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2,304 results
  • Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway. [Review]
    J Biomed Sci 2019; 26(1):96Wakabayashi G, Lee YC, … Yen Y
  • Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death receptor-1 (PD-1) and its ligand (PD-L1) demonstrate impressive clinical benefits in clinical trials. In this review, we present backg…
  • Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates. [Journal Article]
    Front Endocrinol (Lausanne) 2019; 10:727Bender HR, Campbell GE, … Duffy DM
  • Angiogenesis is essential to both ovulation and the formation of the corpus luteum. The thrombospondin (THBS) family of glycoproteins plays diverse roles in regulation of angiogenesis, but the role of these vascular regulators in ovulation and luteinization remain to be elucidated. Using the cynomolgus macaque as a model for human ovulation, we demonstrated that levels of THBS1 mRNA and protein i…
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