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645 results
  • Time-of-flight (TOF) implementation for PET reconstruction in practice. [Journal Article]
    Phys Med Biol 2019Filipovic M, Comtat C, Stute S
  • The time-of-flight (TOF) feature of PET scanners has been used for a long time in PET reconstruction, but many implementational aspects are still incomplete or ambiguous in the literature. Here we formalize and present theoretical and practical implementation details for the reconstruction of clinical TOF histogram and list-mode data using ML-EM. Relevant aspects include the computation of the TO…
  • Brain response to facial expressions in adults with adolescent ADHD. [Journal Article]
    Psychiatry Res Neuroimaging 2019; 292:54-61Lindholm P, Lieslehto J, … Ebeling H
  • CONCLUSIONS: We found differences in brain responses to facial emotional expressions in individuals with previous ADHD compared to control group in a number of brain regions including areas linked to processing of facial emotional expressions and attention. This might indicate that although these individuals no longer fulfill the ADHD diagnosis, they exhibit overactive network properties affecting facial processing.
  • Normal range for MR elastography measured liver stiffness in children without liver disease. [Journal Article]
    J Magn Reson Imaging 2019Sawh MC, Newton KP, … Schwimmer JB
  • CONCLUSIONS: Mean liver stiffness measured with MRE in this cohort was significantly higher than that reported in healthy adults. Despite rigorous screening, some healthy children had stiffness measurements suggestive of liver fibrosis using current published thresholds. Although MRE has the potential to provide noninvasive assessment in patients with suspected hepatic disease, further refinement of this technology will help advance its use as a diagnostic tool for evidence of fibrosis in pediatric populations.
  • Grey matter changes in patients with vestibular migraine. [Journal Article]
    Clin Radiol 2019; 74(11):898.e1-898.e5Wang S, Wang H, … Zhao R
  • CONCLUSIONS: The GM volume of some brain regions of patients with VM is significantly larger than the other two groups. The increased GM volume in these brain regions in patients with VM may be related to self-adaptation of the nervous system, leading to an abnormal brain sensitization. Some of the brain regions with increased GM volume identified in this study were involved in assessment, integration, and expectations of pain and were strongly related to mood and anxiety.
  • Rigid Motion Correction for Brain PET/MR Imaging using Optical Tracking. [Journal Article]
    IEEE Trans Radiat Plasma Med Sci 2019; 3(4):498-503Spangler-Bickell MG, Khalighi MM, … Jansen F
  • A significant challenge during high-resolution PET brain imaging on PET/MR scanners is patient head motion. This challenge is particularly significant for clinical patient populations who struggle to remain motionless in the scanner for long periods of time. Head motion also affects the MR scan data. An optical motion tracking technique, which has already been demonstrated to perform MR motion co…
  • Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab. [Journal Article]
    Pediatr Rheumatol Online J 2019; 17(1):38Signa S, Campione E, … Gattorno M
  • CONCLUSIONS: We describe the association of mutations of the CARD14 gene with an erythrodermic psoriasis pedigree, underlying the necessity to investigate CARD14 mutations in childhood-onset psoriasis cases and confirming the presence of CARD14 causative mutations also in erythrodermic psoriasis form, as recently reported. Also in pediatric age, ustekinumab represents a powerful therapeutic option for this rare condition, that is usually refractory to other treatments. In young children, high and frequent dosages allowed a complete control of the clinical manifestations without any severe side effects, with a long-term follow-up.
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