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519,002 results
  • Nerve Excitability Differences in Slow and Fast Motor Axons of the Rat: more than just Ih. [Journal Article]
    J Neurophysiol 2019Bell JM, Lorenz C, Jones KE
  • Objective: To determine biophysical differences between fast and slow motor axons using threshold tracking and demonstrate confounds related to anaesthetic. Methodology: Nerve excitability of motor axons innervating the slow-twitch soleus (SOL) and fast-twitch tibialis anterior (TA) muscles was tested. The experiments were conducted with sodium pentobarbital (SP) anaesthetic and compared to previ…
  • A Case of Atypical Adult Presentation of Urea Cycle Disorder. [Case Reports]
    WMJ 2019; 118(2):98-100Wang B, Jha P
  • CONCLUSIONS: Although many cases of urea cycle disorder present in neonates 24 to 48 hours following birth, a delayed presentation may be observed in female carriers with partial activity of any urea cycle enzyme leading to ammonia buildup. This is the result of stress-related events that form a catabolic state involving protein breakdown within the body that trigger increased ammonia levels.A diagnosis of urea cycle disorder should be suspected in patients who have had a recent stressor with progressive lethargy and confusion associated with hyperammonemia, so that treatment may begin with intravenous sodium benzoate and phenylacetate initially and hemodialysis at 8 hours if ammonia levels do not decrease to avoid permanent neurologic damage.
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