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Unbound Medicine.
(spironolactone)
9,021 results
  • Comparing acne follow-up: teledermatology versus outpatient dermatology visits. [Journal Article]
    Dermatol Online J. 2020 Apr 15; 26(4)Khosravi H, Zhang S, … English Iii JC
  • The application of teledermatology for evaluating acne patients has yielded comparable therapeutic outcomes with traditional face-to-face evaluation, but follow-up compliance between these modalities is not well-studied. Our objective is to compare the rate and duration of follow-up between acne patients initially evaluated by teledermatology versus in-person outpatient consultation. Electronic m…
  • Treatment of primary hyperaldosteronism. [Review]
    Med Clin (Barc). 2020 Jun 22 [Online ahead of print]Araujo-Castro M
  • Primary aldosteronism is associated with higher cardiovascular and renal morbidity and mortality than essential hypertension in age- and sex-matched patients with the same degree of blood pressure elevation. Therefore, it is essential to establish a specific treatment to avoid the deleterious effects of aldosterone excess. Although adrenalectomy is generally considered the treatment of choice in …
  • FASCE, the benefit of spironolactone for treating acne in women: study protocol for a randomized double-blind trial. [Journal Article]
    Trials. 2020 Jun 25; 21(1):571.Poinas A, Lemoigne M, … Dréno B
  • CONCLUSIONS: The treatment frequently used in female acne is systemic antibiotics with many courses, as it is a chronic inflammatory disease. In the context of the recent World Health Organisation (WHO) revelation about the serious, worldwide threat to public health of antibiotic resistance, this trial could give the physician another alternative in the treatment of adult female acne instead of using isotretinoin, which is more complex to manage.
  • Game Changer in Acne Treatment. [Journal Article]
    J Drugs Dermatol. 2020 Mar 01; 19(3):28.Kircik LH
  • Of the four primary pathogenic factors that drive acne vulgaris—androgen excess, increased sebum production, faulty keratinization, and overgrowth of C. acnes—androgen excess has been the most elusive therapeutic target. Oral contraceptive pills (OCPs) have direct effect on circulating hormones, but their potential use is limited to a subset of women. As such, a sizable portion of the…
  • Drospirenone 4 mg-only pill (DOP) in 24+4 regimen: a new option for oral contraception. [Journal Article]
    Expert Rev Clin Pharmacol. 2020 Jun 13 [Online ahead of print]Chiara Del Savio M, De Fata R, … Grandi G
  • Although progestin-only pills (POPs) are effective methods of hormonal contraception, their use is still relatively infrequent, mainly for their unpredictable effect on menstrual bleeding. A new oestrogen-free contraceptive consisting of 4 mg drospirenone (DRSP) for 24 days with a 4-day hormone-free interval has been developed to address this need, named the DRSP-only pill. DRSP is a potent proge…
  • ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS. [Journal Article]
    J Pharm Biomed Anal. 2020 May 22; 188:113311.Sarcan ET, Tas A, … Hekimoglu B
  • X-ray is used in several areas for analysis, imaging, sterilisation and security. X-ray machines are increasingly used in the entrance of the airports, shopping centres, etc. for security purposes. Therefore, human beings and belongings are frequently exposed to X-ray by transiting these checkpoints at various sites such as airports, shopping centres etc. This study aims is to investigate the X-r…
  • Prevalence of Primary Aldosteronism in Hypertensive Kidney Transplant Recipients: A Cross-Sectional Study. [Journal Article]
    Clin Transplant. 2020 Jun 05 [Online ahead of print]Garg N, Votruba CD, … Mandelbrot DA
  • Due to high prevalence of primary aldosteronism (PA) in the general hypertensive population, and its association with worse cardiovascular and renal outcomes, the 2016 Endocrine Society Guidelines explicitly recognize PA as a major public health issue requiring urgent attention. Its prevalence in hypertensive kidney transplant recipients (KTRs) is unknown. In this cross-sectional study, we screen…
  • Safety and Tolerability of Neurohormonal Antagonism in Cardiac Amyloidosis. [Journal Article]
    Eur J Intern Med. 2020 May 29 [Online ahead of print]Aimo A, Vergaro G, … Emdin M
  • CONCLUSIONS: ACEi/ARB and MRA can be safely used in CA, provided that no contraindications are present, treatment is started at a low dose and slowly up-titrated, and patients are monitored quite closely. Beta-blocker therapy is less tolerated in patients with AL amyloidosis and/or worse haemodynamic function.
  • Aldosterone receptor antagonists. [Journal Article]
    Ann Endocrinol (Paris). 2020 May 27 [Online ahead of print]Azizi M
  • Blocking the mineralocorticoid receptor (MR) is one of the most effective ways of reducing blood pressure in patients with resistant hypertension and improving cardiovascular prognosis in patients with heart failure with reduced ejection fraction and left ventricular dysfunction after myocardial infarction. Blockade of the biological effects of aldosterone has mostly been achieved with spironolac…
  • Spironolactone dose in Heart Failure with Preserved Ejection Fraction: findings from TOPCAT. [Journal Article]
    Eur J Heart Fail. 2020 May 25 [Online ahead of print]Ferreira JP, Rossello X, … Zannad F
  • CONCLUSIONS: Spironolactone (but not placebo) was used at lower doses among the elderly, those with renal dysfunction and with higher potassium levels. The effect of spironolactone was homogenous across these subgroups. In patients unable to tolerate "target" doses, a low-dose strategy should be preferred to stopping treatment. This article is protected by copyright. All rights reserved.
  • Patiromer plus spironolactone in resistant hypertension and CKD. [Journal Article]
    Drug Ther Bull. 2020 May 23 [Online ahead of print]
  • Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers' attention and help them keep up to date. To do this, we produce succinct, contextualised summaries of the information concerned.
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