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(sleep maintenance)
15,534 results
  • Tristetraprolin targets Nos2 expression in the colonic epithelium. [Journal Article]
    Sci Rep 2019; 9(1):14413Eshelman MA, Matthews SM, … Yochum GS
  • Tristetraprolin (TTP), encoded by the Zfp36 gene, is a zinc-finger protein that regulates RNA stability primarily through association with 3' untranslated regions (3' UTRs) of target mRNAs. While TTP is expressed abundantly in the intestines, its function in intestinal epithelial cells (IECs) is unknown. Here we used a cre-lox system to remove Zfp36 in the mouse epithelium to uncover a role for T…
  • The protective effect of edaravone on memory impairment induced by chronic sleep deprivation. [Journal Article]
    Psychiatry Res 2019; 281:112577Alzoubi KH, Al Mosabih HS, Mahasneh AF
  • Sleep plays a critical role in body health maintenance, whereas sleep deprivation (SD) negatively affects cognitive function. Cognitive defects mainly memory impairment resulting from sleep deprivation were related to an increase in the level of oxidative stress in the body, including the brain hippocampus region. Edaravone is a potent free radical scavenger having antioxidant effect. In the curr…
  • Estradiol treatment improves biological rhythms in a preclinical rat model of menopause. [Journal Article]
    Neurobiol Aging 2019; 83:1-10Yin W, Borniger JC, … Gore AC
  • The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when estradiol (E) treatment should commence and for how long are key clinical quest…
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