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(sphingo )
61 results
  • Lipidomics, Atrial Conduction, and Body Mass Index. [Journal Article]
    Circ Genom Precis Med 2019; 12(7):e002384Del Greco M F, Foco L, … Pattaro C
  • CONCLUSIONS: Increased %PC 38:3 levels are consistently associated with longer PWD, partly because of the confounding effect of BMI. The causal effect of BMI on PWD reinforces evidence of BMI's involvement into atrial electrical activity.
  • Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide. [Review]
    Adv Biol Regul 2018; 70:40-50Nikolova-Karakashian M
  • Sphingolipids are class of metabolically distinct lipids that play structural and signaling functions in all organisms. Sphingolipid metabolism is deregulated during various diseases such as cancer, neurological and immune disorders, and metabolic syndrome. With the advancement of sphingo-lipidomics and sphingo-genomics, an understanding of the specific roles of ceramide, the quintessential bioac…
  • A Comparative Study of Human Saposins. [Journal Article]
    Molecules 2018; 23(2)Garrido-Arandia M, Cuevas-Zuviría B, … Pacios LF
  • Saposins are small proteins implicated in trafficking and loading of lipids onto Cluster of Differentiation 1 (CD1) receptor proteins that in turn present lipid antigens to T cells and a variety of T-cell receptors, thus playing a crucial role in innate and adaptive immune responses in humans. Despite their low sequence identity, the four types of human saposins share a similar folding pattern co…
  • Phytosphingosine is a novel activator of GPR120. [Journal Article]
    J Biochem 2018; 164(1):27-32Nagasawa T, Nakamichi H, … Mitsutake S
  • GPR120 is a receptor for long chain fatty acids and is expressed in small intestinal endocrine cells, L cells and adipose tissue. Activation of GPR120 promotes the secretion of incretin GLP-1, which is known to have effects on anti-metabolic syndrome. As such, GPR120 is a potential target of pharmaceuticals for type II diabetes. In this study, we performed ligand-screening for GPR120 on glycero- …
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