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1,344 results
  • A pilot study of pembrolizumab in smoldering myeloma: report of the clinical, immune, and genomic analysis. [Journal Article]
    Blood Adv 2019; 3(15):2400-2408Manasanch EE, Han G, … Orlowski RZ
  • Multiple myeloma is, in most patients, an incurable cancer. Its precursors can be identified with routine tests setting the stage for early intervention to prevent active myeloma. We investigated the efficacy and safety of pembrolizumab, an antiprogrammed cell death 1 antibody, in smoldering myeloma patients with intermediate/high risk of progression to symptomatic myeloma. Thirteen patients were…
  • Haemorrhagic bullous lesions indicating cutaneous light chain amyloidosis with smoldering myeloma. [Journal Article]
    J Eur Acad Dermatol Venereol 2019Gambichler T, Doerler M, … Susok L
  • Systemic amyloidoses (SAL) and multiple myeloma (MM) are intimately connected through their cell of origin (plasma cells). Immunoglobulin light chain amyloidosis (AL) is the most frequent form of SAL characterized by cutaneous manifestations including petechia and haemorraghes such as Racoon-sign (periorbital bruising), and macroglossia.1,2 Here we report an unusual case of cutaneous amyloidosis …
  • Novel approaches to treating advanced systemic mastocytosis. [Review]
    Clin Pharmacol 2019; 11:77-92Gilreath JA, Tchertanov L, Deininger MW
  • Mastocytosis is a myeloproliferative neoplasm characterized by expansion of abnormal mast cells (MCs) in various tissues, including skin, bone marrow, gastrointestinal tract, liver, spleen, or lymph nodes. Subtypes include indolent systemic mastocytosis, smoldering systemic mastocytosis and advanced systemic mastocytosis (AdvSM), a term collectively used for the three most aggressive forms of the…
  • A review on the sustainability of thermal treatment for contaminated soils. [Review]
    Environ Pollut 2019; 253:449-463Ding D, Song X, … LaChance J
  • Sustainable remediation is a goal in the remediation industry. Thermal treatment can remediate contaminated sites quickly and reliably, but its energy-intensive nature and potential to damage soil properties make it seemingly not sustainable. This review evaluates the potential for thermal treatment to become a sustainable remediation technology based on a comprehensive analysis of the scientific…
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