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23,509 results
  • Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. [Review]
    Life Sci 2019; :116776Yaribeygi H, Sathyapalan T, Sahebkar A
  • Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 enzyme metabolizes glucagon-like peptide-1 and various dipeptidyl peptidase-4 enzyme inhibitors (DPP-4i) are also used in the management of diabetes. These antidiabetic agents provide anti-hyperglycemic effects via severa…
  • Spatiotemporal control of mitotic exit during anaphase by an Aurora B-Cdk1 crosstalk. [Journal Article]
    Elife 2019; 8Afonso O, Castellani CM, … Maiato H
  • According to the prevailing 'clock' model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However, mitotic exit was recently shown to be a function of chromosome separation during anaphase, assisted by a midzone Aurora B phosphorylation gradi…
  • A role for hippocampal adult neurogenesis in shifting attention toward novel stimuli. [Journal Article]
    Behav Brain Res 2019; :112152Weeden CSS, Mercurio JC, Cameron HA
  • New granule neurons are added to the dentate gyrus region of the hippocampus throughout life. Behavioral effects of slowing or stopping this ongoing neurogenesis are generally observed only in complex cognitive tasks involving high levels of cue or memory interference or in emotional tasks presented after stress exposure. We tested the role of new neurons in a one-trial task in naïve rats, a simp…
  • Hybrid foraging search in younger and older age. [Journal Article]
    Psychol Aging 2019Wiegand I, Seidel C, Wolfe J
  • In hybrid foraging tasks, observers search visual displays, so called patches, for multiple instances of any of several types of targets with the goal of collecting targets as quickly as possible. Here, targets were photorealistic objects. Younger and older adults collected targets by mouse clicks. They could move to the next patch whenever they decided to do so. The number of targets held in mem…
  • Understanding the Frontiers of Human Longevity in India: Imperative and Palliative Care. [Journal Article]
    Indian J Palliat Care 2019 Jul-Sep; 25(3):455-461Kumar Y
  • This article provides a theoretical and empirical insight on the study of population aging in India, with the special reference to the causes that have made it extremely significant. It evidently looks into the factors that are extensively associated with the process of population aging and have contributed to the Indian society. Demographically speaking, in the Indian context, the process of dem…
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