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54,129 results
  • α-Ketoglutarate links p53 to cell fate during tumour suppression. [Journal Article]
    Nature 2019Morris JP, Yashinskie JJ, … Lowe SW
  • The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70% of pancreatic ductal adenocarcinoma (PDAC)1,2. Wild-type p53 accumulates in response to cellular stress, and regulates gene expression to alter cell fate and prevent tumour development2. Wild-type p53 is also known to modulate cellular metabolic pathways3, although p53-dependent metabolic alterations that cons…
  • SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2. [Journal Article]
    Nat Immunol 2019Burgener AV, Bantug GR, … Hess C
  • Whether screening the metabolic activity of immune cells facilitates discovery of molecular pathology remains unknown. Here we prospectively screened the extracellular acidification rate as a measure of glycolysis and the oxygen consumption rate as a measure of mitochondrial respiration in B cells from patients with primary antibody deficiency. The highest oxygen consumption rate values were dete…
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