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  • Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. [Journal Article]
  • CTClin Toxicol (Phila) 2017; 55(5):346-351
  • Wong A, Sivilotti MLA, Graudins A
  • CONCLUSIONS: In modified-release paracetamol overdose treated with acetylcysteine, the paracetamol-aminotransferase multiplication product demonstrated similar accuracy and temporal profile to previous reports involving mostly immediate-release formulations. Above a cut-point of 10,000 mg/L × IU/L, it was very strongly associated with the development of acute liver injury and hepatotoxicity, especially when calculated more than eight hours post-ingestion. When below 1500 mg/L × IU/L the likelihood of developing hepatotoxicity was very low. Persistently high serial multiplication product calculations were associated with the greatest risk of hepatotoxicity.
  • Adolescent with prolonged toxidrome. [Case Reports]
  • CTClin Toxicol (Phila) 2017; 55(5):364-365
  • Johnson J, Williams K, Banner W
  • A 13-year-old female was presented to the emergency department following an intentional ingestion. The patient developed significant toxicity including multiple, discreet tonic-clonic seizures. Despi...
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