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(septal myectomy)
840 results
  • Dual-Chamber pacing for postoperative residual left ventricular gradient after aortic valve replacement and concomitant septal myectomy for severe aortic stenosis and subvalvular obstruction. [Case Reports]
    J Cardiol Cases. 2020 Jul; 22(1):15-18.Imafuku H, Komatsu J, … Doi Y
  • CONCLUSIONS: Dual-chamber pacing was extremely effective in reducing residual mid ventricular gradient in a patient who underwent aortic valve replacement and concomitant septal myectomy for severe aortic stenosis and subvalvular obstruction.<Learning objective: Dual-chamber pacing was extremely effective in reducing residual mid-ventricular pressure gradient in a 69-year-old woman with antecedent aortic valve replacement and concomitant septal myectomy for severe aortic stenosis and subvalvular obstruction.Dual-chamber pacing may have the potential to become one of the non-surgical therapeutic options for those with post-surgical residual subvalvular gradient, not only for severe aortic stenosis and subvalvular obstruction but also for obstructive hypertrophic cardiomyopathy.>.
  • Transcatheter closure of complex iatrogenic ventricular septal defect: a case report. [Case Reports]
    Eur Heart J Case Rep. 2020 Jun; 4(3):1-5.Barioli A, Cardaioli F, … Tarantini G
  • Iatrogenic membranous ventricular septal defects (VSDs) are rare complications of cardiothoracic surgery, such as septal myectomy for hypertrophic obstructive cardiomyopathy (HOCM). Transcatheter closure is considered an appealing alternative to surgery, given the increased mortality associated with repeated surgical procedures, but reports are extremely limited.
  • Effects of surgical septal myectomy on survival in patients with hypertrophic obstructive cardiomyopathy. [Journal Article]
    Anatol J Cardiol. 2020 06; 23(6):342-348.Meng X, Liang M, … Gao C
  • CONCLUSIONS: Patients with HOCM undergoing myectomy appeared to suffer from a lower risk of reaching the all-cause mortality and demonstrated statistically indistinguishable overall survival compared with patients with nonobstructive HCM. Multivariate analysis clearly demonstrated myectomy as a powerful, independent factor of survival, confirming that the differences in long-term survival recorded in this study may be due to surgical improvement in the LVOT gradient.
  • Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19. [Journal Article]
    Mayo Clin Proc. 2020 Apr 28 [Online ahead of print]Bos JM, Hebl VB, … Ackerman MJ
  • CONCLUSIONS: More than 20% of the transcriptome is expressed differentially between HCM and control tissues. Importantly, ACE2 was the most up-regulated gene in HCM, indicating perhaps the heart's compensatory effort to mount an antihypertrophic, antifibrotic response. However, given that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses ACE2 for viral entry, this 5-fold increase in ACE2 protein may confer increased risk for COVID-19 manifestations and outcomes in patients with increased ACE2 transcript expression and protein levels in the heart.
  • Anomalous papillary muscles-Implications in the surgical treatment of hypertrophic obstructive cardiomyopathy. [Journal Article]
    J Thorac Cardiovasc Surg. 2020 Apr 15 [Online ahead of print]Lentz Carvalho J, Schaff HV, … Dearani JA
  • CONCLUSIONS: Papillary muscle abnormalities are important findings in patients with obstructive hypertrophic cardiomyopathy but are not identified preoperatively in the majority of patients. Recognition of anomalous papillary muscles intraoperatively and understanding of the morphologic subtypes are critical to adequate gradient relief and preservation of mitral valve function. The optimum approach involves a transaortic extended septal myectomy associated with the resection of the anomalous papillary muscles in patients with type I and II anatomy.
  • Edge-to-edge mitral repair associated to septal myectomy in hypertrophic obstructive cardiomyopathy. [Journal Article]
    Ann Thorac Surg. 2020 May 07 [Online ahead of print]Lapenna E, Nisi T, … De Bonis M
  • CONCLUSIONS: In HOCM patients, when septal thickness was considered inadequate to allow a safe and effective myectomy, the EE technique provided a simple, quick and effective solution by abolishing at the same time residual gradient and SAM-related MR. Organic MV lesions such as prolapse/flail could be addressed as well, whenever indicated. Satisfactory clinical and echocardiographic results were maintained at long-term follow-up.
  • Cardiac AA amyloidosis in a patient with obstructive hypertrophic cardiomyopathy. [Case Reports]
    Cardiovasc Pathol. 2020 Mar 07; 48:107218.Li B, Ahluwalia M, … Sherrid MV
  • Cardiac amyloid A (AA) amyloidosis is rare. We present the case of a 72-year-old woman with obstructive hypertrophic cardiomyopathy (HCM) and biopsy-proven renal AA amyloidosis whose dyspnea and exercise intolerance had worsened over the previous year. Her AA amyloidosis was suspected to be secondary to chronic diverticulitis for which she had undergone hemicolectomy and sigmoidectomy 3 years pri…
  • Myectomy versus alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy. [Journal Article]
    Interact Cardiovasc Thorac Surg. 2020 May 09 [Online ahead of print]Afanasyev AV, Bogachev-Prokophiev AV, … Zheleznev SI
  • CONCLUSIONS: Both procedures improved functional capacity; however, myectomy better-resolved classes III-IV of heart failure. Septal ablation was associated with higher reoperation rates. Myectomy demonstrated benefits in gradient relief and mitral regurgitation elimination. The results suggest that decreasing rates of myectomy procedures need to be investigated and reconsidered.
  • Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy. [Journal Article]
    PLoS One. 2020; 15(5):e0232427.Nijenkamp LLAM, Bollen IAE, … van der Velden J
  • Hypertrophic cardiomyopathy (HCM) is the most frequent genetic cardiac disease with a prevalence of 1:500 to 1:200. While most patients show obstructive HCM and a relatively stable clinical phenotype (stage II), a small group of patients progresses to end-stage HCM (stage IV) within a relatively brief period. Previous research has shown sex-differences in stage II HCM with more diastolic dysfunct…
  • [Hypertrophic cardiomyopathy]. [Review]
    Herz. 2020 May; 45(3):233-242.Batzner A, Seggewiβ H
  • Hypertrophic cardiomyopathy is the most common genetically determined cardiac disease with a prevalence of 0.2-0.6%. The most important pathophysiological phenomenon is dynamic obstruction predominantly of the left ventricular outflow tract in 70% of the patients. Clinical symptoms (e.g. dyspnea, angina pectoris and syncope) are extremely variable depending on changes in preload and afterload and…
  • Combined alcohol septal ablation and transcatheter aortic valve replacement: Drunk and playing with fire. [Editorial]
    Catheter Cardiovasc Interv. 2020 Mar 01; 95(4):838-839.Rowin EJ, Kimmelstiel C
  • Evaluation of the severity of aortic stenosis in the presence of dynamic left ventricular outflow (LVOT) obstruction is challenging. Invasive hemodynamic assessment with provocative maneuvers can be useful to differentiate of the relative components of obstruction. In patients with both dynamic LVOT obstruction and aortic stenosis, surgical myectomy and concurrent surgical aortic valve replacemen…
  • Hypertrophic Cardiomyopathy in "Real-World" Community Cardiology Practice. [Journal Article]
    Am J Cardiol. 2020 May 01; 125(9):1398-1403.Rowin EJ, Maron MS, … Maron BJ
  • Differences in presentation and natural history of hypertrophic cardiomyopathy (HC) between community cardiology practice and referral centers has been a source of considerable uncertainty. We report here a cross-sectional analysis of 253 consecutive HC patients from a "real-world" clinical cardiology setting. When compared with a highly selected referral center cohort, patients in clinical pract…
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