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185 results
  • Localised bullous pemphigoid overlying knee arthroplasty: a diagnostic challenge. [Case Reports]
    BMJ Case Rep 2019; 12(4)Truss A, Papalexandris S, … Harvey R
  • An elderly Caucasian woman developed bullous pemphigoid (BP) overlying the site of total knee arthroplasty for osteoarthritis 2 days after surgery. The clinical findings were consistent with blistering due to soft tissue swelling, bullous impetigo or allergic contact dermatitis. The blistering spread over weeks to months down the ipsilateral leg and then to the other leg and hips. A biopsy for H&…
  • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines. [Journal Article]
    PLoS One 2019; 14(1):e0209804Toro-Sazo M, Brea J, … Cassels BK
  • The last fifteen years have seen the emergence and overflow into the drug scene of "superpotent" N-benzylated phenethylamines belonging to the "NBOMe" series, accompanied by numerous research articles. Although N-benzyl substitution of 5-methoxytryptamine is known to increase its affinity and potency at 5-HT2 receptors associated with psychedelic activity, N-benzylated tryptamines have been studi…
  • Bullous pemphigoid, a dermatosis of the elderly [Journal Article]
    Rev Prat 2017; 67(10):1080-1083Hébert V, Joly P
  • Bullous pemphigoid, a dermatosis of the elderly. Bullous pemphigoid is the most common autoimmune bullous disease and affects almost exclusively the elderly. Its occurrence is related to the presence of pathogenic autoantibodies directed against structural proteins (BP180 and BP230) of the protein adhesion complex of the dermo-epidermal junction: the hemi-desmosome. Bullous pemphigoid is classica…
  • Update on the Systemic Risks of Superpotent Topical Steroids. [Case Reports]
    J Drugs Dermatol 2017; 16(7):643-648Nakamura M, Abrouk M, … Bhutani T
  • <p>INTRODUCTION: The potential for systemic effects due to percutaneous absorption of superpotent topical steroids has been a longstanding concern. The Food and Drug Administration currently recommends limiting the use of superpotent topical steroids to 50g per week for 2 or 4 consecutive weeks depending on the formulation, which is mostly based on the exact duration with which phase 3 clinical …
  • Use of Topical Corticosteroids in Dermatology: An Evidence-based Approach. [Review]
    Indian J Dermatol 2017 May-Jun; 62(3):237-250Das A, Panda S
  • Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullou…
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