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19,988 results
  • Infections in Deep Brain Stimulator Surgery. [Journal Article]
    Cureus 2019; 11(8):e5440Bernstein JE, Kashyap S, … Ananda A
  • CONCLUSIONS: Infections after DBS implantation and IPG replacement occurred in 3% and 0.8% of patients respectively in our study which is lower than reported historically. Early infections were more common. No intracranial infections were found. Intra-operative use of vancomycin was not shown to decrease risk of infection after electrode implantation surgery or IPG replacement. However, in our study it was shown to increase risk of infection after electrode implantation surgery. Treatment includes antibiotic therapy and debridement with or without removal of hardware. DBS hardware can be safely left in place in select patients who may have significant adverse effects if it is removed.
  • Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. [Journal Article]
    Sci Rep 2019; 9(1):14848Nascimento M, Gombault A, … Couillin I
  • Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interfer…
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