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(skeletal muscle relaxants)
84,550 results
  • [Pharmacological Treatment of Malignant Hyperthermia: Update 2019]. [Journal Article]
    Anasthesiol Intensivmed Notfallmed Schmerzther 2019; 54(9):549-558Schuster F, Johannsen S
  • Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle presenting as a hypermetabolic response to potent volatile anesthetics such as sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxant succinylcholine. Following introduction of the hydantoin derivative dantrolene, the previously high mortality of fulminant MH episodes could be reduced from > 80% to less…
  • Preliminary Analysis of Factors Associated with Blood Loss in Neuromuscular Scoliosis Surgery. [Journal Article]
    Bull Hosp Jt Dis (2013) 2018; 76(3):207-215Toombs C, Verma K, … Errico T
  • CONCLUSIONS: Patients with NMS remain a challenging group of patients to treat. We find that age, operative time, and postoperative platelets are predictive of increased blood loss while only age was related to greater transfused units. Our findings may predict the need for blood products and antifibrinolytic agents preoperatively in this heterogeneous population, especially as patients age.
  • Immunosuppressive and Immunomodulatory Therapies for Neuromuscular Diseases Part I: Traditional Agents. [Review]
    Muscle Nerve 2019Farmakidis C, Dimachkie M, … Barohn RJ
  • Immunosuppressive and immunomodulatory therapies have had a major effect on the treatment of immune-mediated neuromuscular diseases. Following the landmark introduction of synthetic corticosteroids, other therapies have become available including plasma exchange (PLEX), immunoglobulin G (IgG), and steroid-sparing immunosuppressive drugs. More recently, novel biologically derived and antigen-speci…
  • Current Status of Continuous Electroencephalographic Monitoring in Critically Ill Children. [Review]
    Pediatr Neurol 2019Bozarth XL, McGuire J, Novotny E
  • The utilization of continuous electroencephalographic monitoring in critical care units has increased significantly, and several consensus statements and guidelines have been published. The use of critical care electroencephalographic monitoring has become a standard of care in many centers in the United States and other countries. The most common indication is to detect electrographic seizures a…
  • Antiviral treatment for Bell's palsy (idiopathic facial paralysis). [Review]
    Cochrane Database Syst Rev 2019; 9:CD001869Gagyor I, Madhok VB, … Sullivan F
  • CONCLUSIONS: The combination of antivirals and corticosteroids may have little or no effect on rates of incomplete recovery in comparison to corticosteroids alone in Bell's palsy of various degrees of severity, or in people with severe Bell's palsy, but the results were very imprecise. Corticosteroids alone were probably more effective than antivirals alone and antivirals plus corticosteroids were more effective than placebo or no treatment. There was no clear benefit from antivirals alone over placebo.The combination of antivirals and corticosteroids probably reduced the late sequelae of Bell's palsy compared with corticosteroids alone. Studies also showed fewer episodes of long-term sequelae in corticosteroid-treated participants than antiviral-treated participants.We found no clear difference in adverse events from the use of antivirals compared with either placebo or corticosteroids, but the evidence is too uncertain for us to draw conclusions.An adequately powered RCT in people with Bell's palsy that compares different antiviral agents may be indicated.
  • Bispectral Index for Titrating Sedation in ARDS Patients During Neuromuscular Blockade. [Journal Article]
    Am J Crit Care 2019; 28(5):377-384Bass S, Vance ML, … Duggal A
  • CONCLUSIONS: Titration based on bispectral index did not result in a significant difference in sedation or analgesia exposure, or clinical outcomes, from that achieved with traditional sedation monitoring in patients with ARDS who were receiving a neuromuscular blocking agent, despite more dose adjustments during the first 24 hours of receiving the neuromuscular blocking agent.
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