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22,216 results
  • Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity. [Journal Article]
    Sci Rep 2019; 9(1):14684Thiagarajan R, Varsha MKNS, … Saraboji K
  • This study investigated the potential of vitamin K1 as a novel lens aldose reductase inhibitor in a streptozotocin-induced diabetic cataract model. A single, intraperitoneal injection of streptozotocin (STZ) (35 mg/kg) resulted in hyperglycemia, activation of lens aldose reductase 2 (ALR2) and accumulation of sorbitol in eye lens which could have contributed to diabetic cataract formation. Howeve…
  • Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats. [Journal Article]
    J Biol Chem 2019Ohno RI, Ichimaru K, … Nagai R
  • Prolonged hyperglycemia generates advanced glycation end-products (AGEs), which are believed to be involved in the pathogenesis of diabetic complications. In the present study, we developed a polyclonal antibody against fructose-modified proteins (Fru-P antibody) and identified its epitope as glucoselysine (GL) by NMR and LC- electrospray ionization (ESI)- quadrupole TOF (QTOF) analyses and evalu…
  • Gelled non-toxic microemulsions: phase behavior & rheology. [Journal Article]
    Soft Matter 2019Peng K, Sottmann T, Stubenrauch C
  • Bicontinuous microemulsions gelled with a low molecular weight gelator have been shown to be an orthogonally self-assembled system. With the mechanical stability provided by the gel network, gelled non-toxic bicontinuous microemulsions have the potential to be an efficient transdermal drug delivery carrier. However, up to now no suitable system has been formulated for transdermal drug delivery. T…
  • Staphylococcus petrasii diagnostics and its pathogenic potential enhanced by mobile genetic elements. [Journal Article]
    Int J Med Microbiol 2019; :151355Vrbovská V, Kovařovic V, … Pantůček R
  • Staphylococcus petrasii is recently described coagulase negative staphylococcal species and an opportunistic human pathogen, still often misidentified in clinical specimens. Four subspecies are distinguished in S. petrasii by polyphasic taxonomical analyses, however a comparative study has still not been done on the majority of isolates and their genome properties have not yet been thoroughly ana…
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