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786,076 results
  • The Role of Obesity in Pediatric Orthopedics. [Journal Article]
  • JAJ Am Acad Orthop Surg Glob Res Rev 2019; 3(5):e036
  • Nowicki P, Kemppainen J, … Cassidy J
  • Pediatric obesity has become a worldwide epidemic and leads to notable effects on the developing skeleton that can have lifelong implications. Obesity in the pediatric population alters bone metaboli…
  • Tubulin in Platelets: When the Shape Matters. [Review]
  • IJInt J Mol Sci 2019 Jul 16; 20(14)
  • Cuenca-Zamora EJ, Ferrer-Marín F, … Teruel-Montoya R
  • Platelets are anuclear cells with a short lifespan that play an essential role in many pathophysiological processes, including haemostasis, inflammation, infection, vascular integrity, and metastasis…
  • Stickler syndrome: exploring prophylaxis for retinal detachment. [Journal Article]
  • COCurr Opin Ophthalmol 2019 Jul 10
  • Coussa RG, Sears J, Traboulsi EI
  • CONCLUSIONS: Stickler syndrome is a systemic collagenopathy affecting multiple organ systems including the eye, ear, and skeleton. Stickler syndrome is probably the most common cause of genetically determined pediatric rhegmatogenous retinal detachment. Congenital developmental anomalies constitute over half rhegmatogenous detachments (RRD) in patients less than 10 years. The majority are caused by hereditary vitreoretinopathies associated with Stickler syndrome. Sixty percent of patients with Stickler syndrome develop RRD's over their lifetime with possible severe visual loss and subsequent lifelong morbidity. In view of these complications, some have emphasized the importance of prophylactic laser treatment to the retina of patients with Stickler syndrome to reduce the occurrence of and/or prevent future rhegmatogenous retinal detachment, but there appears to be insufficient data to support the absolute benefit of such prophylactic treatment. Guidelines regarding the age at prophylactic treatment as well as type and frequency of intervention are scarce and would benefit from additional clinical investigations.
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