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55,901 results
  • Material properties and cell compatibility of poly (γ-glutamic acid)-keratin hydrogels. [Journal Article]
    Int J Biol Macromol 2019Ijadi Bajestani M, Kader S, … Jafari A
  • Given the great demand for biopolymer and protein-based products from renewable resources, synthesis of a keratin-based hydrogel is presented herein. In this work, a novel hydrogel of Poly (γ-glutamic acid) (γ-PGA) and keratin was synthesized through facile EDC·HCl/HOBt chemistry. Since keratin main chain is rich in amino side groups, carboxyl groups in γ-PGA were crosslinked with multi terminate…
  • Rejuvenating the Brain With Chronic Exercise Through Adult Neurogenesis. [Journal Article]
    Front Neurosci 2019; 13:1000Trinchero MF, Herrero M, Schinder AF
  • The aging brain presents a general decline in plasticity that also affects hippocampal neurogenesis. Besides the well-known reduction in the rate of neuronal generation, development of new neurons is largely delayed in the aging brain. We have recently shown that this slow development is accelerated when middle-aged mice perform voluntary exercise in a running wheel. It is unclear whether the eff…
  • Proteostasis collapse is a driver of cell aging and death. [Journal Article]
    Proc Natl Acad Sci U S A 2019Santra M, Dill KA, de Graff AMR
  • What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage. Irreparably damaged proteins accumulate with age, increasingly distracting the chaperones from folding the healthy proteins the cell needs. The tipping point to death occ…
  • Changes in protein function underlies the disease spectrum in patients with CHIP mutations. [Journal Article]
    J Biol Chem 2019Madrigal SC, McNeil Z, … Schisler JC
  • Monogenetic disorders that cause cerebellar ataxia are characterized by defects in gait and atrophy of the cerebellum; however, patients often suffer from a spectrum of disease, complicating treatment options. Spinocerebellar ataxia autosomal recessive 16 (SCAR16) is caused by coding mutations in STUB1, a gene that encodes the multi-functional enzyme CHIP (C-terminus of HSC70-interacting protein)…
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