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Unbound Medicine.
(skeletal muscle relaxants)
85,886 results
  • Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety. [Review]
    Drug Saf. 2020 Jul 01 [Online ahead of print]Edwards AB, Mastaglia FL, … Meloni BP
  • Cationic arginine-rich peptides represent a novel class of peptides being developed as neuroprotective agents for stroke and other acute and chronic neurological disorders. As a group, cationic arginine-rich peptides have a diverse range of other biological properties including the ability to traverse cell membranes, modulate immune responses, antagonise ion channel receptor function, as well as …
  • Sugammadex: routine use vs restrictive use. [Journal Article]
    Br J Hosp Med (Lond). 2020 Jun 02; 81(6):1-2.Ashiru G, Carrington M
  • Worldwide, the use of sugammadex for the reversal of neuromuscular blocking agents worldwide is restricted. This article reflects on how more liberal use of sugammadex might alter patient experience, anaesthetic delivery and surgical techniques.
  • Assessment of Physician Prescribing of Muscle Relaxants in the United States, 2005-2016. [Journal Article]
    JAMA Netw Open. 2020 Jun 01; 3(6):e207664.Soprano SE, Hennessy S, … Leonard CE
  • CONCLUSIONS: This study found that SMR use increased rapidly between 2005 and 2016, which is a concern given the prominent adverse effects and limited long-term efficacy data associated with their use. These findings suggest that approaches are needed to limit the long-term use of SMRs, especially in older adults, similar to approaches to limit long-term use of opioids and benzodiazepines.
  • Sodium channel myotonia may be associated with high-risk brief resolved unexplained events. [Case Reports]
    Wellcome Open Res. 2020; 5:57.Cea G, Andreu D, … Matthews E
  • Brief resolved unexplained events (BRUEs) have numerous and varied causes posing a challenge to investigation and management. A subset of infants with the neuromuscular disorder sodium channel myotonia, due to mutations in the SCN4A gene, experience apnoeic events due to laryngospasm (myotonia) of the upper airway muscles that may present as a BRUE. We sought to ascertain the frequency, severity …
  • Supraglottic Airway Use for Transfemoral-Transcatheter Aortic Valve Replacement. [Journal Article]
    J Cardiothorac Vasc Anesth. 2020 May 15 [Online ahead of print]Azad SS, Cobey FC, … Shapeton AD
  • CONCLUSIONS: Supraglottic airway management in transcatheter aortic valve replacement was feasible without an increase in major adverse cardiovascular outcomes compared with endotracheal tube management during general anesthesia. Supraglottic airway patients trended toward receiving fewer opioids and received significantly fewer neuromuscular blockers while also having significantly shorter time under general anesthesia and total time in the operating room.
  • Neuromuscular blockade management in the critically Ill patient. [Review]
    J Intensive Care. 2020; 8:37.Renew JR, Ratzlaff R, … Prielipp RC
  • Neuromuscular blocking agents (NMBAs) can be an effective modality to address challenges that arise daily in the intensive care unit (ICU). These medications are often used to optimize mechanical ventilation, facilitate endotracheal intubation, stop overt shivering during therapeutic hypothermia following cardiac arrest, and may have a role in the management of life-threatening conditions such as…
  • Sugammadex: A Limited But Important Role in Emergency Medicine. [Journal Article]
    Pediatr Emerg Care. 2020 Jun; 36(6):296-301.Chen B
  • Sugammadex reverses neuromuscular blockade by the steroidal nondepolarizing neuromuscular blocking agents rocuronium and vecuronium. In 2015, it was approved in the United States by the Food and Drug Administration for adult use. However, there are ongoing clinical trials investigating its use in the pediatric population. Before approval in adult use in the United States, several adverse effects …
  • Gastroparesis: New insights into an old disease. [Review]
    World J Gastroenterol. 2020 May 21; 26(19):2333-2348.Usai-Satta P, Bellini M, … Bassotti G
  • Gastroparesis (Gp) is a chronic disease characterized by a delayed gastric emptying in the absence of mechanical obstruction. Although this condition has been reported in the literature since the mid-1900s, only recently has there been renewed clinical and scientific interest in this disease, which has a potentially great impact on the quality of life. The aim of this review is to explore the pat…
  • Anaphylaxis in pregnancy: a population-based multinational European study. [Journal Article]
    Anaesthesia. 2020 May 28 [Online ahead of print]McCall SJ, Bonnet MP, … INOSS collaboration
  • Anaphylaxis in pregnancy is a rare but severe complication for both mother and infant. Population-based data on anaphylaxis in pregnancy are lacking from mainland European countries. This multinational study presents the incidence, causative agents, management and maternal and infant outcomes of anaphylaxis in pregnancy. This descriptive multinational study used a combination of retrospective (Fi…
  • Muscle-Specific Kinase Myasthenia Gravis. [Review]
    Front Immunol. 2020; 11:707.Borges LS, Richman DP
  • Thirty to fifty percent of patients with acetylcholine receptor (AChR) antibody (Ab)-negative myasthenia gravis (MG) have Abs to muscle specific kinase (MuSK) and are referred to as having MuSK-MG. MuSK is a 100 kD single-pass post-synaptic transmembrane receptor tyrosine kinase crucial to the development and maintenance of the neuromuscular junction. The Abs in MuSK-MG are predominantly of the I…
  • Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination. [Journal Article]
    Mar Drugs. 2020 May 14; 18(5)Mansbach RA, Chakraborty S, … Gnanakaran S
  • Conotoxins are short, cysteine-rich peptides of great interest as novel therapeutic leads and of great concern as lethal biological agents due to their high affinity and specificity for various receptors involved in neuromuscular transmission. Currently, of the approximately 6000 known conotoxin sequences, only about 3% have associated structural characterization, which leads to a bottleneck in r…
  • The effects of acetylcholinesterase inhibitors on morbidity after general anesthesia and surgery. [Review]
    Neuropharmacology. 2020 Aug 15; 173:108134.Shaydenfish D, Wongtangman K, … Schaefer MS
  • Non-depolarizing neuromuscular blocking agents are used during general anesthesia to facilitate intubation and optimize surgical conditions. When patients leave the operating room after surgery, postoperative residual neuromuscular block occurs frequently, increasing vulnerability to respiratory complications such as hypoxemia and unplanned postoperative mechanical ventilation. To restore neuromu…
  • Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water. [Journal Article]
    Angew Chem Int Ed Engl. 2020 May 15 [Online ahead of print]Xue W, Zavalij PY, Isaacs L
  • We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imag…
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