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(synophthalmia)
36 results
  • Synophthalmia in a Holstein cross calf. [Case Reports]
    Vet Res Forum 2014; 5(4):333-5Nourani H, Karimi I, Rajabi Vardanjani H
  • Synophthalmia is a form of cyclopia, in which some elements of two eyes are fused and form a single eye in the middle region of the forehead. The head of a Holstein female calf born from a 5-year-old cow was referred to Department of Pathology, School of Veterinary Medicine, Shahrekord University due to multiple congenital anomalies. The calf had been slaughtered immediately after birth due to se…
  • Differentiation of true anophthalmia from clinical anophthalmia using neuroradiological imaging. [Case Reports]
    World J Radiol 2014; 6(7):515-8Celebi AR, Sasani H
  • Anophthalmia is a condition of the absence of an eye and the presence of a small eye within the orbit. It is associated with many known syndromes. Clinical findings, as well as imaging modalities and genetic analysis, are important in making the diagnosis. Imaging modalities are crucial scanning methods. Cryptophthalmos, cyclopia, synophthalmia and congenital cystic eye should be considered in di…
  • Multiple complex congenital malformations in a rabbit kit (Oryctolagus cuniculi). [Case Reports]
    Comp Med 2013; 63(4):342-7Booth JL, Peng X, … Cooper TK
  • Congenital malformations may occur during early embryogenesis in cases of genetic abnormalities or various environmental factors. Affected subjects most often have only one or 2 abnormalities; subjects rarely have several unrelated congenital defects. Here we describe a case of a stillborn New Zealand white rabbit with multiple complex congenital malformations, including synophthalmia, holoprosen…
  • A screen of zebrafish mutants identifies ethanol-sensitive genetic loci. [Journal Article]
    Alcohol Clin Exp Res 2014; 38(3):694-703Swartz ME, Wells MB, … Eberhart JK
  • CONCLUSIONS: Our results provide insight into the gene-EtOH interactions that may underlie EtOH teratogenesis. They support previous findings that EtOH disrupts elongation of the embryonic axis. Importantly, these results show that the zebrafish is an efficient model with which to test for gene-EtOH interactions. Understanding these interactions will be crucial to understanding of the FASD variation.
  • Ethanol alters gene expression and cell organization during optic vesicle evagination. [Journal Article]
    Neuroscience 2013; 250:493-506Santos-Ledo A, Cavodeassi F, … Arévalo R
  • Ethanol has been described as a teratogen in vertebrate development. During early stages of brain formation, ethanol affects the evagination of the optic vesicles, resulting in synophthalmia or cyclopia, phenotypes where the optic vesicles partially or totally fuse. The mechanisms by which ethanol affects the morphogenesis of the optic vesicles are however largely unknown. In this study we make u…
  • A unique case of unilateral synophthalmia. [Case Reports]
    Pediatr Dev Pathol 2011 Mar-Apr; 14(2):130-3Proia AD
  • Developmental anomalies resulting in a single eye (cyclopia) or fusion of the eyes (synophthalmia) are rare. Examples of unilateral synophthalmia-in which there are 1 normal and 2 fused eyes from 3 anlagen in 2 orbits, 1 lateral proboscis, and 3 optic nerves-are even more rare. Herein, I report a unique fetus with unilateral synophthalmia that was not associated with a lateral proboscis but inste…
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