- Sleep problems in subacute myelo-optico neuropathy (SMON). [Journal Article]J Clin Neurosci. 2019 Oct; 68:128-133.JC
- Subacute myelo-optico neuropathy (SMON) patients typically suffer from sequelae that cause sleep disturbances. We sought to examine the prevalence of sleep problems among SMON patients. We conducted a questionnaire-based survey concerning sleep problems among 106 SMON patients, and 110 age- and gender-matched control participants. The prevalence of subjective insomnia (6 ≤ Athens Insomnia Scale s…
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- Physical Disabilities Related to the Depressive Mental States of Japanese Patients with Subacute Myelo-optico-neuropathy. [Journal Article]
- Objective The aim of this study was to clarify the clinical conditions related to the depressive mental states in Japanese patients with subacute myelo-optico-neuropathy (SMON), caused by clioquinol intoxication more than 40 years previously. Methods The changes in the mental states with aging were investigated in 25 Japanese SMON patients (mean age: 77.2 years old, range: 53-90) using a Japanese…
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- Tongue strength in patients with subacute myelo-optico-neuropathy. [Journal Article]J Clin Neurosci. 2018 Jan; 47:84-88.JC
- Subacute myelo-optico-neuropathy (SMON) is a neurodegenerative disease that may be caused by overdose or prolonged oral administration of clioquinol. Recently, dysphagia has attracted attention as a complication of SMON. To investigate lingual control in SMON, we examined patients with SMON using assessments of maximum tongue pressure, compared with dysphagia-related diseases, such as sporadic in…
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- The Aggravation of Depression with Aging in Japanese Patients with Subacute Myelo-optico-neuropathy (SMON). [Journal Article]
- Objective We attempted to clarify the factors related to the aggravation of depression in patients with subacute myelo-optico-neuropathy (SMON) caused by clioquinol intoxication more than 35 years previously. Methods We investigated changes in the depressive mental states that occurred with aging in 19 Japanese SMON patients (mean age, 78.3 years; range, 66-89 years) according to their scores on …
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- [SMON: toxicity of clioquinol and the status quo]. [Review]
- Subacute myelo-optico-neuropathy (SMON) is a disease characterized by subacute onset of sensory and motor disorders in the lower half of the body and visual impairment preceded by abdominal symptoms. A large number of SMON were observed throughout Japan, and the total number of cases reached nearly 10,000 by 1970. Despite clinical features mimicking infection or multiple sclerosis, SMON was confi…
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- Superoxide dismutase as a target of clioquinol-induced neurotoxicity. [Journal Article]
- Subacute myelo-optico-neuropathy (SMON) is a progressive neurological disorder affecting the spinal cord, peripheral nerves and optic nerves. Although it has been assumed that SMON was caused by intoxication of clioquinol, the mechanism underlying clioquinol-induced neurotoxicity is not fully understood. This study aimed to clarify the relevance of oxidative stress to clioquinol-induced neurotoxi…
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- [Spinal anesthesia in a patient with SMON disease]. [Case Reports]Masui. 2010 Sep; 59(9):1198-200.M
- We report a patient with subacute myelo-optico-neuropathy (SMON) in whom spinal anesthesia was employed to treat fracture of the femur neck. An 87-year-old woman was diagnosed as having SMON at the age of 45. The patient was admitted to our hospital with fracture of the femur neck. Aspiration pneumonia was also suspected with shadow in the right lung on the chest X-P The percutaneous oxygen satur…
- Change in activities of daily living, functional capacity, and life satisfaction in Japanese patients with subacute myelo-optico-neuropathy. [Journal Article]
- CONCLUSIONS: We observed decreases in ADL, functional capacity, and life satisfaction among SMON patients. Our results suggest that a decrease in life satisfaction can be prevented by maintaining or improving functional capacity.
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- Cervical MRI of subacute myelo-optico-neuropathy. [Case Reports]
- CONCLUSIONS: Although fainter, the abnormal T2 MRI signals we observed were similar to and occurred in the same locations as those reported in copper-deficient myelo-neuropathy patients. We suggest that these findings are useful to study the mechanism of clioquinol toxicity before using it to treat neurodegenerative diseases such as Alzheimer's disease.
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- Clinical studies on rising and re-rising neurological diseases in Japan--a personal contribution. [Review]
- Throughout my research life, I experienced to discover the causes of some neurological diseases in Japan. 1) SMON (subacute myelo-optico-neuropathy). Since the early 1960s, a peculiar neurological disease became prevalent throughout Japan. Through the chemical analysis of the green urine, characteristic of this disease, it was found that this disease was caused by intoxication of the administered…
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- [Development of neurology in Japan and its contribution to elucidate and resolve the sociomedical problems]. [Historical Article]Rinsho Shinkeigaku. 2009 Nov; 49(11):741-4.RS
- Japanese Society of Neurology (JSN) was established in 1960 with 643 members, and in 2009 it has grown up to a big society having more than 8,000 members including 3,600 neurology board specialists. JSN has greatly contributed in elucidating and resolving many socio-medical problems. I will take three topics including SMON (subacute myelo-optico-neuropathy), infectious Creutzfeldt-Jakob disease (…
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- Characteristics of disabilities in patients with subacute myelo-optico-neuropathy living at home: satisfaction in daily life and short form-36. [Journal Article]Disabil Rehabil. 2009; 31(23):1902-6.DR
- CONCLUSIONS: The subjective domains of the quality of life in patients with SMON were observed to have decreased. SDL was considered to closely reflect the characteristics of the disabilities observed in patients with SMON.
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- Activities of daily living, functional capacity, and life satisfaction of subacute myelo-optico-neuropathy patients in Japan. [Journal Article]
- CONCLUSIONS: The presence of neurological symptoms in SMON patients was associated with low functional capacity, life satisfaction, and ADL. Our results suggest that the life satisfaction of SMON patients can be increased by improving their functional capacity.
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- Depression in patients with subacute myelo-optico-neuropathy (SMON). [Journal Article]
- CONCLUSIONS: This is the first report that shows the prevalence of major depressive disorder in SMON patients at present, which was seven times more frequent than age-matched aged healthy persons.
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- Disability and lifestyle of subacute myelo-optico-neuropathy and stroke patients and elderly persons living at home: A comparison of the Barthel Index score and the Frenchay Activities Index score. [Journal Article]
- To evaluate subacute myelo-optico-neuropathy (SMON) and stroke patients and elderly persons by using the Barthel Index (BI) and Frenchay Activities Index (FAI) and to reveal the disability and lifestyle of SMON patients, cross sectional comparison study was performed. Forty SMON patients, 92 age-matched stroke patients with the same level of BI score and 92 age-matched elderly persons living at h…
- Diminished skin vasodilator response to local heating in patients with long-standingsubacute myelo-optico-neuropathy. [Journal Article]J Neurol Sci. 2007 Sep 15; 260(1-2):214-8.JN
- CONCLUSIONS: The SkBF response to local heating was diminished in SMON patients. This may reflect the involvement of the spinal cord, peripheral sensory nerves, and sympathetic post-ganglionic nerves in SMON.
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- Myelo-optico-neuropathy in copper deficiency occurring after partial gastrectomy. Do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance? [Case Reports]
- Acquired copper deficiency has recently been recognized as a cause of myeloneuropathy mimicking subacute combined degeneration due to vitamin B-12 deficiency. A remote history of gastric surgery is frequently associated with this syndrome. However, the very limited prevalence of severe copper deficiency in patients with a history of gastric surgery suggests that additional contributing factors ar…
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- [SMON--a model of the iatrogenic disease]. [Review]
- The subacute myelo-optico-neuropathy (SMON) was hazard caused by clioquinol, an antiseptic, prescribed for the treatment of diarrhea and other bowel symptoms. Its overdosing and long-term taking led to the occurrence of SMON, for which physicians should be responsible. Clioquinol, originally a disinfectant powder for external use, was diverted later to a drug for internal use to sterilize the bow…
- Clinical analysis of longstanding subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban. [Journal Article]
- One thousand and thirty-one longstanding patients with subacute myelo-optico-neuropathy (SMON; 275 males, 756 females; mean age +/- S.D., 72.9 +/- 9.6 years; age at onset 37.6 +/- 9.8 years; duration of illness 35.3 +/- 4.0 years) were examined in 2002, 32 years after banning of clioquinol. At onset, 66.7% of patients were unable to walk, and 4.7% complete blindness. At present time, about 41% of…
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- [Anesthetic management of two patients with the history of SMON]. [Journal Article]Masui. 2002 Aug; 51(8):907-9.M
- Patients of subacute myelo-optico-neuropathy (SMON) suffer from neurological disorders for a long time. The authors report anesthetic management of two patients with SMON. One patient was a 82-year-old woman suffering from SMON for 49 years. Sensory examination revealed numbness and hypesthesia in the both lower extremities. She underwent open reduction for femoral neck fracture. The other patien…
- [Neuropathology of longstanding subacute myelo-optico-neuropathy (SMON): an autopsy case of SMON with duration of 28 years]. [Case Reports]No To Shinkei. 2001 Sep; 53(9):875-80.NT
- The present case, 78-years-old female, had been troubled with SMON during 28 years, and was suddenly died from cerebral hemorrhage. The neuropathology characteristic for SMON could not be revealed in the spinal cord on routine histological preparations. There were decreasing number of immunopositive granules in the nucleus gracilis of medulla oblongata for synaptophysin, and in the marginal zone …
- Micturitional disturbance in subacute myelo-optico-neuropathy (SMON). [Journal Article]Auton Neurosci. 2001 Mar 23; 87(2-3):282-5.AN
- CONCLUSIONS: Our results indicate that supranuclear pelvic nerve dysfunction to be mainly responsible for the micturitional disturbance in patients with SMON.
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- Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals. [Review]
- It remains a tragic event that some 10,000 individuals in Japan developed a unique neurologic disease, subacute myelo-optico-neuropathy (SMON). Many of the affected patients still suffer serious sequelae, such as dysesthesia and muscle weakness in the lower extremities, and loss or deficits in visual acuity. Neuropathologic studies on SMON patients and experimental reproduction of the disease in …
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- [An anesthetic experience of a patient with subacute myelo-optico-neuropathy for bilateral mastectomy]. [Case Reports]Masui. 2000 Jun; 49(6):671-2.M
- A 79-year-old woman with subacute myelo-optico-neuropathy (SMON) underwent a bilateral mastectomy for breast cancer. She has been suffering from SMON for 32 years. Her preoperative neurological examination revealed cryesthesia and dyskinesia in the lower extremity, and numbness in the crues. Physical examination revealed respiratory dysfunction. A combination of general anesthesia and epidural bl…
- [Spinal anesthesia for a patient with long-term SMON]. [Case Reports]Masui. 1999 Jan; 48(1):79-80.M
- SMON (subacute myelo-optico-neuropathy) may result from clioquinol neurotoxicity. An 81-year-old woman underwent internal fixation for left intertrochanteric fracture. She had been diagnosed as having SMON twenty years previously. Sensory examination revealed paresthesia and decreased deep sensation in the lower extremity. A recent neuropathological report shows that in long-term SMON of about fi…
- CYP2D6 HhaI genotype and the neuroleptic malignant syndrome. [Clinical Trial]Neuropsychobiology. 1999; 39(1):33-7.N
- To investigate the relationship between CYP2D6 genotypes (reported to be associated with the susceptibilities to Parkinson's disease and multisystem atrophy) and the possible susceptibility to neuroleptic malignant syndrome (NMS) and subacute myelo-optico-neuropathy (SMON), we analyzed the CYP2D6 gene by polymerase chain reaction and restriction fragment length polymorphism in Japanese schizophre…
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- Isolation of Inoue-Melnick virus from cerebrospinal fluid of patients with epidemic neuropathy in Cuba. [Journal Article]
- CONCLUSIONS: Our study indicates an important association of IMV type 2 with patients of this Cuban epidemic. The etiologic role of IMV type 2 in the epidemic neuropathy in Cuba, along with weak cytopathic effect viruses isolated by the Cuban group, remains to be elucidated.
- Auditory and colored visual P300 in patients with sequelae of subacute myelo-optico-neuropathy. [Journal Article]Electroencephalogr Clin Neurophysiol. 1994 Oct; 91(4):265-74.EC
- To study the cognitive function in 13 patients with sequelae of subacute myelo-optico-neuropathy (SMON), event-related potentials (ERPs) were elicited with tones, clicks, and colored visual stimuli in different tasks. P300 latency was delayed, and P300 amplitude reduced or absent in 5 patients (38%), although neuropsychological assessment for dementia did not differ between patients and 21 age-ma…
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- [Age-related changes of B-cell immune function in patients with subacute myelo-optico-neuropathy (SMON)]. [Journal Article]Arerugi. 1994 Sep; 43(9):1215-9.A
- Several kinds of immunological abnormalities have been found more frequently in patients with subacute myelo-optico-neuropathy (SMON). To investigate whether the B-cell immune system is implicated in aging in patients with SMON, we examined serum levels of immunoglobulin including IgG, IgM, and IgA, and the number of CD20+ cells (B lymphocytes) and CD20+ CD23+ cells (activated B lymphocytes) usin…
- [Activated T cells in the peripheral blood of patients with subacute myelo-optico-neuropathy (SMON)]. [Journal Article]Arerugi. 1994 Mar; 43(3):515-20.A
- It has been reported that some kinds of immunological abnormalities are more frequently seen in patients with subacute myelo-optico-neuropathy (SMON), as compared with normal subjects. In order to examine whether ageing and clioquinol intoxication in the past may be implicated in the immunological disorders of the patients, we investigated soluble interleukin-2 receptors (sIL-2R) and an appearanc…