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(sushi domain)
214 results
  • The complement system in schizophrenia: where are we now and what's next? [Review]
    Mol Psychiatry 2019Woo JJ, Pouget JG, … Kennedy JL
  • The complement system is a set of immune proteins involved in first-line defense against pathogens and removal of waste materials. Recent evidence has implicated the complement cascade in diseases involving the central nervous system, including schizophrenia. Here, we provide an up-to-date narrative review and critique of the literature on the relationship between schizophrenia and complement gen…
  • Endometriotic Peritoneal Fluid Promotes Myofibroblast Differentiation of Endometrial Mesenchymal Stem Cells. [Journal Article]
    Stem Cells Int 2019; 2019:6183796Zhang Z, Suo L, … Han X
  • During the development of endometriosis, the presence of fibrotic tissues in and surrounding endometriotic lesions may lead to subsequent adhesion, anatomic distortion, and chronic pain. Therefore, studies aimed at clarifying the underlying mechanisms of fibrogenesis in endometriosis could potentially provide a novel strategy for effective treatment. Mesenchymal stem cells (MSCs) play a key role …
  • Amyloid Precursor Protein (APP) and GABAergic Neurotransmission. [Journal Article]
    Cells 2019; 8(6)Tang BL
  • The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer's disease (AD), are generated by sequential proteolytic processing involving β- and γ-secretases. APP mutations underlie familial, early-onset AD, and the involvement of APP in AD pathology has been extensively studied. However, APP has important physiological r…
  • Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation. [Journal Article]
    eNeuro 2019 Mar/Apr; 6(2)Gutierrez MA, Dwyer BE, Franco SJ
  • Mutations and copy number variants of the CUB and Sushi multiple domains 2 (CSMD2) gene are associated with neuropsychiatric disease. CSMD2 encodes a single-pass transmembrane protein with a large extracellular domain comprising repeats of CUB and Sushi domains. High expression of CSMD2 in the developing and mature brain suggests possible roles in neuron development or function, but the cellular …
  • Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. [Journal Article]
    Nat Commun 2019; 10(1):1331Dinamarca MC, Raveh A, … Bettler B
  • GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs. Of the three interacting proteins, selectively the genetic loss of APP impaired GBR-mediated pr…
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