- Hypogastric Artery Occlusion with Evoked Potentials Monitoring as Bailout Technique to Assess the Risk of Postoperative Spinal Cord Ischemia. [Journal Article]
- AAorta (Stamford) 2019; 7(1):22-26
- A 65-year-old man, with previous open surgical repair of an infrarenal abdominal aortic, presented with acute complicated (paraplegia) Type B aortic dissection. He successfully underwent endovascular…
A 65-year-old man, with previous open surgical repair of an infrarenal abdominal aortic, presented with acute complicated (paraplegia) Type B aortic dissection. He successfully underwent endovascular repair of the descending thoracic and abdominal aorta. Following the procedure, the neurological manifestations resolved. As he had a concomitant aneurysm of the right hypogastric artery (HGA), we executed a 10-minute balloon occlusion of this artery with evoked potential measurements to assess the risk of spinal cord ischemia after exclusion of the right HGA. The examination was interpreted as negative, and we proceeded with coil embolization of the right HGA and subsequent placement of an endograft landing distally within the external iliac artery. The postoperative course was totally uneventful, and the patient was discharged home 4 days after the operation. Computed tomography angiography follow-up at 1, 6, 12 and 24 months showed patency of all endografts without any signs of endoleak and effective remodeling of the descending thoracic aorta with volume reduction of the false lumen.
- Nitrogen mustard gas molecules and α-arsenene nanosheet interaction studies - A DFT insight. [Journal Article]
- JMJ Mol Graph Model 2019 Jul 14; 92:65-73
- Bis(2-chloroethyl)ethylamine (HN-1) and Bis(2-chloroethyl)methylamine (HN-2) are two classifications under the blistering agents, which are taken as target nitrogen mustard gas in the current researc…
Bis(2-chloroethyl)ethylamine (HN-1) and Bis(2-chloroethyl)methylamine (HN-2) are two classifications under the blistering agents, which are taken as target nitrogen mustard gas in the current research. α-arsenene nanosheets in its puckered configuration, are employed as a prime material to detect the above mentioned gas molecules. The chemo-sensing nature of the base material towards the target gas is ascertained with the assistance of electronic and surface assimilating attributes with the help of density functional theory technique. Initially, the geometric firmness of the base material is ensured with formation energy, which was computed to be -4.262 eV/atom, and we studied the electronic properties like the density of states spectrum, band structure, and electron density. Furthermore, surface assimilating attributes like Bader charge transfer, adsorption energy, average energy gap variation are estimated at atomistic levels using ATK-VNL package. The adsorption of nitrogen mustard gas molecules on α-arsenene nanosheets shows physisorption type of binding. The average energy gap variation of α-arsenene nanosheets upon adsorption of nitrogen mustard gas molecules ranges from 1.33 to 4.1%. Hence, the results suggest that α-arsenene nanosheets can be used as a chemical nanosensor for nitrogen mustard gas.
- Safety of Laparoscopic Gastrostomy in Children Receiving Peritoneal Dialysis. [Journal Article]
- JSJ Surg Res 2019 Jul 19; 244:460-467
- CONCLUSIONS: We found that, in children already receiving PD, LG is similar in safety profile, efficacy, and technical principle to open gastrostomy. LG is therefore an appropriate and safe alternative to open gastrostomy in this setting.
- Drug sellers' neutralizations of guiltless drug sales and avoidance of "drug dealer" identities. [Journal Article]
- IJInt J Drug Policy 2019 Jul 19; 73:16-23
- CONCLUSIONS: We conclude by suggesting that neutralizations vary by offender characteristics due to the differing background expectancies of offenders' social groups. We also suggest that neutralizing the repercussions of immoral actions is not always a static, monothematic technique. It is instead an active, complex, and interactional process that occurs as persons make sense of who they are and what they are doing. Finally, we argue that studies of neutralization theory relying on direct, standardized questions or the presentation of abstract vignettes may fail to capture a sizable part of the neutralization process among offenders.
- Treatment of olive processing wastewater by electrocoagulation: An effectiveness and economic assessment. [Journal Article]
- JEJ Environ Manage 2019 Jul 19; 248:109262
- In the present study, the technique of electrocoagulation (EC) followed by filtration was explored at the laboratory scale for the removal of organic compounds from olive debittering wastewater (ODW)…
In the present study, the technique of electrocoagulation (EC) followed by filtration was explored at the laboratory scale for the removal of organic compounds from olive debittering wastewater (ODW). Different parameters such as electrode type and distance as well as sample pH, current density, and electrolysis time were investigated in batch experiments with identical electrode geometries. Our results showed that highest pollutant removal efficiency and lowest operational cost were achieved using two Al electrodes at a distance of 1 cm apart with a sample pH of 4.0. Moreover, rises in the electrolysis time and current density (up to 60 min and 15 mA cm-2, respectively) led to improvements in the removal of chemical oxygen demand (COD), total polyphenolic compounds (TPC), and turbidity. Under optimized conditions, the removal of COD, TPC and turbidity reached 78.51, 90.44 and 97.92%, respectively; the values of 1.01 g m-3, 12.0 kWh cm-3 and 0.12 USD m-3 were calculated as the electrode consumption, electrical energy consumption and operating cost, respectively. Chromatography results revealed tyrosol and catechin as the main phenolic compounds present in both the initial effluent and the generated sludge.
- Purification and biochemical characterisation of a putative sodium channel agonist secreted from the South African Knobbly sea anemone Bunodosoma capense. [Journal Article]
- TToxicon 2019 Jul 19
- Voltage gated ion channels have become a subject of investigation as possible pharmaceutical targets. Research has linked the activity of ion channels directly to anti-inflammatory pathways, energy h…
Voltage gated ion channels have become a subject of investigation as possible pharmaceutical targets. Research has linked the activity of ion channels directly to anti-inflammatory pathways, energy homeostasis, cancer proliferation and painful diabetic neuropathy. Sea anemones secrete a diverse array of bioactive compounds including potassium and sodium channel toxins. A putative novel sodium channel agonist (molecular mass of 4619.7 Da) with a predicted sequence: CLCNSDGPSV RGNTLSGILW LAGCPSGWHN CKKHKPTIGW CCK was isolated from Bunodosoma capense using a modified stimulation technique to induce the secretion of the neurotoxin rich mucus confirmed by an Artemia nauplii bio-assay. The peptide purification combined size-exclusion and reverse-phase high performance liquid chromatography. A thallium-based ion flux assay confirmed the presence of a sodium channel agonist/inhibitor and purity was determined using a modified tricine SDS-PAGE system. The peptide isolated indicated the presence of multiple disulfide bonds in a tight β-defensin cystine conformation. An IC50 value of 26 nM was determined for total channel inhibition on MCF-7 cells. The unique putative sodium channel agonist initiating with a cystine bond indicates a divergent evolution to those previously isolated from Bunodosoma species.
- Anatomic Pathology Data Generation in Preclinical Toxicology Evaluation: Troubleshooting and Risk Management for Toxicologists. [Journal Article]
- TLToxicol Lett 2019 Jul 19
- In routine regulatory toxicology studies, the anatomic pathology endpoints are frequently the most significant element of the study data. They may profoundly influence subsequent clinical development…
In routine regulatory toxicology studies, the anatomic pathology endpoints are frequently the most significant element of the study data. They may profoundly influence subsequent clinical development and use of a test article, with implications for both human safety and for the fate of key commercial assets. Unfortunately (in common with other perceptual medical specialties), anatomic pathology data are also among the most subjective endpoints in regulatory toxicology studies - a challenge magnified by the fact that not only the diagnostic data but the anatomic pathologist's interpretation of it in their narrative report represent raw data within a regulated study (United States Federal Register, 1987). A strategy for minimizing and managing the risk of misdiagnosis/misinterpretation of pathology data is critical for any preclinical toxicology development program and is a collaborative approach between study directors, study monitors and toxicologists and toxicologic pathologists. The article provides a basic understanding of the sources of error and limitations of anatomic pathology evaluation, a starting point for troubleshooting and a basis for a sound management strategy. It describes common reasons for unexpected or inconsistent pathology findings and sets out to provide a framework for toxicologists to approach commissioning and critically evaluating their pathology data, and for identifying situations where additional third-party advice and review may be justified.
- Trust and distrust in relation to food risks in Spain: An approach to the socio-cultural representations of pregnant and breastfeeding women through the technique of free listing. [Journal Article]
- AAppetite 2019 Jul 19; :104365
- In this paper, we explore the socio-cultural representations of trust and distrust in relation to food risks among pregnant and breastfeeding women. We have conducted a study based on an analysis of …
In this paper, we explore the socio-cultural representations of trust and distrust in relation to food risks among pregnant and breastfeeding women. We have conducted a study based on an analysis of cultural domains in order to understand how mothers incorporate different social meanings and explore the most important categories they use when talking about trust/distrust in relation to food. We use the technique of free listings to analyse the main shared items or elements regarding trust and distrust in food among these mothers. Through an analysis of cultural domains that refers to concepts and themes related to trust and distrust of foods that are important to these women, and through the study of shared knowledge about these domains, we examine their socio-cultural representations related to health and diet of the 65 free listings on trust and the 64 on distrust collected from mothers. The pregnant and breastfeeding women who participated in the free listings cite foods they trust or distrust based on the specific properties they perceive them to have or other characteristics related to their origin, their handling, processing and distribution. Additionally, trust/distrust often depends on the qualities they attribute to the product. This paper shows aspects of the socio-cultural representations of food risks in periods in the life cycle of women -pregnancy and breastfeeding-characterized by a risk discourse where the precautionary principle is frequently used to manage uncertainty. These results might help the development of public health campaigns as well as adapting the messages of the health authorities to the general population.
- Automatic detection of the epileptogenic zone: an application of the Fingerprint of Epilepsy. [Journal Article]
- JNJ Neurosci Methods 2019 Jul 19; :108347
- CONCLUSIONS: Our method is highly accurate, automated and non-parametric providing clinicians another tool that can be used to help identify the epileptogenic zone in patients undergoing the stereo electroencephalography procedure for epilepsy monitoring.
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- Observation of Continuous Contraction and a Metastable Misfolded State during the Collapse and Folding of a Small Protein. [Journal Article]
- JMJ Mol Biol 2019 Jul 19
- To obtain proper insight into how structure develops during a protein folding reaction, it is necessary to understand the nature and mechanism of the polypeptide chain collapse reaction which marks t…
To obtain proper insight into how structure develops during a protein folding reaction, it is necessary to understand the nature and mechanism of the polypeptide chain collapse reaction which marks the initiation of folding. Here, the time-resolved fluorescence resonance energy transfer technique, in which the decay of the fluorescence light intensity with time, is used to determine the time evolution of the distribution of intra-molecular distances, has been utilized to study the folding of the small protein, monellin. It is seen that when folding begins, about one-third of the protein molecules collapse into a molten globule state (IMG), from which they relax by continuous further contraction to transit to the native state. The larger fraction gets trapped into a metastable misfolded state. Exit from this metastable state occurs via collapse to the lower free energy IMG state. This exit is slow, on a time scale of seconds, because of activation energy barriers. The trapped misfolded molecules as well as the IMG molecules contract continuously and slowly as structure develops. A phenomenological model of Markovian evolution of the polymer chain undergoing folding, incorporating these features, has been developed, that fits well the experimentally observed time evolution of distance distributions. The observation that the "wrong turn" to the misfolded state has not been eliminated by evolution belies the common belief that the folding of functional protein sequences is very different from that of a random heteropolymer, and the former have been selected by evolution to fold quickly.