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90 results
  • Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes. [Journal Article]
    Sci Rep 2019; 9(1):12347Elfawal MA, Savinov SN, Aroian RV
  • Soil-transmitted nematodes (STNs), namely hookworms, whipworms, and ascarids, are extremely common parasites, infecting 1-2 billion of the poorest people worldwide. Two benzimidazoles, albendazole and mebendazole, are currently used in STN mass drug administration, with many instances of low/reduced activity reported. New drugs against STNs are urgently needed. We tested various models for STN dr…
  • Stereospecific modulation of dimeric rhodopsin. [Journal Article]
    FASEB J 2019; 33(8):9526-9539Getter T, Gulati S, … Palczewski K
  • The classic concept that GPCRs function as monomers has been challenged by the emerging evidence of GPCR dimerization and oligomerization. Rhodopsin (Rh) is the only GPCR whose native oligomeric arrangement was revealed by atomic force microscopy demonstrating that Rh exists as a dimer. However, the role of Rh dimerization in retinal physiology is currently unknown. In this study, we identified e…
  • Identification of FDA-Approved Drugs with Activity against Stationary Phase Bartonella henselae. [Journal Article]
    Antibiotics (Basel) 2019; 8(2)Li T, Feng J, … Zhang Y
  • Bartonella henselae can cause various infections in humans, ranging from benign and self-limiting diseases to severe and life-threatening diseases as well as persistent infections that are difficult to treat. To develop more effective treatments for persistent Bartonella infections, in this study, we performed a high-throughput screen of an FDA-approved drug library against stationary phase B. he…
  • Diastereoselective α-Sulfenylation of N- tert-Butanesulfinyl Imidates. [Journal Article]
    J Org Chem 2018; 83(17):10580-10588Niu ST, Liu H, … Lu CD
  • A diastereoselective α-sulfenylation of chiral α-aryl/alkyl N- tert-butanesulfinyl imidates has been developed. Suitable sulfur electrophiles can be used as sulfenylating reagents to intercept aza-enolates generated from imidate deprotonation, giving α-thiofunctionalized imidates in good yields with high diastereocontrol. This protocol for C-S bond formation can efficiently synthesize enantioenri…
  • Drugs and Lactation Database (LactMed): Sulconazole [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • Topical sulconazole has not been studied during breastfeeding. About 11% of a dose is absorbed after topical application. It is considered a low risk to the nursing infant;[1] however, other antifungal agents with less absorption may be preferred, especially while nursing a newborn or preterm infant. Avoid application to the nipple area and ensure that the infant's skin does not come into direct …
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