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23,524 results
  • Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. [Journal Article]
    Nat Commun 2019; 10(1):4624Moriyama M, Koshiba T, Ichinohe T
  • Cytosolic mitochondrial DNA (mtDNA) activates cGAS-mediated antiviral immune responses, but the mechanism by which RNA viruses stimulate mtDNA release remains unknown. Here we show that viroporin activity of influenza virus M2 or encephalomyocarditis virus (EMCV) 2B protein triggers translocation of mtDNA into the cytosol in a MAVS-dependent manner. Although influenza virus-induced cytosolic mtDN…
  • FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions. [Review]
    Int J Mol Sci 2019; 20(19)Kim M, Kwon Y, … Jeoung D
  • Anaphylaxis is an acute and life-threatening systemic reaction. Food, drug, aero-allergen and insect sting are known to induce anaphylaxis. Mast cells and basophils are known to mediate Immunoglobulin E (IgE)-dependent anaphylaxis, while macrophages, neutrophils and basophils mediate non IgE-dependent anaphylaxis. Histone deacetylases (HDACs) play various roles in biological processes by deacetyl…
  • Clinical aspects of hymenoptera venom allergy and venom immunotherapy. [Review]
    Eur Ann Allergy Clin Immunol 2019Bilò MB, Tontini C, … Antonicelli L
  • Hymenoptera venom allergy (HVA) is the most frequent cause of anaphylaxis in Europe, accounting for most of the severe reactions occurring in adults, and being the second cause of anaphylaxis in children. Prevention of further episodes in patients who developed a systemic reaction (SR) is based on the correct management of the allergic emergency, the referral to an allergist for a correct diagnos…
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