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8,789 results
  • The effect of spironolactone on thyroid autoimmunity in euthyroid men with Hashimoto's thyroiditis. [Journal Article]
    J Clin Pharm Ther 2019Krysiak R, Kowalcze K, Okopień B
  • CONCLUSIONS: At baseline, there was no difference between the treatment arms in terms of thyroid antibody titres, hormone levels and the calculated parameters of thyroid homeostasis. Thirty-two patients completed the study. Spironolactone increased thyroid antibody titres, decreased testosterone and 25-hydroxyvitamin D levels and reduced SPINA-GT. The drug produced a neutral effect on serum levels of thyrotropin, free thyroid hormones, Jostel's thyrotropin index and SPINA-GD. The effect of spironolactone on antibody titres correlated with treatment-induced changes in SPINA-GT, testosterone and 25-hydroxyvitamin D. No significant changes in antibody titres, hormone levels and the calculated parameters of thyroid homeostasis were observed in spironolactone-naïve men.The obtained results indicate that spironolactone may exert an unfavourable effect on progression of autoimmune thyroiditis in men.
  • Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy. [Review]
    Front Endocrinol (Lausanne) 2019; 10:575Sabbadin C, Andrisani A, … Armanini D
  • Aldosterone is the main mineralocorticoid hormone, responsible of the regulation of fluid and electrolyte balance and blood pressure. It acts also as a pro-inflammatory factor responsible of an increased cardiovascular risk, independent from blood pressure values. After the discovery of mineralocorticoid receptor (MR) in mononuclear leukocytes, further studies supported its role in inflammatory a…
  • Nonsurgical hair restoration treatment. [Journal Article]
    Cutis 2019; 104(1):17-24Nazarian RS, Farberg AS, … Goldenberg G
  • Patterned hair loss is common and can negatively impact quality of life. Patients often seek nonsurgical treatment options as a first-line measure to avoid undue risks and expense associated with surgery. This article discusses these noninvasive treatment options, with a focus on minoxidil, finasteride, dutasteride, spironolactone, low-level laser therapy (LLLT), platelet-rich plasma (PRP), micro…
  • [Spironolactone in resistant essential hypertension]. [Journal Article]
    Presse Med 2019Lorthioir A, Belmihoub I, … Amar L
  • Resistant hypertension is defined as uncontrolled blood pressure (BP) despite three antihypertensive agents including a diuretic (thiazide diuretic if renal function is normal or loop diuretic in case of chronic kidney disease with eGFR<30mL/min), a renin-angiotensin system blocker (ARB or ACEI) and a calcium channel blocker, at optimal doses. Resistance must be confirmed by out-of-office measure…
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