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(succimer)
2,361 results
  • Nephrotic syndrome caused by exposures to skin-lightening cosmetic products containing inorganic mercury. [Journal Article]
    Clin Toxicol (Phila) 2019; :1-7Chan TYK, Chan APL, Tang HL
  • CONCLUSIONS: Repeated exposures to inorganic mercury in skin-lightening cosmetic products typically cause minimal change disease or membranous nephropathy, resulting in nephrotic syndrome. Apart from cessation of product use, chelation therapy is clearly indicated, in view of the etiological importance of mercury and the presence of increased body burden with target organ damage. The optimal dosages and treatment strategies for unithiol (2,3-dimercapto-1-propanesulfonic acid) and succimer (dimercaptosuccinic acid) have yet to be determined.
  • Crystal Transformation of β-CD-MOF Facilitates Loading of Dimercaptosuccinic Acid. [Journal Article]
    AAPS PharmSciTech 2019; 20(6):224Xiong Y, Wu L, … Zhang J
  • The β-cyclodextrin-metal-organic framework (β-CD-MOF), a potential drug delivery carrier, presents a densely packed laminated crystal structure (CCDC number 1041782) that prevents drug from entering inside the molecular voids in most CD units. In this paper, it was demonstrated that dimercaptosuccinic acid (DMSA), an instable small molecule chemical drug, was successfully loaded in β-CD-MOF with …
  • A Case of Accidental Mercury Intoxication. [Case Reports]
    J Emerg Med 2019; 56(3):275-278Kamensky OL, Horton D, … Bridges CC
  • Mercury poisoning is an uncommon diagnosis in the United States, but it is a differential diagnosis that physicians should consider because it can lead to potentially fatal complications if untreated. Due to the nonspecific presentation of mercury poisoning, which includes symptoms such as fever, nausea, vomiting, and abdominal pain, misdiagnosis may occur unless a proper history is taken.
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