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266 results
  • Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology. [Review]
    J Ethnopharmacol 2019; 237:215-235Wei WL, Hou JJ, … Guo DA
  • CONCLUSIONS: Although VB possesses significant anti-tumor effect against various cancer cell lines, the development of new drugs still remains to be a challenge due to its pharmacodynamic effects in vivo, druggability and toxicology. The main problem lies in its side effects in vivo, poor bioavailability, fast metabolism, cardiotoxicity and neurovirulence. Besides, studies on its metabolism and toxicology in vitro and in vivo, as well as clinical trials should be further conducted for the new drug development and the establishment of optimal dosage of consumption of its administration.
  • Extraction, isolation and identification of flavonoid from Chenopodium album aerial parts. [Journal Article]
    J Tradit Complement Med 2018; 8(4):476-482Arora S, Itankar P
  • Chenopodium album L., (C. album) (family: Chenopodiaceae) is an annual shrub widely grown in Asia, Africa, Europe and North America. It is commonly known as Bathua (in Hindi), pigweed, fat hen or lamb-quarters. The leaves of C. album are applied as a poultice to bug bites, sunstroke, rheumatic joints and as mild laxative. The flavonoids contained in C. album aerial parts were extracted, identifie…
  • Medical diagnoses of heat wave-related hospital admissions in older adults. [Journal Article]
    Prev Med 2018; 110:81-85Hopp S, Dominici F, Bobb JF
  • Heat waves have been associated with adverse human health effects, including higher rates of all-cause and cardiovascular mortality, and these health effects may be exacerbated under continued climate change. However, specific causes of hospitalizations associated with heat waves have not been characterized on a national scale. We systematically estimated the risks of cause-specific hospitalizati…
  • Linear growth model analysis of factors affecting boar semen characteristics in Southern China. [Journal Article]
    J Anim Sci 2017; 95(12):5339-5346Wang C, Li JL, … Peng J
  • This study investigated the factors affecting the semen traits of boars in Southern China. A total of 172,408 ejaculates of boars from 9 AI centers were collected from January 2013 to May 2016. A linear growth model was used to analyze the effects of leve1 1 (boar breed, age, season, and boar age at herd entry) and level 2 (housing type) factors on semen quality. The intraclass correlation coeffi…
  • Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity. [Journal Article]
    J Ethnopharmacol 2016; 194:913-917Ye LH, Kong LT, … Chang Q
  • CONCLUSIONS: AF can strongly inhibit the activity of CYP2D6 enzyme, as confirmed by in vivo and in vitro models. Possible drug interactions may occur between AF and other medications metabolized by CYP2D6. Thus, caution should be paid when the lotus leaf and its preparations are concurrently administered with conventional medicines.
  • Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry. [Review]
    J Ethnopharmacol 2016; 193:670-690Dinda B, Kyriakopoulos AM, … Dinda M
  • CONCLUSIONS: Based on our review, Cornus mas L. (cornelian cherry) fruits and leaves can be used mainly in the treatment of diabetes, obesity, atherosclerosis, skin diseases, gastrointestinal and rheumatic problems. Some indications from ethnomedicines have been validated by pharmacological activities of the fruits and its extracts/pure isolates. The reported data reveal that the fruits are a potential source for treatment of diabetes, obesity, hyperlipidemia and gastrointestinal disorders. Unfortunately, the pharmacological studies in these areas are still insufficient to substantiate these preventive effects in confirmatory trials on the mass-scale clinical settings. Future studies on mechanisms of action, bioavailability, pharmacokinetics and adverse effects of the extracts and their bioactive constituents as well as their effective doses and long term toxic effects in humans are needed for commercial applications of these extracts/isolates in modern medicines. The available literature showed that most of the activities of the extracts are due to their constituents, anthocyanins, flavonoids and other phenolics, iridoids and vitamins for their antioxidant and other properties.
  • Expert consensus on standardized diagnosis and treatment for heat stroke. [Journal Article]
    Mil Med Res 2016; 3:1People’s Liberation Army Professional Committee of Critical Care Medicine
  • Heat stroke is a life-threatening disease characterized clinically by central nervous system dysfunction and severe hyperthermia (core temperature rises to higher than 40 °C). The unchecked rise of body core temperature overwhelms intrinsic or extrinsic heat generation mechanism, thus overwhelms homoeostatic thermoregulation. Hyperthermia causes cellular and organ dysfunction with progressive exa…
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