- Secukinumab immunogenicity over 52 weeks in patients with psoriatic arthritis and ankylosing spondylitis. [Journal Article]
- JRJ Rheumatol 2019 Jun 15
- CONCLUSIONS: Secukinumab treatment was associated with a low (<1%) incidence of immunogenicity in PsA and AS patients.
- Nanoparticle induced biological disintegration: A new phase separated pretreatment strategy on microalgal biomass for profitable biomethane recovery. [Journal Article]
- BTBioresour Technol 2019 Jun 08; 289:121624
- This study involves the application of new phase separated biological pretreatment (PSBP) strategy on microalgal biomass using the nickel nanoparticle induced cellulase secreting bacterial disintegra…
This study involves the application of new phase separated biological pretreatment (PSBP) strategy on microalgal biomass using the nickel nanoparticle induced cellulase secreting bacterial disintegration. Particularly, interest was focussed on cell wall weakening (CWW) of microalgae biomass besides the cell disintegration (CD) and release of organics. During CWW, protein, carbohydrate, cellulose, hemicellulose and DNA were used as evaluation indexes. Similarly, during CD, soluble chemical oxygen demand was used as evaluation index to assess the disintegration effect. A higher CWW was achieved at nickel nanoparticle (Np) dosage of 0.004 g/g SS. During CD, a clear demarcation in biomass solubilisation was achieved by PSBP (36%) than the sole biological pretreatment -BP (24%). The biomethanogenesis test results showed that enhanced methane production of 411 mL/g COD was achieved by PSBP than BP. Energy analysis showed that a higher net energy production of 6.467 GJ/d was achieved by PSBP.
- Technical Consideration for TLIF Cage Retrieval and Deformity Correction With Anterior Interbody Fusion in Lumbar Revision Surgeries. [Journal Article]
- SDSpine Deform 2019; 7(4):633-640
- CONCLUSIONS: Anterior approach is a suitable technique for TLIF cage removal while preserving the end plates for subsequent optimal interbody fusion at the index level in symptomatic pseudoarthrosis patients or those with clinical deformity. ALIF with HLCs with or without Ponte osteotomy can restore segmental and overall sagittal alignment.
- A comprehensive ecological management approach for northern mountain rivers in China. [Journal Article]
- CChemosphere 2019 Jun 07; 234:25-33
- Mountain rivers not only play an important role in flood control, but also perform other functions such as conserving water sources, regulating microclimate, and maintaining water ecology and biodive…
Mountain rivers not only play an important role in flood control, but also perform other functions such as conserving water sources, regulating microclimate, and maintaining water ecology and biodiversity. Because the conventional approach to managing mountain rivers overlooks the intrinsic requirements of river water, alters the natural landscape of river channels, and destroys habitats, it leads to water quality deterioration and ecological imbalance. The Yang River is characteristic of northern mountain rivers, and so the ecological management project for this river - at the site of the forthcoming Beijing 2022 Olympic Winter Games - was selected as an example of comprehensive ecological management. This comprises an ecological, permeable dam-pond-wetland system. Results showed that: (Zhu et al., 2006): river water quality improved substantially; improvements in the water quality indices exhibited the trend suspended solids (SS) > ammonium-nitrogen (NH3-N) > chemical oxygen demand (COD) (Mikus et al., 2019). The Shannon-Wiener diversity index, Margalef species richness index, and Pielou evenness index all indicated increased phytoplankton by an average of 52.1%, 2.4%, and 98.9%, respectively. These three diversity indices showed increased zooplankton, by an average of 1.2%, 0.5%, and 3.3%, respectively. Water quality in the Yang River was found to have changed from moderate to light pollution (Kuemmerlen et al., 2019). Each subsystem increased removal of pollutants from the Yang River. Removal efficiencies of COD, total phosphorous (TP), total nitrogen (TN), NH3-N, and SS by the dam system were 28.57%, 28.3%, 20.5%, 24.0%, and 95%, respectively. Corresponding pollutant removal efficiencies by the pond system were 16.7%, 29.58%, 21.63%, 20.0%, and 99.8%, respectively. The wetland system achieved pollutant removal efficiencies of 44.0%, 17.1%, 6.7%, 13.9%, and 80.0%, respectively. This approach can mitigate flood control pressure, restore river ecology, and improve water quality in northern mountain rivers, and allow such rivers to achieve "retention-storage-restoration" effects. The ecological treatment approach provides an important theoretical foundation and technical reference for global mountain river management, and is especially applicable to mountain rivers in cold and arid regions in the northern hemisphere.
- Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. [Journal Article]
- EJEur J Med Chem 2019 Jun 06; 178:380-389
- The development of Tyrosinase inhibitors (TYRIs) could represent an efficacious strategy for pharmacological intervention on skin pathologies related to aberrant production of melanin. Based on in si…
The development of Tyrosinase inhibitors (TYRIs) could represent an efficacious strategy for pharmacological intervention on skin pathologies related to aberrant production of melanin. Based on in silico studies we designed and tested a library of twenty-four compounds bearing the 4-(4-fluorobenzyl)piperazin-1-yl]-fragment. As result, we identified several compounds with excellent inhibit effects at low micromolar concentration against TYR from Agaricus bisporus (TyM). Among them, compound 25 (IC50 = 0.96 μM) proved to be ∼20-fold more potent than the reference compound kojic acid (IC50 = 17.76 μM) having wide applications in the cosmetics and pharmaceutical industries. The mode of interaction of active inhibitor 25 was deciphered by means of crystallography as well as molecular docking and these results were consistent with kinetic experiments. Moreover, the identified compound 25 exhibited no considerable cytotoxicity and showed anti-melanogenic effects on B16F10 melanoma cells. Therefore, a combination of computational and biochemical approaches could represent a rational guidelines for further structural modification of this class of compounds as future anti-melanogenic agents.
- Effect of NaCl substitutes on the physical, microbial and sensory characteristics of Harbin dry sausage. [Journal Article]
- MSMeat Sci 2019 Jun 03; 156:205-213
- The effect of partial replacement of NaCl by using sodium substitutes (SS) on the physical, microbial and sensory characteristics of Harbin dry sausage was investigated. There were three salt formula…
The effect of partial replacement of NaCl by using sodium substitutes (SS) on the physical, microbial and sensory characteristics of Harbin dry sausage was investigated. There were three salt formulations, including control (100% NaCl), NaCl partly substituted by KCl (SS1) (70% NaCl and 30% KCl), and NaCl partly substituted by KCl combined with other components (SS2) (70% NaCl, 20% KCl, 3.5% maltodextrin, 4% L-Lys, 1% L-Ala, 0.5% citric acid and 1% Ca-lactate). After a 12-day fermentation, the higher moisture content and Aw and lower pH were found in the SS2 treatment, compared to the control and SS1 treatments (P < .05). A decreased microbial diversity during fermentation was found in all sausages, and Staphylococcus spp. and Lactobacillus spp. became the dominant genera. Additionally, the SS2 treatment showed a higher L*-value and lower hardness and chewiness values (P < .05). Therefore, the formulation of SS2 could achieve a NaCl reduction of 30% in Harbin dry sausages with a better sensory acceptability.
- Effect of solar photo-Fenton process in raceway pond reactors at neutral pH on antibiotic resistance determinants in secondary treated urban wastewater. [Journal Article]
- JHJ Hazard Mater 2019 Jun 06; 378:120737
- Solar photo-Fenton process in raceway pond reactors was investigated at neutral pH as a sustainable tertiary treatment of real urban wastewater. In particular, the effect on antibiotic resistance det…
Solar photo-Fenton process in raceway pond reactors was investigated at neutral pH as a sustainable tertiary treatment of real urban wastewater. In particular, the effect on antibiotic resistance determinants was evaluated. An effective inactivation of different wild bacterial populations was achieved considering total and cefotaxime resistant bacteria. The detection limit (1 CFU mL-1) was achieved in the range 80-100 min (5.4-6.7 kJ L-1 of cumulative solar energy required) for Total Coliforms (TC) (40-60 min for resistant TC, 4.3-5.2 kJ L-1), 60-80 min (4.5-5.4 kJ L-1) for Escherichia coli (E. coli) (40 min for resistant E. coli, 4.1-4.7 kJ L-1) and 40-60 min (3.9-4.5 kJ L-1) for Enterococcus sp. (Entero) (30-40 min for resistant Entero, 3.2-3.8 kJ L-1) with 20 mg L-1 Fe2+ and 50 mg L-1 H2O2. Under these mild oxidation conditions, 7 out of the 10 detected antibiotics were effectively removed (60-100%). As the removal of antibiotic resistance genes (ARGs) is of concern, no conclusive results were obtained, as sulfonamide resistance gene was reduced to some extent (relative abundance <1), meanwhile class 1 integron intI1 and β-lactam resistance genes were not affected. Accordingly, more research and likely more intensive oxidative conditions are needed for an efficient ARGs removal.
- Quality of life in patients with polyneuropathy associated with different types of monoclonal gammopathy of undetermined significance. [Journal Article]
- ANActa Neurol Belg 2019 Jun 14
- Polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS-PNP) has a chronic and slowly progressive course but can lead to significant disability and reduced quality of …
Polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS-PNP) has a chronic and slowly progressive course but can lead to significant disability and reduced quality of life (QoL). The aim of this study was to analyze QoL in MGUS-PNP patients and to determine its predictors. Our study included 51 patients diagnosed with MGUS-PNP (23.5% with IgM, 66.7% IgG or IgA, 7.8% undetermined paraprotein, 2.0% light chains). QoL was assessed using the SF-36 questionnaire. The Medical Research Council Sum Score (MRC-SS), INCAT disability and sensory scores, ataxia score, Krupp's Fatigue Severity Scale and Beck's Depression Inventory were also used. Total SF-36 score was 50.0 ± 21.4 and no difference was observed between IgM and IgG/IgA MGUS-PNP. Physical composite score was worse than mental (44.4 ± 21.4 vs. 54.5 ± 20.9). Following factors showed correlation with SF-36 total score in univariate analysis: INCAT disability score, MRC-SS, INCAT sensory score, level of ataxia, fatigue and depression (p < 0.01). Significant predictors of worse SF-36 total score in our MGUS-PNP patients were depression (β = - 0.46, p < 0.01), fatigue (β = - 0.32, p < 0.01) and INCAT disability score (β = - 0.27, p < 0.01). QoL in MGUS-PNP is equally affected in patients with different types of paraprotein. MGUS-PNP patients with more severe functional disability, fatigue and depression need special attention of clinicians since they could be at higher risk to have worse QoL. This should be taken into account when treating subjects with MGUS-PNP.
- Diabetes mellitus as a risk factor for intervertebral disc degeneration: a critical review. [Review]
- ESEur Spine J 2019 Jun 14
- CONCLUSIONS: The clinical evidence is not consistent, but weakly supports the relationship between DM and IVDD. However, the laboratory studies consistently suggest that DM interferes with multipronged aberrant molecular and biochemical pathways that provoke IVDD. Taken as a whole, the strong laboratory evidence and the weak clinical studies implicate DM as a distinct contributing factor for IVDD. These slides can be retrieved under Electronic Supplementary Material.
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- Fluid-Blood Level and Hematoma Expansion in a Cerebral Amyloid Angiopathy-Associated Intracerebral Hematoma. [Journal Article]
- AJAm J Case Rep 2019 Jun 15; 20:844-850
- CONCLUSIONS: We report a CAA-associated ICH case showing hematoma expansion with a fluid-blood level. Intraparenchymal fluid-blood level suggests extravasation of blood into pre-existing cystic cavities because of hematoma liquefaction. Thus, fluid-blood levels are an important finding of hematoma expansion in acute CAA-associated ICH, and early treatment should be considered.