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10,606 results
  • Oral microbiota and Alzheimer's disease: Do all roads lead to Rome? [Review]
    Pharmacol Res 2019; :104582Sureda A, Daglia M, … Nabavi SM
  • Alzheimer's disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbi…
  • Statin Therapy in Ischemic Stroke Models: A Meta-Analysis. [Review]
    Transl Stroke Res 2019Christophe B, Karatela M, … Connolly ES
  • Statins, drugs known for lipid lowering capabilities and reduction of cardiovascular disease, have demonstrated neuroprotective effects following ischemic stroke in retrospective clinical and animal studies. However, dosing (methods, time, type of statin, and quantity) varies across studies, limiting the clinical applicability of these findings. Furthermore, a comprehensive review of statins in e…
  • Statin-specific inhibition of Rab-GTPase regulates cPKC-mediated IKs internalization. [Journal Article]
    Sci Rep 2019; 9(1):17747Ronzier E, Parks XX, … Lopes CM
  • Statins are prescribed for prevention and treatment of coronary artery disease. Statins have different cholesterol lowering abilities, with rosuvastatin and atorvastatin being the most effective, while statins like simvastatin and fluvastatin having lower effectiveness. Statins, in addition to their cholesterol lowering effects, can prevent isoprenylation of Rab-GTPase proteins, a protein family …
  • Double trouble: ciclosporin-simvastatin coinduced rhabdomyolysis. [Journal Article]
    BMJ Case Rep 2019; 12(11)Hafouda Y, Sharma A, … Yesudian PD
  • A 73-year-old woman presented with an acute exacerbation of her long-standing psoriasis. Ciclosporin was commenced due to the severity of her symptoms resulting in remission within 2 weeks. Full blood count, urea and electrolytes following initiation of treatment were unremarkable, although she complained of muscle aches, which was attributed to her known multiple sclerosis. Three weeks later she…
  • Targeted Drug Delivery from Titanium Implants: A Review of Challenges and Approaches. [Journal Article]
    Adv Exp Med Biol 2019Barik A, Chakravorty N
  • Titanium implants are considered the gold standard of treatment for dental and orthopedic applications. Biocompatibility, low elasticity, and corrosion resistance are some of the key properties of these metallic implants. Nonetheless, a long-term clinical failure of implants may occur due to inadequate osseointegration. Poor osseointegration induces mobility, inflammation, increased bone resorpti…
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