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82,480 results
  • The use of aliskiren as an antifibrotic drug in experimental models: A systematic review. [Journal Article]
    Drug Dev Res 2019Altarejo Marin T, Machado Bertassoli B, … Feder D
  • Aliskiren is an oral antihypertensive medication that acts by directly inhibiting renin. High levels of circulating renin and prorenin activate the pathological signaling pathway of fibrosis. This drug also reduces oxidative stress. Thus, the aim of this systematic review is to analyze experimental studies that show the actions of aliskiren on fibrosis. PubMed and LILACS databases were consulted …
  • Adaptive immunity: an emerging player in the progression of NAFLD. [Review]
    Nat Rev Gastroenterol Hepatol 2019Sutti S, Albano E
  • In the past decade, nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver disease and cirrhosis, as well as an important risk factor for hepatocellular carcinoma (HCC). NAFLD encompasses a spectrum of liver lesions, including simple steatosis, steatohepatitis and fibrosis. Although steatosis is often harmless, the lobular inflammation that characterizes nonalcoholic…
  • Angiotensinogen in Hepatocytes Contributes to Western Diet-induced Liver Steatosis. [Journal Article]
    J Lipid Res 2019Tao XR, Rong JB, … Wang JA
  • Non-alcoholic fatty liver disease (NAFLD) is considered as a liver manifestation of metabolic disorders. Previous studies indicate that renin-angiotensin system (RAS) plays a complex role in NAFLD. As the only precursor of RAS, decreased angiotensinogen (AGT) profoundly impacts RAS bioactivity. Here we investigated the role of hepatocyte-derived AGT in liver steatosis. AGT floxed mice (hepAGT+/+)…
  • Phenotyping diabetic cardiomyopathy in Europeans and South Asians. [Journal Article]
    Cardiovasc Diabetol 2019; 18(1):133Paiman EHM, van Eyk HJ, … Lamb HJ
  • CONCLUSIONS: Diabetic cardiomyopathy was characterized by impaired LV diastolic function in South Asians and Europeans. Increased LV mass was solely observed among South Asian T2D patients, whereas differences in myocardial triglyceride content between T2D patients and controls were only present in the European cohort. The diabetic cardiomyopathy phenotype may differ between subsets of T2D patients, for example across ethnicities, and tailored strategies for T2D management may be required.
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