- Clinical utility of a postprocedural CT scan in CT-guided musculoskeletal biopsies. [Journal Article]
- SRSkeletal Radiol 2019 Jul 20
- CONCLUSIONS: Immediate postprocedural complications in CT-guided musculoskeletal interventions are rare. When complications do occur, they are usually minor. To substantially reduce radiation dose, postinterventional CT scans should not be performed routinely.
- Rhinophore bio-inspired stretchable and programmable electrochemical sensor. [Journal Article]
- BBBiosens Bioelectron 2019 Jul 16; 142:111519
- Rhinophore, a bio-chemical sensory organ with soft and stretchable/retractable features in many marine molluscs species, exhibits tunable chemosensory abilities in terms of far/near-field chemical de…
Rhinophore, a bio-chemical sensory organ with soft and stretchable/retractable features in many marine molluscs species, exhibits tunable chemosensory abilities in terms of far/near-field chemical detection and molecules' source orientation. However, existing artificial bio-chemical sensors cannot provide tunable modality sensing. Inspired by the anatomical units (folded sensory epithelium) and the functions of a rhinophore, this work introduces a stretchable electrochemical sensor that offers a programmable electro-catalytic performance towards glucose based on the fold/unfold regulation of the gold nanomembrane on an elastic fiber. Geometrical design rationale and covalent bonding strategy are used to realize the robust mechanical and electrical stability of this stretchable bionic sensor. Electrochemical tests demonstrated that the sensitivities of the as-prepared bionic sensor exhibit a linear relationship with its strain states from 0% to 150%. Bio-inspired sensory functions are tested by regulating the strain of the bionic sensor. The sensor achieves a sensitivity of 195.4 μA mM-1 in a low glucose concentration range of 8-206 μM at 150% strain for potentially far-field chemical detection, and a sensitivity of 14.2 μA mM-1 in a high concentration range of 10-100 mM at 0% strain for near-field chemical detection. Moreover, the bionic sensor performs the detection while extending its length can largely enhance the response signal, which is used to distinguish the molecules' source direction. This proposed bionic sensor can be useful in wearable devices, robotics and bionics applications which require diverse modality sensing and smart chemical tracking system.
- Determining and unravelling origins of reduced photoinactivation efficacy of bacteria in milk. [Journal Article]
- JPJ Photochem Photobiol B 2019 Jul 12; 197:111554
- Bovine mastitis is an endemic disease of dairy cattle that is considered to be one of the most frequent and costly diseases in veterinary medicine. An increase in the incidence of disease results in …
Bovine mastitis is an endemic disease of dairy cattle that is considered to be one of the most frequent and costly diseases in veterinary medicine. An increase in the incidence of disease results in the increased use of antibiotics, which in turn increases the potential of bacterial resistance. This study aimed to investigate the effectiveness of antimicrobial photodynamic therapy (aPDT) in the treatment of bovine mastitis, as an alternative to systemic antibiotics. To identify the key factors affecting photoinactivation efficacy, realistic experiments in view of the end-use were conducted in milk samples using two different photosensitizers: methylene blue (MB) and silicon (IV) phthalocyanine derivative (SiPc). We explored the effects of divalent ions and fat content on the aPDT outcome and determined influence of different proteins on aPDT efficacy. Levels of bacterial sensitivity to PSs varied depending on the type of bacteria (Gram-positive vs. Gram-negative) and light exposure time. Critical interrelated factors affecting aPDT in milk were identified and an efficient combination of treatment conditions that can lead to a full photodynamic inactivation of bacteria was determined.
- Incorporating functional traits to enhance multimetric index performance and assess land use gradients. [Journal Article]
- STSci Total Environ 2019 Jul 04; 691:1005-1015
- Taxonomic-based multimetric indices (MMIs) have been widely employed for assessing ecosystem status, particularly through the use of stream macroinvertebrate assemblages. However, the functional dive…
Taxonomic-based multimetric indices (MMIs) have been widely employed for assessing ecosystem status, particularly through the use of stream macroinvertebrate assemblages. However, the functional diversity and composition of assemblages is also important for maintaining stream ecosystem condition. Nonetheless, aquatic insect functional diversity and composition have not commonly been included in MMIs. Our goal was to advance our understanding of the performance and ecological interpretation of an MMI that potentially combined functional and taxonomic metrics. We sampled aquatic insects and natural and land-use variables at 74 temperate Chinese streams. We selected a candidate set of 36 functional and 20 taxonomic metrics that were screened by range tests, natural variation, responsiveness to anthropogenic disturbance, and redundancy for subsequent inclusion in MMIs. We determined if natural variation adjustments improved the performance of a functional-taxonomic MMI. Finally, we evaluated the degree to which the functional-taxonomic MMI served as an early-warning indicator of land use intensity. Natural variation explained between 19.62% and 71.02% of metric variability, indicating that functional metrics changed systematically along natural gradients. The final functional-taxonomic MMI adjusted for natural variation incorporated multiple aspects of assemblage characteristics: functional richness, Rao's quadratic entropy, abundance-weighted frequency of soft bodies, abundance-weighted frequency of predators, and number of Diptera taxa. In contrast to the natural variation unadjusted MMI, the functional-taxonomic adjusted MMI clearly distinguished least-disturbed sites from most-disturbed sites, exhibited high precision and low bias, and showed a significant negative response to land uses. The slope of a linear regression relative to 0-10% urban and 0-20% agriculture was significantly steeper for the functional-taxonomic adjusted MMI than that of the taxonomic adjusted MMI. We conclude that functional-taxonomic adjusted MMIs are more effective indicators of ecological condition and risks to biota from human pressures than are purely taxonomic unadjusted MMIs because functional-taxonomic MMIs are more sensitive to subtle anthropogenic pressures.
- Development and characterization of a biomimetic coating for percutaneous devices. [Journal Article]
- CSColloids Surf B Biointerfaces 2019 Jul 08; 182:110351
- Percutaneous osseointegrated prosthetics (POP), which consist of a metallic post attached to the bone that extends outward through the skin to connect to an external prosthesis, have become a clinica…
Percutaneous osseointegrated prosthetics (POP), which consist of a metallic post attached to the bone that extends outward through the skin to connect to an external prosthesis, have become a clinically relevant option to replace the typical socket-residual limb connection. POP devices offer several advantages such as mechanical off-loading of soft tissues, direct force transfer to the musculoskeletal system, greater proprioception, and overall improvement in limb kinesis compared to a socket system. However, POP devices create several challenges including epidermal downgrowth, increased infection risk, and mechanical tearing at the skin-implant interface. To address these issues, biomimetic surfaces and coatings have been developed in an attempt to create an infection-free and cohesive interface between POP devices and skin. The fingernail is a prime example of a natural system with a skin interface that is both mechanically and biologically stable. Exploiting keratins' previously demonstrated tissue compatibility and creating a biomimetic coating for POP devices that can imitate the human fingernail, and demonstrating its ability to promote a stable interface with skin tissue is the goal of this work. Silane coupling aided in producing a coating on titanium substrates consisting of human keratin proteins. Several combinations of silane and keratin derivatives were investigated, and in general showed a nano-scale coating thickness that supported skin cell (i.e. fibroblast and keratinocyte) adhesion. Initial enzyme-mediated degradation resistance was also demonstrated, but the coatings appeared to degrade at long time periods. Importantly, keratinocytes showed a stable phenotype with no indication of wound healing-like activity. These data provide justification to further explore keratin biomaterials for POP coatings that may stabilize the implant-skin interface.
- Fluorescent indocyanine green angiography: preliminary results in microsurgery monitoring. [Journal Article]
- JSJ Stomatol Oral Maxillofac Surg 2019 Jul 18
- CONCLUSIONS: Evaluation of microvascular flap perfusion is still based on subjective clinical features. Clinical monitoring is observer-dependent and does not allow information sharing, test reproducibility, and consistent postoperative follow-up. The successful of salvage rate is linked to the delay between the onset of ischemia and its clinical assessment. FA ICG could be a reliable method for monitoring free-tissue transfers. This technique is objective, non invasive and facilitate a complex reconstructive procedure to augment is liability. This technique may be used such a pedagogical tool for young practitioners in their first microsurgery procedures.
- Does Recession of the Posterior Cruciate Ligament Influence Outcome in Total Knee Arthroplasty? [Journal Article]
- JAJ Arthroplasty 2019 Jun 05
- CONCLUSIONS: This study presents evidence of similar clinical outcomes when the PCL is retained or released during PCL-retaining TKA, provided attention is paid to appropriate soft tissue balancing. CR TKA undergoing partial or complete release of the PCL should not routinely be converted to a posterior-stabilized knee design.
- Development and validation of a new intraocular pressure estimate for patients with soft corneas. [Journal Article]
- JCJ Cataract Refract Surg 2019 Jul 17
- CONCLUSIONS: The bIOPs algorithm was more reliable at estimating the IOP in eyes with a soft cornea and was validated for use in eyes with keratoconus.
- Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification. [Journal Article]
- PRPathol Res Pract 2019 Jul 13; :152535
- Inflammatory myofibroblastic tumor (IMT) is a neoplastic proliferation of myofibroblastic/fibroblastic cells with a variable admixture of inflammatory cells. It primarily affects soft tissue and visc…
Inflammatory myofibroblastic tumor (IMT) is a neoplastic proliferation of myofibroblastic/fibroblastic cells with a variable admixture of inflammatory cells. It primarily affects soft tissue and viscera of children and young adults. IMT occurring in bone is extremely rare. Approximately 50% of IMTs carry a clonal rearrangement of the anaplastic lymphoma kinase (ALK) gene, while other receptor tyrosine kinase gene rearrangements have been seen in a small subset of IMT. Herein, we report the first case of IMT which harbors an ALK gene amplification rather than a rearrangement thus resulting in overexpression of the protein, arising from the femur of a 24-year-old man. Our case provides a novel pathogenesis for IMT. An overview of cytogenetic abnormalities of IMT is also integrated into this report.
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- Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review. [Review]
- JEJ Evid Based Dent Pract 2019; 19(2):166-176
- CONCLUSIONS: Plasma rich in growth factors may bring advantages in some relevant clinical and radiographic outcomes, such as bone density and soft-tissue healing, after tooth extraction. It could also represent a useful tool for reducing adverse events, complications, and patients' discomfort, although it is still not quantifiable.