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268,879 results
  • Mechanics and drug release from poroviscoelastic hydrogels: experiments and modeling. [Journal Article]
    Eur J Pharm Biopharm. 2020 May 26 [Online ahead of print]Caccavo D, Lamberti G, Angela Barba A
  • Hydrogels are peculiar soft materials formed by a 3D polymeric network surrounded by water molecules. In these systems the mechanical and the chemical energy are well balanced and an applied external stimulus (mechanical or chemical) can cause a distinctive response, where the contributions of the mechanics and the mass transport are combined to form a "poroviscoelastic" behavior. In this work th…
  • Cellular fate of deformable needle-shaped PLGA-PEG fibers. [Journal Article]
    Acta Biomater. 2020 May 26 [Online ahead of print]Zhang B, Zhu M, … Li Q
  • Deformability of micro/nanometer sized particles plays an important role in particle-cell interactions and thus becomes a key parameter in carrier design in biomedicine application such as drug delivery and vaccinology. Yet the influence of material's deformability on the cellular fate of the particles as well as physiology response of live cells are to be understood. Here we show the cellular fa…
  • Extracellular vesicle cross-talk in the liposarcoma microenvironment. [Journal Article]
    Cancer Lett. 2020 May 26 [Online ahead of print]Casadei L, Pollock RE
  • Liposarcoma (LPS) is the most prevalent soft tissue sarcoma; among the four different LPS subtypes, dedifferentiated liposarcoma (DDLPS) is especially worrisome given its propensity for local and distant recurrence, with an overall survival rate of only 10% at 10 years. Our understanding of the molecular drivers of this disease is rudimentary at best; knowledge about how DDLPS interacts with cell…
  • Collagen peptide simulated bending after applied axial deformation. [Journal Article]
    J Mech Behav Biomed Mater. 2020 Aug; 108:103835.Bourne JW, Shi L, Torzilli PA
  • Structural proteins in the extracellular matrix are subjected to a range of mechanical loading conditions, including varied directions of force application. Molecular modeling suggests that these mechanical forces directly affect collagen's conformation and the subsequent mechanical response at the molecular level is complex. For example, tensile forces in the axial direction result in collagen t…
  • Mechanical behaviour of additively manufactured bioactive glass/high density polyethylene composites. [Journal Article]
    J Mech Behav Biomed Mater. 2020 Aug; 108:103830.Jeyachandran P, Bontha S, … Doddamani M
  • Bioactive glass (BAG) is a well-known biomaterial that can form a strong bond with hard and soft tissues and can also aid in bone regeneration. In this study, BAG is added to a polymer to induce bioactivity and to realize fused filament fabrication (FFF) based printing of polymer composites for potential orthopaedic implant applications. BAG (5, 10, and 20 wt%) is melt compounded with high densit…
  • US-guided Localization and Removal of Soft-Tissue Foreign Bodies. [Journal Article]
    Radiographics. 2020 May 29 [Online ahead of print]Del Cura JL, Aza I, … Korta I
  • US-guided foreign body removal is a nonsurgical highly effective technique used to manage symptomatic foreign bodies and should be considered as a first-line treatment procedure. The authors describe a technique used for US detection and US-guided removal of various types of foreign bodies and discuss the efficacy of the procedure. Soft-tissue foreign bodies can result from accidents or medical p…
  • Stable Lithium Metal Anode Enabled by 3D Soft Host. [Journal Article]
    ACS Appl Mater Interfaces. 2020 May 29 [Online ahead of print]Wang H, Wu J, … Huang Y
  • Lithium (Li) metal is among the most promising anode materials for next-generation rechargeable batteries. However, inevitable Li dendrite growth and huge volume expansion severely restrict its practical application. Here, we propose a melamine sponge@silver nanowires (MS@AgNWs) current collector to achieve highly reversible Li storage. By combining the strength advantages of lithophilic nano-see…
  • Flow fields control nanostructural organization in semiflexible networks. [Journal Article]
    Soft Matter. 2020 May 29 [Online ahead of print]Rosén T, Mittal N, … Söderberg LD
  • Hydrodynamic alignment of proteinaceous or polymeric nanofibrillar building blocks can be utilized for subsequent assembly into intricate three-dimensional macrostructures. The non-equilibrium structure of flowing nanofibrils relies on a complex balance between the imposed flow-field, colloidal interactions and Brownian motion. The understanding of the impact of non-equilibrium dynamics is not on…
  • Poroelastic properties of hydrogel microparticles. [Journal Article]
    Soft Matter. 2020 May 29 [Online ahead of print]Berry JD, Biviano M, Dagastine RR
  • Hydrogels can be formed in a number of different geometries depending upon desired function. However, due to the lack of appropriate models required to interpret experimental data, it remains unclear whether hydrogel microparticles have the same poroelastic properties as hydrogel films made with the same components. We perform numerical simulations to determine the universal force relaxation of a…
  • Diffusion properties of self-propelled particles in cellular flows. [Journal Article]
    Soft Matter. 2020 May 29 [Online ahead of print]Caprini L, Cecconi F, … Sarracino A
  • We study the dynamics of a self-propelled particle advected by a steady laminar flow. The persistent motion of the self-propelled particle is described by an active Ornstein-Uhlenbeck process. We focus on the diffusivity properties of the particle as a function of persistence time and free-diffusion coefficient, revealing non-monotonic behaviors, with the occurrence of a minimum and a steep growt…
  • Switchable adhesion of soft composites induced by a magnetic field. [Journal Article]
    Soft Matter. 2020 May 29 [Online ahead of print]Testa P, Chappuis B, … Dufresne ER
  • Switchable adhesives have the potential to improve the manufacturing and recycling of parts, and to enable new modes of motility for soft robots. Here, we demonstrate magnetically-switchable adhesion of a two-phase composite to non-magnetic objects. The composite's continuous phase is a silicone elastomer, and the dispersed phase is a magneto-rheological fluid. The composite is simple to prepare,…
  • Dynamic dissipative solitons in nematics with positive anisotropies. [Journal Article]
    Soft Matter. 2020 May 29 [Online ahead of print]Shen Y, Dierking I
  • Electric field induced instabilities of nematic molecules are of importance for both fundamental science and practical applications. Complex electro-hydrodynamic (EHD) effects such as electro-convection, fingerprint textures, spatiotemporal chaos, and solitons in nematics have been broadly investigated and generated much attention. In this work, dissipative solitons as a novel EHD phenomenon are …
  • Rates of transesterification in epoxy-thiol vitrimers. [Journal Article]
    Soft Matter. 2020 May 29 [Online ahead of print]Gablier A, Saed MO, Terentjev EM
  • Vitrimers, an important subset of dynamically crosslinked polymer networks, have many technological applications for their excellent properties, and the ability to be re-processed through plastic flow above the so-called vitrification temperature. We report a simple and efficient method of generating such adaptive crosslinked networks relying on transesterification for their bond exchange by util…
  • Membrane Engineering: Phase Separation in Polymeric Giant Vesicles. [Journal Article]
    Small. 2020 May 28 [Online ahead of print]Rideau E, Wurm FR, Landfester K
  • Cell membranes exhibit elaborate lipidic patterning to carry out a myriad of functions such as signaling and trafficking. Domain formation in giant unilamellar vesicles (GUVs) is thus of interest for understanding fundamental biological processes and to provide new prospects for biocompatible soft materials. Lipid rearrangements in lipidic GUVs and lipid/polymer GUVs are extensively studied where…
  • Extended endocrine therapy in premenopausal breast cancer patients: Where are we now? [Journal Article]
    Breast J. 2020 May 29 [Online ahead of print]Villasco A, D'Alonzo M
  • Approximately 25% of new breast cancers are diagnosed in premenopausal patients, 50%-70% presenting as estrogen receptor-positive (ER+) breast tumors. Five-year adjuvant endocrine therapy (ET) with Tamoxifen is the cornerstone treatment for those patients but the evidence that up to 50% of ER + breast cancer distant recurrences develop after this time has now raised some questions. ATLAS and aTTo…
  • Keystone flap: a safe coverage option in the handling of salvage for myelomeningocele. [Journal Article]
    Childs Nerv Syst. 2020 May 28 [Online ahead of print]Gómez O, Barrera C
  • CONCLUSIONS: The use of keystone flaps is a useful, accessible, and versatile technique as a management option for lumbosacral coverage defects in MMC, achieving a stable and safe covering of the meninges, without cerebrum-spinal fluid fistulas, which also allows the primary closure of the soft tissues in the donor area. The safety of this type of flap when used as salvage in lumbosacral defects with previously handled and raised tissues could infer that it is reliable enough to be considered as a first surgical option in the initial management of MMC.
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