- Three-dimensional segmentation and symbolic representation of cerebral vessels on 3DRA images of arteriovenous malformations. [Journal Article]Comput Biol Med 2019; 115:103489CB
- CONCLUSIONS: A relevant vascular network modelization has been developed that constitutes a breakthrough in the assistance of neuroradiologists for AVM endovascular embolization planning.
- "Synchronous versus Staged Carotid Endarterectomy (CEA) and Coronary Artery Bypass Graft (CABG) for Patients with Concomitant Severe Coronary and Carotid Artery Stenosis: a Systematic Review and Meta-analysis". [Review]Ann Vasc Surg 2019AV
- CONCLUSIONS: Patients in the simultaneous CEA and CABG group had a significantly higher risk of 30-day mortality and stroke and lower risk for MI as compared to staged CEA and CABG group. The rates of TIA, postoperative bleeding and pulmonary complications were similar between the two groups. Future randomized trials or prospective cohorts are needed to validate our results.
- Rational and design of the Baseline Interatrial block and Transcatheter aortic valve implantation (BIT) registry. [Journal Article]J Electrocardiol 2019; 57:100-103JE
- CONCLUSIONS: The BIT registry will study, for the first time, the influence of previous IAB in the need of permanent pacemaker after TAVI: This large registry will also provide information regarding the association of this and other ECG parameters with prognosis.
- Infective endocarditis caused by Streptococcus acidominimus. [Journal Article]Am J Health Syst Pharm 2019AJ
- CONCLUSIONS: An 81-year-old Caucasian man underwent an elective transcatheter aortic valve implantation due to his severe aortic valve stenosis. He presented to the hospital 3 weeks later with a 1-week history of fever (39ºC) that did not resolve following a 3-day course of azithromycin and a 5-day course of ciprofloxacin. Three sets of blood sample cultures were taken. Empirical antimicrobial treatment was initiated to target gram-positive and gram-negative microorganisms and consisted of vancomycin 1 g intravenous (i.v.) every 12 hours and imipenem-cilastatin 500 mg i.v. every 6 hours. After 48 hours, the blood culture was positive for S. acidominimus. The strain was sensitive to ampicillin, cephalosporins, tetracycline, and vancomycin. It was resistant to penicillin, macrolides, trimethoprim-sulfamethoxazole, and fosfomycin. Transesophageal echocardiography showed a small mobile vegetation attached to the anterior mitral valve leaflet, along with mild mitral regurgitation. The patient was diagnosed with native mitral valve infective endocarditis, and imipenem-cilastatin was discontinued. The patient showed clinical and laboratory improvement during his 2-week hospitalization. A peripherally inserted central catheter was put in place, and the patient was discharged on i.v. vancomycin to complete a total of 6 weeks treatment, after which the infection resolved.An 81-year-old man diagnosed with mitral valve endocarditis caused by S. acidominimus was successfully treated with vancomycin.
- On-site evaluation of CT-based fractional flow reserve using simple boundary conditions for computational fluid dynamics. [Journal Article]Int J Cardiovasc Imaging 2019IJ
- Fractional flow reserve (FFR) is an established method for diagnosing physiological coronary artery stenosis. A method for computing FFR using coronary computed tomography (CT) images was recently developed. However, its calculation requires off-site supercomputer analysis. Here, we report the preliminary result of a method using simple estimation of boundary conditions. The lumen boundaries of t…
Fractional flow reserve (FFR) is an established method for diagnosing physiological coronary artery stenosis. A method for computing FFR using coronary computed tomography (CT) images was recently developed. However, its calculation requires off-site supercomputer analysis. Here, we report the preliminary result of a method using simple estimation of boundary conditions. The lumen boundaries of the coronary arteries were semi-automatically delineated using full width at half maximum of CT number profiles. The computational fluid dynamics (CFD) of the blood flow was performed using the boundary conditions of a fixed pressure at the coronary ostium and flow rates at each outlet. The total inflow at the coronary ostium was estimated based on the uniform wall shear stress hypothesis and corrected using a hyperemic multiplier to gain a hyperemic flow rate. The flow distribution from a parent vessel to the downstream daughter vessels was determined according to Murray's law. FFR estimated by CFD was calculated as FFRCFD = Pd/Pa. We collected patients who underwent coronary CT and coronary angiography followed by invasively measured FFR and compared FFRCFD with FFR. Sensitivity, specificity, and correlations were assessed. A total of 48 patients and 72 arteries were assessed. The correlation coefficient of FFRCFD with FFR was 0.56. The cut-off value was ≤ 0.80, sensitivity was 59.1%, and specificity was 94.0%. CFD-based FFR using simple boundary conditions for on-site clinical computation provided FFRCFD values that were moderately correlated with invasively measured FFR.
- A novel model of cerebral hyperperfusion with blood-brain barrier breakdown, white matter injury, and cognitive dysfunction. [Journal Article]J Neurosurg 2019; :1-13JN
- CONCLUSIONS: The authors report a novel CHP model in rats that represents the pathophysiology of CHP observed in various clinical scenarios. This model was produced without the use of pharmacological agents; therefore, it is ideal to study the pathology of CHP as well as to perform preclinical drug trials.
- [Penile malakoplakia associated with lichen sclerosus]. [Journal Article]Ann Dermatol Venereol 2019AD
- CONCLUSIONS: Malakoplakia of the genital mucosa is rare, with only one case of involvement of the glans being reported in the literature. The association with lichen sclerosus is probably not fortuitous but could in fact be due to chronic urinary tract infection favored by stenosis of the urethral meatus and possible local immunodepression following prolonged application of clobetasol.We report a case of penile malakoplakia associated with chronic E. coli urinary tract infection, due originally to associated genital lichen sclerosus.
- [The nerve root syndrome in small animals - A review focussing on pathophysiology and therapy in the dog]. [Journal Article]Tierarztl Prax Ausg K Kleintiere Heimtiere 2019; 47(5):344-357TP
- A large variety of etiologies is considered to be the cause of nerve root syndrome in dogs. Lateralized disc herniation, foraminal stenosis and malignant as well as benign nerve sheath tumors are some of the most important triggers described. The clinical signs of a nerve root syndrome are characterized by monoparesis in combination with progressive lameness, which may be accompanied by an elevat…
A large variety of etiologies is considered to be the cause of nerve root syndrome in dogs. Lateralized disc herniation, foraminal stenosis and malignant as well as benign nerve sheath tumors are some of the most important triggers described. The clinical signs of a nerve root syndrome are characterized by monoparesis in combination with progressive lameness, which may be accompanied by an elevation of the affected limb. Although the problem is well known among clinicians, there is no review article in the veterinary literature that specifically covers the subject of "nerve root syndrome in small animals". Mostly, this is merely mentioned as a symptom of its potential etiologies, as the so-called "nerve root sign" or "nerve root signature". In the pathophysiology of nerve root compression or irritation, a number of biomechanical and biochemical factors play a role. These occur individually or in combination and may lead to the same changes. The pathophysiology of the syndrome seems to focus around changes in microcirculation. These microcirculation disorders not only lead to pathomorphological changes such as edema formation, demyelination and axon death, but also initiate a cascade of reactions at the site of damage as well as in the central nervous tissue. This leads to the release of various neuropeptides, modulation of nerve excitability and impulse transmission. Different pathomechanisms therefore often lead to a uniform damage pattern, which makes it difficult to point out the original triggering factors. The body's response to these factors determines whether a nerve root syndrome actually develops or not. The treatment of the cause, if found, and an individual and multimodal pain therapy seem to be the most successful therapeutic approaches for nerve root syndrome in dogs.
- Utilization of Cu-nanoparticles as medication agent to reduce atherosclerotic lesions of a bifurcated artery having compliant walls. [Journal Article]Comput Methods Programs Biomed 2019; 184:105123CM
- CONCLUSIONS: The circulation of blood is considered to be different from pressure between portions of atherosclerotic and non-atherosclerotic artery. Shear stress is reduces by changing the bifurcation angle for daughter artery while trend is reversed for parent artery. The size of inner circularting bolus decreases by changing compliant parameter for parent artery while shape is changed for daughter artery.
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- Relationship between cerebrovascular atherosclerotic stenosis and rupture risk of unruptured intracranial aneurysm: A single-center retrospective study. [Journal Article]Clin Neurol Neurosurg 2019; 186:105543CN
- CONCLUSIONS: We observed substantial differences in the severity of atherosclerotic stenosis, parent-artery stenosis, number of stenotic arteries, and intracranial/extracranial stenosis as indicators between ruptured and unruptured aneurysms. CAS is significantly associated with the risk of intracranial aneurysm rupture, whether in patients aged ≥65 years or <65 years. These findings indicate the clinical significance of CAS in IAR.