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637 results
  • Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab. [Journal Article]
  • PRPediatr Rheumatol Online J 2019 Jul 08; 17(1):38
  • Signa S, Campione E, … Gattorno M
  • CONCLUSIONS: We describe the association of mutations of the CARD14 gene with an erythrodermic psoriasis pedigree, underlying the necessity to investigate CARD14 mutations in childhood-onset psoriasis cases and confirming the presence of CARD14 causative mutations also in erythrodermic psoriasis form, as recently reported. Also in pediatric age, ustekinumab represents a powerful therapeutic option for this rare condition, that is usually refractory to other treatments. In young children, high and frequent dosages allowed a complete control of the clinical manifestations without any severe side effects, with a long-term follow-up.
  • Interchangeability of radiomic features between [18F]-FDG PET/CT and [18F]-FDG PET/MR. [Journal Article]
  • MPMed Phys 2019; 46(4):1677-1685
  • Vuong D, Tanadini-Lang S, … Bogowicz M
  • CONCLUSIONS: The 4DPETMR showed highest stability for shape, intensity, and texture (>80%) and lower stability for wavelet features (40%). Gradient-based method showed higher stability compared to threshold-based method except from shape features. In PETCT-PETMR, more than 61% of shape and intensity features were stable for both segmentation methods. However, a reduced stability was observed for texture (50%) and wavelet (<30%) features. More wavelet features were robust in the smoothed images (low-pass filtering) compared to images with emphasized heterogeneity (high-pass filtering). Comparing stable features of both investigations, highest agreement was found for intensity and lower agreement for shape, texture, and wavelet features. Only 53.6% of stable texture features in 4DPETMR were also stable in PETCT-PETMR, and even less in case of wavelet features (40.4%). Approximately 16.9% (texture) and 43.2% (wavelet) of stable PETCT-PETMR features are unstable in 4DPETMR. To conclude, shape and intensity features were robust when comparing two types of [18F]-FDG PET scans (PET/CT and PET/MR). Reduced stability was observed for texture and wavelet features. We identified multiple origins of instability of radiomic features, such as attenuation correction differences, different uptake times, and spatial resolution. This needs to be considered when models based on PET/CT are transferred PET/MR models or when combined models are used.
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