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1,273 results
  • Safety and tolerability of available urate-lowering drugs: a critical review. [Review]
    Expert Opin Drug Saf 2019; 18(4):261-271Strilchuk L, Fogacci F, Cicero AF
  • Urate-lowering therapy (ULT) is the cornerstone of gout management, which is a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus development, and urolithiasis. Since asymptomatic increased serum urate levels are associated with a higher risk of cardiovascular, renal and metabolic disorders, a larger use of ULTs in the general population is expected in the near future.
  • An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota. [Journal Article]
    Drug Metab Dispos 2018; 46(11):1596-1607van de Steeg E, Schuren FHJ, … Vaes WHJ
  • Colon microbiota-based drug metabolism has received little attention thus far in the process of drug development, whereas the role of gut microbiota in clinical safety and efficacy of drugs has become more clear. Many of these studies have been performed using animal studies, but the translational value of these data with respect to drug pharmacokinetics, efficacy, and safety is largely unknown. …
  • Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases. [Journal Article]
    Front Physiol 2018; 9:322Pan Y, Tian F, … Shang Q
  • Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous and exogenous compounds. In this study, two inhibitors of UGT enzymes, sulfinpy…
  • Effects of Discontinuation of Urate-Lowering Therapy: A Systematic Review. [Journal Article]
    J Gen Intern Med 2018; 33(3):358-366Beslon V, Moreau P, … Fournier JP
  • Urate-lowering therapy (ULT) is associated with low rates of adherence, leading to a potential risk of relapse of gouty arthritis, tophi, or urolithiasis. Our main aim was to identify the recurrence of gouty arthritis, tophi, or urolithiasis after discontinuation of ULT. Secondary aims included an assessment of ULT reintroduction rates and factors associated with relapse.
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