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6,018 results
  • Interventions for maintenance of surgically induced remission in Crohn's disease: a network meta-analysis. [Review]
    Cochrane Database Syst Rev 2019; 9:CD013210Iheozor-Ejiofor Z, Gordon M, … Akobeng AK
  • CONCLUSIONS: Due to low-certainty evidence in the networks, we are unable to draw conclusions on which treatment is most effective for preventing clinical relapse and endoscopic relapse. Evidence on the safety of the interventions was inconclusive, however cases of pancreatitis and leukopenia from purine analogues were evident in the studies. Larger trials are needed to further understand the effect of the interventions on endoscopic relapse.
  • SLC19A1 transports immunoreactive cyclic dinucleotides. [Journal Article]
    Nature 2019; 573(7774):434-438Luteijn RD, Zaver SA, … Raulet DH
  • The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3. The binding of DNA to cGAS activates its enzymatic activity, leading to the synthesis of a second messenger, cyclic guanosi…
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