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7,769 results
  • Absence of SARS-CoV-2 in Semen of a COVID-19 Patient Cohort. [Journal Article]
    Andrology. 2020 Jun 29 [Online ahead of print]Guo L, Zhao S, … Yuan M
  • CONCLUSIONS: In this cohort of patients with a recent infection or recovering from COVID-19, there was no SARS-CoV-2 RNA detected in semen samples, which indicates the unlikely possibility of sexual transmission through semen at about 1 month after first detection.
  • Deletion of the PDZ-binding kinase (Pbk) gene does not affect male fertility in mice. [Journal Article]
    Reprod Fertil Dev. 2020 Jun; 32(10):893-902.Miki Y, Devi L, … Goel S
  • The PDZ-binding kinase (PBK) protein is localised exclusively in spermatogenic cells, such as spermatogonia, spermatocytes and round spermatids, of the adult testis. However, its role in male fertility remains unknown. Analysis of adult Pbk-knockout (KO) male mice showed no significant difference in the weight of the testes, epididymis and seminal vesicle compared with adult wild-type (WT) mice. …
  • Isolation, in vitro study, and stem cell markers for type A spermatogonia in a Characiformes species. [Journal Article]
    Mol Reprod Dev. 2020 Jun 18 [Online ahead of print]Dias GCM, Batlouni SR, … Borella MI
  • The objective of this study was to establish a protocol for the characterization, isolation, and culture of type A spermatogonia using specific molecular markers for these cells in fish. To this end, adult Prochilodus lineatus testes were collected and digested enzymatically and the resulting testicular suspension was separated using a discontinuous Percoll gradient, followed by differential plat…
  • Development and function of smooth muscle cells is modulated by Hic1 in mouse testis. [Journal Article]
    Development. 2020 Jun 18 [Online ahead of print]Uchida A, Sakib S, … Dobrinski I
  • In mammalian testis, contractile peritubular myoid cells (PMCs) regulate the transport of sperm and luminal fluid, while secreting growth factors and extra-cellular matrix (ECM) proteins to support the spermatogonial stem cell (SSC) niche. However, little is known about the role of testicular smooth muscle cells during the postnatal testicular development. Here we report age-dependent expression …
  • Production of functional eggs and sperm from in vitro-expanded type A spermatogonia in rainbow trout. [Journal Article]
    Commun Biol. 2020 Jun 15; 3(1):308.Iwasaki-Takahashi Y, Shikina S, … Yoshizaki G
  • Combining cryopreservation of germline stem cells (GSCs) with their subsequent transplantation into recipient fish is a powerful tool for long-term preservation of genetic resources of endangered fishes. However, application of this technique has been limited because endangered species sometimes have small gonads and do not supply enough GSCs to be used for transplantation. This limitation could …
  • Male Sterility and Reduced Female Fertility in SCAPER-Deficient Mice. [Journal Article]
    Hum Mol Genet. 2020 Jun 08 [Online ahead of print]Tatour Y, Bar-Joseph H, … Ben-Yosef T
  • Mutations in S-phase Cyclin A Associated Protein in the Endoplasmic Reticulum (SCAPER) cause a recessively-inherited multi-systemic disorder whose main features are retinal degeneration and intellectual disability. SCAPER, originally identified as a cell-cycle regulator, was also suggested to be a ciliary protein. Because Scaper mutant males are sterile, we set up to characterize their phenotype.…
  • [Effects of constant temperature on growth and gonad development of overwintering Whitmania pigra]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2020 Apr; 45(8):1873-1878.Zhang HN, Guo QS, … Guo LY
  • The present study was conducted to explore the effect of constant temperature overwintering on the growth, gonadal development and internal quality of the Wh. pigra which were in overwintering period. Wh. pigra which in overwintering period were placed in light incubator at 21 ℃, and the Wh. pigra that overwintered under natural conditions were used as control. That the changes of growth performa…
  • Long-Term Ex Vivo Expansion of Murine Spermatogonial Stem Cells in a Simple Serum-Free Medium. [Journal Article]
    Methods Mol Biol. 2020; 2155:165-182.Kubota H, Kakiuchi K
  • Spermatogonial stem cells (SSCs) possess both self-renewal and differentiation abilities to sustain lifelong production of enormous numbers of spermatozoa in males. SSCs hold a unique position among tissue-specific stem cells in adults because of their ability to transmit the genetic information to subsequent generations. Ex vivo expansion of SSCs in conjunction with their transplantation is high…
  • 'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'. [Journal Article]
    Andrology. 2020 May 22 [Online ahead of print]Micati DJ, Radhakrishnan K, … Loveland KL
  • CONCLUSIONS: This is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.
  • Spermatogonial asynchrony in Tex14 mutant mice lacking intercellular bridges. [Journal Article]
    Reproduction. 2020 May 01 [Online ahead of print]Rezende-Melo CA, Caldeira-Brant AL, … Chiarini-Garcia H
  • The existence of cytoplasmic passages between germ cells and their potential function in the control of the spermatogenic process has long been an intriguing question. Evidence of the important role of such structures, known as intercellular bridges (ICB), in spermatogenesis has been implicated by the failure of spermatogenesis in Tex14 mutant mice, which lack the ICBs, to progress past the pachy…
  • Hsa-miR-1908-3p Mediates the Self-Renewal and Apoptosis of Human Spermatogonial Stem Cells via Targeting KLF2. [Journal Article]
    Mol Ther Nucleic Acids. 2020 Jun 05; 20:788-800.Chen W, Cui Y, … He Z
  • Spermatogenesis depends on precise epigenetic and genetic regulation of spermatogonial stem cells (SSCs). However, it remains largely unknown about the roles and mechanisms of small noncoding RNA in regulating the self-renewal and apoptosis of human SSCs. Notably, we have found that Homo sapiens-microRNA (hsa-miR)-1908-3p is expressed at a higher level in human spermatogonia than pachytene sperma…
  • Tributyltin impaired spermatogenesis and reproductive behavior in male zebrafish. [Journal Article]
    Aquat Toxicol. 2020 Jul; 224:105503.Lan XR, Li YW, … Liu ZH
  • Tributyltin (TBT) was reported to affect sexual behavior and gametogenesis in fish. However, the modes of action involved are largely unclear. In order to elucidate the toxicological mechanisms of TBT in reproduction, zebrafish (Danio rerio) males were exposed to TBT at concentrations of 100 and 500 ng/L for 28 days. After exposure, the sperm count of the treated fish was sharply decreased though …
  • Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats. [Journal Article]
    J Toxicol Pathol. 2020 Apr; 33(2):87-95.Radad K, Amir YE, … Moldzio R
  • This study investigated the protective effects of minocycline against acrylamide (ACR)-induced neurotoxicity and testicular damage in Sprague-Dawley rats. Forty rats were divided into five groups (eight rats each). Group I received saline (0.5 mL/rat) daily for 10 days and served as the untreated control group. Group II received ACR (30 mg/kg body weight (b.w.)) daily for 10 days. Group III recei…
  • Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. [Journal Article]
    Environ Pollut. 2020 May 01; 264:114710.Forner-Piquer I, Beato S, … Carnevali O
  • Bisphenol A (BPA), a monomer used for polycarbonate manufacture, has been widely reported as an endocrine-disrupting chemical (EDC). Among other alterations, BPA induces reproductive dysfunctionalities. Changes in the endocannabinoid system (ECS) have been recently shown to be associated with reproductive disorders. The ECS is a lipid-based signaling system (cannabinoid receptors, endocannabinoid…
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