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3,100 results
  • Early Nuclear Events after Herpesviral Infection. [Review]
    J Clin Med 2019; 8(9)Full F, Ensser A
  • Herpesviruses are important pathogens that can cause significant morbidity and mortality in the human population. Herpesviruses have a double-stranded DNA genome, and viral genome replication takes place inside the nucleus. Upon entering the nucleus, herpesviruses have to overcome the obstacle of cellular proteins in order to enable viral gene expression and genome replication. In this review, we…
  • Antiviral activity of the sea cucumber tegument extract (Pattalus mollis) on human rotavirus A (RVA). [Journal Article]
    Nat Prod Res 2019; :1-5Garcia-Candela E, Pariona-Velarde C, … Chumpitaz-Cerrate V
  • The antiviral effect against RVA in cell culture was evaluated by using an aqueous extract of Patallus mollis sea cucumber, applying the titration methodology. This technique is used to measures the ability of the extract dilutions to inhibit the cytopathic effect (CPE) of the virus, expressed as percentage of inhibition (IP). The mean extract cytotoxic concentration (CC50) used in the antiviral …
  • DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV. [Journal Article]
    Cell 2019; 178(6):1329-1343.e12Gong D, Dai X, … Zhou ZH
  • Assembly of Kaposi's sarcoma-associated herpesvirus (KSHV) begins at a bacteriophage-like portal complex that nucleates formation of an icosahedral capsid with capsid-associated tegument complexes (CATCs) and facilitates translocation of an ∼150-kb dsDNA genome, followed by acquisition of a pleomorphic tegument and envelope. Because of deviation from icosahedral symmetry, KSHV portal and tegument…
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