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(succimer)
2,395 results
  • All that glitters is not gold: Mercury poisoning in a family mimicking an infectious illness. [Journal Article]
    Curr Probl Pediatr Adolesc Health Care. 2020 Feb; 50(2):100758.Atti SK, Silver EM, … Geller RJ
  • Three siblings with inhalational elemental mercury toxicity presented with fever, rash, and upper respiratory tract symptoms. The patients were heavily exposed to elemental mercury that was spilled in their home and then vacuumed. Initial whole blood mercury levels were elevated at >200 µg/L, 153 µg/L and 130 µg/L (Mayo Clinic Laboratories lab reference range <9 µg/L) for Cases 1, 2, and 3, respe…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Succimer [BOOK]
    . National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Succimer is an oral heavy metal chelating agent used to treat lead and heavy metal poisoning. Succimer has been linked to a low rate of transient serum aminotransferase elevations during therapy, but its use has not been linked to cases of clinically apparent liver injury with jaundice.
  • DMSA-Functionalized Mesoporous Alumina with a High Capacity for Selective Isolation of Immunoglobulin G. [Journal Article]
    ACS Appl Mater Interfaces. 2019 Oct 02; 11(39):36286-36295.Wang XM, Guo PF, … Wang JH
  • A novel dimercaptosuccinic acid-functionalized mesoporous alumina (DMSA-MA) is synthesized by the dicarboxylic acid groups of dimercaptosuccinic acid molecules coordinating to the Al3+ ions located in the mesostructure. The as-prepared DMSA-MA composites possess a large surface area of 91.17 m2/g as well as a uniform pore size and a high pore volume of 17.22 nm and 0.23 cm3/g, respectively. DMSA …
  • Uptake of Intact Copper Oxide Nanoparticles Causes Acute Toxicity in Cultured Glial Cells. [Journal Article]
    Neurochem Res. 2019 Sep; 44(9):2156-2169.Joshi A, Thiel K, … Dringen R
  • Copper oxide nanoparticles (CuO-NPs) dispersions are known for their high cell toxic potential but contaminating copper ions in such dispersions are a major hurdle in the investigation of specific nanoparticle-mediated toxicity. In order to distinguish between the adverse effects exhibited by CuO-NPs and/or by contaminating ionic copper, the membrane-impermeable copper chelator bathocuproine disu…
  • Nephrotic syndrome caused by exposures to skin-lightening cosmetic products containing inorganic mercury. [Journal Article]
    Clin Toxicol (Phila). 2020 Jan; 58(1):9-15.Chan TYK, Chan APL, Tang HL
  • CONCLUSIONS: Repeated exposures to inorganic mercury in skin-lightening cosmetic products typically cause minimal change disease or membranous nephropathy, resulting in nephrotic syndrome. Apart from cessation of product use, chelation therapy is clearly indicated, in view of the etiological importance of mercury and the presence of increased body burden with target organ damage. The optimal dosages and treatment strategies for unithiol (2,3-dimercapto-1-propanesulfonic acid) and succimer (dimercaptosuccinic acid) have yet to be determined.
  • Crystal Transformation of β-CD-MOF Facilitates Loading of Dimercaptosuccinic Acid. [Journal Article]
    AAPS PharmSciTech. 2019 Jun 18; 20(6):224.Xiong Y, Wu L, … Zhang J
  • The β-cyclodextrin-metal-organic framework (β-CD-MOF), a potential drug delivery carrier, presents a densely packed laminated crystal structure (CCDC number 1041782) that prevents drug from entering inside the molecular voids in most CD units. In this paper, it was demonstrated that dimercaptosuccinic acid (DMSA), an instable small molecule chemical drug, was successfully loaded in β-CD-MOF with …
  • A Case of Accidental Mercury Intoxication. [Case Reports]
    J Emerg Med. 2019 Mar; 56(3):275-278.Kamensky OL, Horton D, … Bridges CC
  • Mercury poisoning is an uncommon diagnosis in the United States, but it is a differential diagnosis that physicians should consider because it can lead to potentially fatal complications if untreated. Due to the nonspecific presentation of mercury poisoning, which includes symptoms such as fever, nausea, vomiting, and abdominal pain, misdiagnosis may occur unless a proper history is taken.
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