antigen (Fuc-α1,2-Gal-β1,3-GlcNAc; H1), and to its precursor lacto-N-biose (Gal-β1,3-GlcNAc; LNB) have been determ…
  • Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants. [Journal Article]
    Nutrients 2019; 11(6)Austin S, De Castro CA, … Fischer Fumeaux CJ
  • Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual…
  • Integrated Analysis of Human Milk Microbiota With Oligosaccharides and Fatty Acids in the CHILD Cohort. [Journal Article]
    Front Nutr 2019; 6:58Moossavi S, Atakora F, … Azad MB
  • CONCLUSIONS: Using multiple approaches to integrate and analyse milk microbiota, oligosaccharides, and fatty acids, we observed several associations between different milk components and microbiota, some of which were modified by secretor status and/or breastfeeding practices. Additional research is needed to further validate and mechanistically characterize these associations and determine their relevance to infant gut and respiratory microbiota development and health.
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